Results 11 to 20 of about 3,016,110 (399)
Inactivation in the potassium channel KcsA
Journal of Structural Biology: X, 2019 Inactivation, the slow cessation of transmission after activation, is a general feature of potassium channels. It is essential for their function, and malfunctions in inactivation leads to numerous pathologies.
Yunyao Xu, Ann E. McDermott
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Structure of potassium channels [PDF]
Cellular and Molecular Life Sciences, 2015 Potassium channels ubiquitously exist in nearly all kingdoms of life and perform diverse but important functions. Since the first atomic structure of a prokaryotic potassium channel (KcsA, a channel from Streptomyces lividans) was determined, tremendous progress has been made in understanding the mechanism of potassium channels and channels conducting ...
Pasi Purhonen +4 more
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Drunk potassium channels [PDF]
Europace, 2011 We report the case of a 42-year-old woman who was admitted due to alcohol induced dehydration leading to cardiac symptoms. On physical examination severe hypokalaemia and long QT syndrome were apparent. During potassium (K+) supplementation we simultaneously observed QT interval recovery.
Amir M. Nia +3 more
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Potassium Channels in Epilepsy [PDF]
Cold Spring Harbor Perspectives in Medicine, 2016 This review attempts to give a concise and up-to-date overview on the role of potassium channels in epilepsies. Their role can be defined from a genetic perspective, focusing on variants and de novo mutations identified in genetic studies or animal models with targeted, specific mutations in genes coding for a member of the large potassium channel ...
Jakob Wolfart, Rüdiger Köhling
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The effect of potential-dependent potassium uptake on membrane potential in rat brain mitochondria [PDF]
The Ukrainian Biochemical Journal, 2013 The effect of potential-dependent potassium uptake on the transmembrane potential difference (ΔΨm) in rat brain mitochondria has been studied. It was shown that in potassium concentration range of 0-120 mM the potential-dependent K+-uptake into matrix ...
O. V. Akopova +5 more
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Molecules, 2022 Scorpion venom is a rich source of promising therapeutic compounds, such as highly selective ion channel ligands with potent pharmacological effects. Bot33 is a new short polypeptide of 38 amino acid residues with six cysteines purified from the venom of
Rym ElFessi +6 more
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Mitochondrial Potassium Channels as Druggable Targets
Biomolecules, 2020 Mitochondrial potassium channels have been described as important factors in cell pro-life and death phenomena. The activation of mitochondrial potassium channels, such as ATP-regulated or calcium-activated large conductance potassium channels, may have ...
Antoni Wrzosek +3 more
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Toxins, 2015 The potassium channels were recently found to be inhibited by animal toxin-like human β-defensin 2 (hBD2), the first defensin blocker of potassium channels. Whether there are other defensin blockers from different organisms remains an open question. Here,
Fang Xiang +7 more
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FEBS Letters, 2003 The atomic structures of K+ channels have added a new dimension to our understanding of K+ channel function. I will briefly review how structures have influenced our views on ion conduction, gating of the pore, and voltage sensing.
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Effects of cromakalim (BRL 34915) on potassium conductances in CA3 neurons of the guinea-pig hippocampus in vitro [PDF]
, 1989 The action of the potassium channel activator, cromakalim (BRL 34915), on membrane potential, input resistance and current-voltage-relationship of CA3 neurons in a slice preparation of the guinea-pig hippocampus was investigated by means of intracellular
Alzheimer, Christian +2 more
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