Results 101 to 110 of about 3,016,110 (399)

Activation of KATP channels in pain modulation: a systematic review of preclinical studies

Frontiers in Physiology
ObjectiveTo systematically review the involvement of KATP channel activation in pain modulation in preclinical studies.BackgroundKATP channels are expressed at several levels in the spinal and trigeminal pain pathways, where they seem to modulate ...
Signe Schønning Beich, Lili Kokoti, Mohammad Al-Mahdi Al-Karagholi, Mohammad Al-Mahdi Al-Karagholi   +3 more
doaj   +1 more source

KCNJ11: Genetic Polymorphisms and Risk of Diabetes Mellitus

Journal of Diabetes Research, 2015
Diabetes mellitus (DM) is a major worldwide health problem and its prevalence has been rapidly increasing in the last century. It is caused by defects in insulin secretion or insulin action or both, leading to hyperglycemia.
Polin Haghvirdizadeh, Zahurin Mohamed, Nor Azizan Abdullah, Pantea Haghvirdizadeh, Monir Sadat Haerian, Batoul Sadat Haerian   +5 more
doaj   +1 more source

Voltage-Gated Potassium Channel Kv1.3 as a Target in Therapy of Cancer

Frontiers in Oncology, 2019
Voltage-gated potassium channel Kv1.3 is an integral membrane protein, which is selectively permeable for potassium ions and is activated upon a change of membrane potential.
Andrzej Teisseyre, Anna Palko-Labuz, Kamila Sroda-Pomianek, Krystyna Michalak   +3 more
doaj   +1 more source

A Lipid Bilayer Formed on a Hydrogel Bead for Single Ion Channel Recordings

Micromachines, 2020
Ion channel proteins play important roles in various cell functions, making them attractive drug targets. Artificial lipid bilayer recording is a technique used to measure the ion transport activities of channel proteins with high sensitivity and ...
Minako Hirano, Daiki Yamamoto, Mami Asakura, Tohru Hayakawa, Shintaro Mise, Akinobu Matsumoto, Toru Ide   +6 more
doaj   +1 more source

K-ATP channel gene expression is induced by urocortin and mediates its cardioprotective effect [PDF]

, 2002
Background-Urocortin is a novel cardioprotective agent that can protect cardiac myocytes from the damaging effects of ischemia/reperfusion both in culture and in the intact heart and is effective when given at reperfusion.Methods and Results-We have ...
Chanalaris, A, Comini, L, Ferrari, R, Hubank, M, Knight, RA, Latchman, DS, Lawrence, KM, Pasini, E, Scarabelli, T, Stephanou, A, Tinker, A, Townsend, PA   +11 more
core  

Regulation of Proliferation by a Mitochondrial Potassium Channel in Pancreatic Ductal Adenocarcinoma Cells [PDF]

, 2017
Previous results link the mitochondrial potassium channel Kv1.3 (mitoKv1.3) to the regulation of apoptosis. By synthesizing new, mitochondria-targeted derivatives (PAPTP and PCARBTP) of PAP-1, a specific membrane-permeant Kv1.3 inhibitor, we have ...
Amigorena, Arcangeli, Beeton, Cahalan, Checchetto, Chittajallu, Cholo, Cidad, Comes, Connor, Deutsch, Diebold, Diwakarla, Doyle, Erdogan, Esteras, Fraser, Ghiani, Heginbotham, Hinz, Hu, Jang, Koren, Leanza, Leanza, Leanza, Lin, Long, Lu, Malinska, Manago, Nilius, Pardo, Peruzzo, Ralph, Ralph, Rauer, Shieh, Siegel, Szabo, Szabo, Tegla, Tonks, Urrego, Van Rensburg, Xu, Zaccagnino, Zhou, Zucca   +48 more
core   +2 more sources

Potassium Channels and Neurovascular Coupling

Circulation Journal, 2010
Neuronal activity is communicated to the cerebral vasculature so that adequate perfusion of brain tissue is maintained at all levels of neuronal metabolism. An increase in neuronal activity is accompanied by vasodilation and an increase in local cerebral blood flow.
Dunn, Kathryn M., Nelson, Mark T.
openaire   +4 more sources

Iridium Oxide Inverse Opal Anodes with Tailored Porosity for Efficient PEM Electrolysis

Advanced Functional Materials, EarlyView.
The synthesis of Iridium‐based Inverse Opals (Ir‐IO) is reported as electrocatalyst for Proton exchange membrane water electrolysis (PEM‐WE). Using the developed protocol it produces highly porous materials consisting either of metallic, oxidic Iridium or a combination thereof with large surface areas.
Sebastian Möhle, Matthias Kroschel, Peter Strasser   +2 more
wiley   +1 more source

ADMET evaluation in drug discovery. 12. Development of binary classification models for prediction of hERG potassium channel blockage.

Molecular Pharmaceutics, 2012
Inhibition of the human ether-a-go-go related gene (hERG) potassium channel may result in QT interval prolongation, which causes severe cardiac side effects and is a major problem in clinical studies of drug candidates. The development of in silico tools
Sichao Wang, Youyong Li, Junmei Wang, Lei Chen, Liling Zhang, Huidong Yu, Tingjun Hou   +6 more
semanticscholar   +1 more source

Tuning the Hydrogen Bond Network Inside the Helmholtz Plane for Industrial Hydrogen Evolution

Advanced Functional Materials, EarlyView.
The hydrogen bond network within the Helmholtz plane, a key component affecting the hydrogen evolution kinetics, remains far from having a consensus owing to the lack of fundamental understanding. Herein, it is discovered that the introduction of the atomic electric field generated by the weak Ru─Ga bonds can further improve the proportion of 4 ...
Xinyu Chen, Bianjing Sun, Qun Song, Zengbin Wang, Chenchen Qin, Muhammad Amjad Majeed, Chuntao Chen, Dongping Sun, Kai Zhang, Ming Zhao   +9 more
wiley   +1 more source