Results 61 to 70 of about 10,435,031 (361)

Functional labeling of individualized postsynaptic neurons using optogenetics and trans-Tango in Drosophila (FLIPSOT).

PLoS Genetics
A population of neurons interconnected by synapses constitutes a neural circuit, which performs specific functions upon activation. It is essential to identify both anatomical and functional entities of neural circuits to comprehend the components and ...
Allison N Castaneda, Ainul Huda, Iona B M Whitaker, Julianne E Reilly, Grace S Shelby, Hua Bai, Lina Ni   +6 more
doaj   +1 more source

Neuromodulated Spike-Timing-Dependent Plasticity and Theory of Three-Factor Learning Rules

Frontiers in Neural Circuits, 2016
Classical Hebbian learning puts the emphasis on joint pre- and postsynaptic activity, but neglects the potential role of neuromodulators. Since neuromodulators convey information about novelty or reward, the influence of neuromodulatorson synaptic ...
Wulfram eGerstner, Nicolas eFremaux
doaj   +1 more source

Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4. [PDF]

, 2014
Lrp4, the muscle receptor for neuronal Agrin, is expressed in the hippocampus and areas involved in cognition. The function of Lrp4 in the brain, however, is unknown, as Lrp4-/- mice fail to form neuromuscular synapses and die at birth.
Burden, Steven J, Froemke, Robert C, Gomez, Andrea M   +2 more
core   +1 more source

Postsynaptic Target Specificity of Neurotrophin-Induced Presynaptic Potentiation [PDF]

Neuron, 2000
The role of the target cell in neurotrophin-induced modifications of glutamatergic synaptic transmission was examined in cultured hippocampal neurons. Brain-derived neurotrophic factor (BDNF) induced rapid and persistent potentiation of evoked glutamate release when the postsynaptic neuron was glutamatergic, or excitatory (E-->E), but not when it was ...
Benedikt Berninger, Mu-ming Poo, Alejandro F. Schinder   +2 more
openaire   +3 more sources

An Ultra‐Robust Memristor Based on Vertically Aligned Nanocomposite with Highly Defective Vertical Channels for Neuromorphic Computing

Advanced Functional Materials, EarlyView.
An ultra‐robust memristor based on SrTiO3‐CeO2 (S‐C) vertically aligned nanocomposite (VAN) achieving exceptional endurance of 1012 switching cycles via interface engineering. Artificial neural networks (ANNs) integrated with S‐C VAN memristors exhibit high training accuracy across multiple datasets.
Zedong Hu, Hongyi Dou, Jeremy B. Gan, Cun Li, Xuanyu Sheng, Juanjuan Lu, Abhijeet Choudhury, Jialong Huang, Yizhi Zhang, Zhongxia Shang, Ye Cao, Xinghang Zhang, Haiyan Wang   +12 more
wiley   +1 more source

Loss of FKBP5 Affects Neuron Synaptic Plasticity: An Electrophysiology Insight [PDF]

, 2019
FKBP5 (FKBP51) is a glucocorticoid receptor (GR) binding protein, which acts as a co-chaperone of heat shock protein 90 (HSP90) and negatively regulates GR.
Deng, Ran, Dou, Longyu, Liang, Tiebing, Liu, Ming, Qiu, Bin, Ren, Wei, Shou, Weinian, Stewart, Robert B., Wang, Chao, Wang, Jun, Williams, Kent E., Xie, Zhongwen, Xu, Yuxue, Yong, Weidong, Zhao, Zhenwen   +14 more
core   +1 more source

Potentiation of Developing Synapses by Postsynaptic Release of Neurotrophin-4 [PDF]

Neuron, 1997
The hypothesis that synaptic functions can be regulated by neurotrophins secreted from the postsynaptic cell was examined in Xenopus nerve-muscle cultures. Neuromuscular synapses formed on myocytes overexpressing neurotrophin-4 (M+ synapses) exhibited a higher level of spontaneous synaptic activity and enhanced evoked synaptic transmission as compared ...
Xin-hao Wang, Mu-ming Poo
openaire   +3 more sources

Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics

Advanced Materials, EarlyView.
Harnessing photo‐energy conversion in nanomaterials enables precision theranostics through light‐driven mechanisms such as photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered surface‐enhanced Raman scattering (SERS), and photodynamic processes. This review explores six fundamental principles of photo‐energy conversion, recent
Jingyu Shi, Yadi Fan, Qin Zhang, Yingying Huang, Mo Yang   +4 more
wiley   +1 more source

Role of Amorphous Phases in Mixed Conduction of Conjugated Regioblock Copolymers for Organic Electrochemical Synaptic Transistors

Advanced Materials, EarlyView.
Critical roles of amorphous and crystalline phases in polymer‐based mixed ionic‐electronic conductors for organic electrochemical synaptic transistors using conjugated regioregular‐block‐regiorandom copolymers are demonstrated. Amorphous phases contribute to gradual polaron formation and strong ion trapping by bipolarons, leading to improved synaptic ...
Kwang‐Hun Choi, Seongil Im, Aaron Plant, Carlos Neri Soto, Hanna Lee, Changsoon Choi, Ho Won Jang, Jeong Ho Cho, Hyunsu Ju, Youngmin Lee, Jung Ah Lim   +10 more
wiley   +1 more source

Support vector machines for spike pattern classification with a leaky integrate-and-fire neuron

Frontiers in Computational Neuroscience, 2012
Spike pattern classification is a key topic in machine learning, computational neuroscience and electronic device design. Here we offer a new approach for supervised spike pattern classification, combining a bio-mimetic neuron model with a method based ...
Maxime eAmbard, Stefan eRotter
doaj   +1 more source