Results 91 to 100 of about 3,016,110 (399)

Potassium channel KIR4.1 as an immune target in multiple sclerosis.

New England Journal of Medicine, 2012
BACKGROUND Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system. Many findings suggest that the disease has an autoimmune pathogenesis; the target of the immune response is not yet known.
R. Srivastava, Muhammad Aslam, S. Kalluri, Lucas Schirmer, D. Buck, B. Tackenberg, Veit Rothhammer, A. Chan, R. Gold, A. Berthele, J. Bennett, T. Korn, B. Hemmer   +12 more
semanticscholar   +1 more source

Renal potassium channels: An overview [PDF]

Kidney International, 1995
The introduction of the patch-clamp technique by Neher and Sackmann [1, 2] has led to the successful exploration of potassium (K) channels in the kidney, allowing the definition of their properties, localization along the nephron and their regulation [3–6].
openaire   +2 more sources

Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno‐Cancer Therapy

Advanced Functional Materials, EarlyView.
MXenzyme‐mediated bioelectricity cancer therapy (MXenzyme‐BECT) enhances cancer cell death through irreversible depolarization, ion channel disruption, ROS generation, and immunogenic cell death. Computational simulations reveal the electrical mechanisms by which MXenzyme acts on single cells and support to predict treatment parameters. Next‐generation
Sanghee Lee, Seongchan Kim, Eui‐Sang Yu, Sian Lee, Min Jun Ko, Hyojin Lee, Dong‐Hyun Kim   +6 more
wiley   +1 more source

Gating and selectivity mechanisms for the lysosomal K+ channel TMEM175

eLife, 2020
Transmembrane protein 175 (TMEM175) is a K+-selective ion channel expressed in lysosomal membranes, where it establishes a membrane potential essential for lysosomal function and its dysregulation is associated with the development of Parkinson’s Disease.
SeCheol Oh, Navid Paknejad, Richard K Hite   +2 more
doaj   +1 more source

A novel potassium channel in photosynthetic cyanobacteria. [PDF]

PLoS ONE, 2010
Elucidation of the structure-function relationship of a small number of prokaryotic ion channels characterized so far greatly contributed to our knowledge on basic mechanisms of ion conduction.
Manuela Zanetti, Enrico Teardo, Nicoletta La Rocca, Lalu Zulkifli, Vanessa Checchetto, Toshiaki Shijuku, Yuki Sato, Giorgio Mario Giacometti, Noboyuki Uozumi, Elisabetta Bergantino, Ildikò Szabò   +10 more
doaj   +1 more source

What have we learned from two-pore potassium channels? Their molecular configuration and function in the human heart [PDF]

, 2012
Two-pore domain potassium channels (K2P) control excitability, stabilize the resting membrane potential below firing threshold, and accelerate repolarisation in different cells.
Benyhe, Sándor, Boyett, Marc, Dobrzynski, Halina, Dézsi, László, Erdélyi, Lajos, Papp, Gyula, Szalontai, Balázs, Szüts, Viktória, Varró, András, Vágvölgyi, Csaba, Zhang, Henggui, Ötvös, Ferenc   +11 more
core  

Searching for self-similarity in switching time and turbulent cascades in ion transport through a biochannel. A time delay asymmetry

, 2003
The process of ion transport through a locust potassium channel is described by means of the Fokker-Planck equation (FPE). The deterministic and stochastic components of the process of switching between various conducting states of the channel are ...
Ausloos, Bassingthwaighte, Benzi, Bezrukov, Cha, Colquhoun, Colquhoun, de Oliveira, Fredkin, Friedrich, Frisch, Fuliński, Gardiner, Ghashghaie, Gorczyńska, Hille, Ivanova, Jiang, Kristinka Ivanova, Liebovitch, Marcel Ausloos, Mercik, Mercik, Neher, Renner, Risken, Roncaglia, Schrempf, Siwy, Siwy, Siwy, Varotsos, Wagner, Zuzanna Siwy   +33 more
core   +1 more source

Photothermal Hydrogel with Mn3O4 Nanoparticles Alleviates Intervertebral Disc Degeneration by Scavenging ROS and Regulating Extracellular Matrix Metabolism

Advanced Functional Materials, EarlyView.
The MPTT‐nanozyme‐hydrogel system (Mn3O4@ChS‐HA) provides a multifunctional therapeutic strategy for intervertebral disc degeneration (IVDD), effectively targeting oxidative stress and enhancing AF repair by restoring extracellular matrix (ECM) and redox homeostasis.
Yangyang Chen, Chan Xue, Feifei Ni, Binwu Hu, Miaoheng Yan, He Zhang, Yuxiang Hu, Xiaoyao Peng, Guangfang Li, Yu Han, Hongjian Liu, Zengwu Shao, Qin Wang, Yulong Wei   +13 more
wiley   +1 more source

Distinct Distribution Patterns of Potassium Channel Sub-Units in Somato-Dendritic Compartments of Neurons of the Medial Superior Olive

Frontiers in Cellular Neuroscience, 2019
Coincidence detector neurons of the medial superior olive (MSO) are sensitive to interaural time differences in the range of a few tens of microseconds. The biophysical basis for this remarkable acuity is a short integration time constant of the membrane,
Alisha L. Nabel, Alisha L. Nabel, Alexander R. Callan, Alexander R. Callan, Sarah A. Gleiss, Sarah A. Gleiss, Nikolaos Kladisios, Christian Leibold, Felix Felmy, Felix Felmy   +9 more
doaj   +1 more source

High‐Entropy Magnetism of Murunskite

Advanced Functional Materials, EarlyView.
The study of murunskite (K2FeCu3S4) reveals that its magnetic and orbital order emerges in a simple I4/mmm crystal structure with complete disorder in the transition metal positions. Mixed‐valence Fe ions randomly occupy 1/4 of the tetrahedral sites, with the remaining 3/4 being filled by non‐magnetic Cu+ ions.
Davor Tolj, Priyanka Reddy, Ivica Živković, Luka Akšamović, Jian Rui Soh, Kamila Komȩdera, Izabela Biało, Naveen Kumar Chogondahalli Muniraju, Trpimir Ivšić, Mario Novak, Oksana Zaharko, Clemens Ritter, Thomas LaGrange, Wojciech Tabiś, Ivo Batistić, László Forró, Henrik M. Rønnow, Denis K. Sunko, Neven Barišić   +18 more
wiley   +1 more source