Results 81 to 90 of about 10,517,225 (330)

Zwitterionic Fluoropolymer‐Engineered Synaptic Clefts Enhance Ion Dynamics in Neuromorphic OECTs

Advanced Materials Technologies, EarlyView.
Polyzwitterionic DPVDF (DPVDF‐SZ) ion gels enhance neuromorphic OECT performance due to their reduced crystallinity compared to conventional fluoropolymer (e.g., PVDF‐HFP). These ion gels enable high transconductance, stable ion diffusion, and synaptic plasticity, including long‐term memory. Reservoir computing validation highlights their potential for
Ji Seon Kim, Young Je Kwon, Jung‐Hye Song, Yoon Ah Im, Dong Jun Han, Ho Jin Jung, Kie Yong Cho, Eun Kwang Lee   +7 more
wiley   +1 more source

Light Intensity‐Controlled Photoconductance Polarity Switching for Neuromorphic and Logic Applications

Advanced Optical Materials, EarlyView.
Light intensity‐induced photoconductance polarity switching is demonstrated in geometrically asymmetric Schottky MoSe2 devices. The devices exhibit bidirectional reconfigurable optoelectronic logic gates and synaptic applications using a single light source, opening new avenues for multifunctional optoelectronic and neuromorphic computing systems ...
Amin Abnavi, Hamidreza Ghanbari, Mohammad Reza Mohammadzadeh, Ribwar Ahmadi, Michael M. Adachi   +4 more
wiley   +1 more source

Parasubthalamic Glutamatergic Neurons Coordinate Cardiovascular Homeostasis and Locomotion in Mice

Advanced Science, EarlyView.
PSTNVglut2 neurons function as a new central baroreflex hub via projections to the NTS, modulating parasympathetic cardiac output to maintain cardiovascular homeostasis while synchronously regulating locomotion. Blood pressure fluctuations negatively correlate with locomotor performance.
Ming‐Xuan Lu, Jin‐Yin Huang, Xing‐Zhe Xu, Ji‐Yu Sun, Dan‐Ni Zou, Jia‐Yao Zhang, Chen Chi, Qi Zhang, Wei‐Cai Liu   +8 more
wiley   +1 more source

A Ca2+-based computational model for NDMA receptor-dependent synaptic plasticity at individual post-synaptic spines in the hippocampus

Frontiers in Synaptic Neuroscience, 2010
Associative synaptic plasticity is synapse specific and requires coincident activity in presynaptic and postsynaptic neurons to activate NMDA receptors (NMDARs). The resultant Ca2+ influx is the critical trigger for the induction of synaptic plasticity.
Owen Rackham, Krasimira Tsaneva-Atanasova, Ayalvadi Ganesh, Jack Mellor   +3 more
doaj   +1 more source

Differential expression of an inwardly rectifying chloride conductance in rat brain neurons: a potential mechanism for cell-specific modulation of postsynaptic inhibition

Journal of Neuroscience, 1995
A voltage-sensitive inwardly rectifying chloride (Cl-) conductance (GCl(V) is present in hippocampal pyramidal but not dentate gyrus neurons and has a significant role in modulation of neuronal inhibition by GABA.
RL Smith, GH Clayton, Clayton Wilcox, KW Escudero, K. Staley   +4 more
semanticscholar   +1 more source

Human iPSC‐Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease

Advanced Science, EarlyView.
Short‐term intravenous treatments with iPSC‐derived mononuclear phagocytes (iMPs) improve cognitive decline and neural health in two mouse models of aging and in the 5xFAD mouse model of Alzheimer's disease. iMPs reduce levels of serum amyloid proteins that increase in aging and improve the health of hippocampal microglia and mossy cells.
V. Alexandra Moser, Luz Jovita Dimas‐Harms, Rachel M. Lipman, Jake Inzalaco, Shaughn Bell, Michelle Alcantara, Erikha Valenzuela, George Lawless, Simion Kreimer, Sarah J. Parker, Helen S. Goodridge, Clive N. Svendsen   +11 more
wiley   +1 more source

Pigment Epithelium‐Derived Factor Deficiency Impairs Hippocampal Glutamate Homeostasis and Cognitive Function by Downregulating Astrocytic GLT‐1

Advanced Science, EarlyView.
The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi, Qi‐Long Tang, Jin‐Hong Wang, Yan‐Lan Long, Sai‐Feng Zhao, Zhen Zhao, Wan‐Ting Xie, Zi‐Ming Li, Hao‐Ming Lu, Tian‐Xiao Gao, Zhen‐Zhen Fang, Ti Zhou, Bo‐Xing Li, Xia Yang, Guo‐Quan Gao, Wei‐Wei Qi   +15 more
wiley   +1 more source

A Peripheral Mechanism of Depression: Disturbed Intestinal Epithelial Per2 Gene Expression Causes Depressive Behaviors in Mice with Circadian Rhythm Disruption via Gut Barrier Damage and Microbiota Dysbiosis

Advanced Science, EarlyView.
Circardian rhythm disorder (CRD) causes abnormal expression of intestinal Period 2 (Per2) gene, which compromising intestinal barrier integrity and altering the gut microenvironment. Microbiota dysbiosis and aberrant metabolites production drive central inflammation, impair neurogenesis, and promote functional deficits, ultimately facilitating the ...
Huiliang Zhang, Xuan Qin, Haiyue Song, Jieru Zhou, Hui Wei, Lun Zhang, Yi Liu, Zhuoqun Wang, Yiren Zhang, Yiwen Lai, Jiayu Yang, Wenting Hu, Zhongshan Chen, Ji Zeng, Yu Jin, Xiaochuan Wang, Rong Liu   +16 more
wiley   +1 more source

Effects of Ketamine on Neuronal Spontaneous Excitatory Postsynaptic Currents and Miniature Excitatory Postsynaptic Currents in the Somatosensory Cortex of Rats

Iranian Journal of Medical Sciences, 2016
Background: Ketamine is a commonly used intravenous anesthetic which produces dissociation anesthesia, analgesia, and amnesia. The mechanism of ketamine-induced synaptic inhibition in high-level cortical areas is still unknown.
Chengdong Yuan, Yajun Zhang, Yu Zhang, Song Cao, Yuan Wang, Bao Fu, Tian Yu   +6 more
doaj  

Synaptic cell-adhesion molecule latrophilin-2 is differentially directed to dendritic domains of hippocampal neurons

iScience
Summary: Hippocampal pyramidal cells possess elaborate dendritic arbors with distinct domains that are targeted with input-specific synaptic sites. This synaptic arrangement is facilitated by synaptic cell-adhesion molecules that act as recognition ...
Thomas R. Murphy, Ryan F. Amidon, Jordan D. Donohue, Libo Li, Garret R. Anderson   +4 more
doaj   +1 more source