Results 21 to 30 of about 441,914 (371)

Genomic organization and chromosomal localization of the murine 2 P domain potassium channel gene Kcnk8: conservation of gene structure in 2 P domain potassium channels. [PDF]

open access: yes, 2000
A 2 P domain potassium channel expressed in eye, lung, and stomach, Kcnk8, has recently been identified. To initiate further biochemical and genetic studies of this channel, we assembled the murine Kcnk8 cDNA sequence, characterized the genomic structure
Bockenhauer, D   +4 more
core   +1 more source

Diverse Structural Features of Potassium Channels Characterized by Scorpion Toxins as Molecular Probes

open access: yesMolecules, 2019
Scorpion toxins are well-known as the largest potassium channel peptide blocker family. They have been successfully proven to be valuable molecular probes for structural research on diverse potassium channels. The potassium channel pore region, including
Yonghui Zhao   +4 more
doaj   +1 more source

Effects of cromakalim (BRL 34915) on potassium conductances in CA3 neurons of the guinea-pig hippocampus in vitro [PDF]

open access: yes, 1989
The action of the potassium channel activator, cromakalim (BRL 34915), on membrane potential, input resistance and current-voltage-relationship of CA3 neurons in a slice preparation of the guinea-pig hippocampus was investigated by means of intracellular
Alzheimer, Christian   +2 more
core   +1 more source

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. [PDF]

open access: yes, 1999
A novel potassium channel gene has been cloned, characterized, and associated with cardiac arrhythmia. The gene encodes MinK-related peptide 1 (MiRP1), a small integral membrane subunit that assembles with HERG, a pore-forming protein, to alter its ...
Antzelevitch   +64 more
core   +1 more source

Potassium Channel Mechanics [PDF]

open access: yesNeuron, 2001
What is the moving part that switches an ion channel's current on and off? In this issue of Neuron del Camino and Yellen (2001) exploit scanning cysteine mutagenesis and sulfhydryl reagents to show that the intracellular end of the S6 helices forms a mechanical gate for the Shaker potassium channel.
openaire   +3 more sources

hERG potassium channel blockage by scorpion toxin BmKKx2 enhances erythroid differentiation of human leukemia cells K562. [PDF]

open access: yesPLoS ONE, 2013
The hERG potassium channel can modulate the proliferation of the chronic myelogenous leukemic K562 cells, and its role in the erythroid differentiation of K562 cells still remains unclear.The hERG potassium channel blockage by a new 36-residue scorpion ...
Jian Ma   +5 more
doaj   +1 more source

Human sperm ion channel (dys)function:implications for fertilization [PDF]

open access: yes, 2019
BACKGROUND: Intensive research on sperm ion channels has identified members of several ion channel families in both mouse and human sperm. Gene knock-out studies have unequivocally demonstrated the importance of the calcium and potassium conductances in ...
Barratt, Christopher L. R.   +3 more
core   +3 more sources

POTASSIUM CHANNELS AS DRUGS TARGETS IN THERAPY OF CARDIOVASCULAR DESEASES: 25 YEARS LATER [PDF]

open access: yesSanamed, 2013
Potassium channels are the most variable ion channel group. They participate in numerous cardiovascular functions, for example regulation of vascular tone, maintenance of resting cardiac membrane potential and excitability of cardiac conduction tissue ...
Protić Dragana   +2 more
doaj   +2 more sources

The conduction pathway of potassium channels is water free under physiological conditions. [PDF]

open access: yes, 2019
Ion conduction through potassium channels is a fundamental process of life. On the basis of crystallographic data, it was originally proposed that potassium ions and water molecules are transported through the selectivity filter in an alternating ...
Chevelkov, V.   +9 more
core   +1 more source

Potassium channels: Novel targets for tumor diagnosis and chemoresistance

open access: yesFrontiers in Oncology, 2023
In recent years, the role of potassium channels in tumors has been intensively studied. Potassium channel proteins are widely involved in various physiological and pathological processes of cells.
Meizeng Li   +4 more
doaj   +1 more source

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