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Potassium channels and epilepsy
Acta Neurologica Scandinavica, 2022With the development and application of next‐generation sequencing technology, the aetiological diagnosis of genetic epilepsy is rapidly becoming easier and less expensive. Additionally, there is a growing body of research into precision therapy based on
Kai Gao +3 more
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Cell Calcium, 2022
Lysosomes are acidic membrane-bound organelles that use hydrolytic enzymes to break down material through pathways such as endocytosis, phagocytosis, mitophagy, and autophagy. To function properly, intralysosomal environments are strictly controlled by a set of integral membrane proteins such as ion channels and transporters.
Peng, Huang +4 more
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Lysosomes are acidic membrane-bound organelles that use hydrolytic enzymes to break down material through pathways such as endocytosis, phagocytosis, mitophagy, and autophagy. To function properly, intralysosomal environments are strictly controlled by a set of integral membrane proteins such as ion channels and transporters.
Peng, Huang +4 more
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IEEE Transactions on Nanobioscience, 2005
Potassium channels are integral membrane proteins that selectively transport K+ across the cell membrane. They are present in all mammalian cells and have a wide variety of roles in both excitable and nonexcitable cells. The phenotypic diversity required to accomplish their various roles is created by differences in conductance, the timecourse and ...
Stephen J, Korn, Josef G, Trapani
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Potassium channels are integral membrane proteins that selectively transport K+ across the cell membrane. They are present in all mammalian cells and have a wide variety of roles in both excitable and nonexcitable cells. The phenotypic diversity required to accomplish their various roles is created by differences in conductance, the timecourse and ...
Stephen J, Korn, Josef G, Trapani
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Mitochondrial potassium channels
IUBMB Life, 2009AbstractMitochondrial potassium channels are believed to contribute to cytoprotection of injured cardiac and neuronal tissues. The following potassium channels have been described in the inner mitochondrial membrane: the ATP‐regulated potassium channel, the large conductance Ca2+‐activated potassium channel, the voltage‐gated Kv1.3 potassium channel ...
Adam, Szewczyk +2 more
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Presynaptic potassium channels
Current Opinion in Neurobiology, 1996The past year has witnessed some significant improvements in our understanding of the molecular diversity, subunit composition, and functional properties of K+ channels in heterologous expression systems. Immunocytochemical studies have yielded important information on the localization of K+ channel proteins to synaptic terminals in mammalian brain ...
J, Roeper, O, Pongs
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INWARD RECTIFIER POTASSIUM CHANNELS
Annual Review of Physiology, 1997▪ Abstract The past three years have seen remarkable progress in research on the molecular basis of inward rectification, with significant implications for basic understanding and pharmacological manipulation of cellular excitability. Expression cloning of the first inward rectifier K channel (Kir) genes provided the necessary breakthrough that has ...
C G, Nichols, A N, Lopatin
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Annual Review of Physiology, 2002
▪ Abstract Potassium channels are multi-subunit complexes, often composed of several polytopic membrane proteins and cytosolic proteins. The formation of these oligomeric structures, including both biogenesis and trafficking, is the subject of this review.
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▪ Abstract Potassium channels are multi-subunit complexes, often composed of several polytopic membrane proteins and cytosolic proteins. The formation of these oligomeric structures, including both biogenesis and trafficking, is the subject of this review.
openaire +2 more sources