Results 91 to 100 of about 65,085 (300)

Voltage-Gated K+/Na+ Channels and Scorpion Venom Toxins in Cancer

Frontiers in Pharmacology, 2020
Ion channels have recently been recognized as novel therapeutic targets in cancer research since they are overexpressed in different histological tissues, and their activity is linked to proliferation, tumor progression, angiogenesis, metastasis, and ...
Alexis Díaz-García, Alexis Díaz-García, Diego Varela, Diego Varela   +3 more
doaj   +1 more source

Achieving High‐Density and Stress‐Resilient Maize Breeding Via Germplasm Innovation

Advanced Science, EarlyView.
Global population growth and climate change have exacerbated the global food crisis. This perspective presents a conceptual framework focusing on enhancing population advantages. Several novel breeding objectives are proposed to improve density tolerance and stress resistance for yield improvement.
Xinlong Li, Yongqiang Chen, Dong Ding, Xuehai Zhang, Xuxiang Jia, Zhanhui Zhang, Yafei Wang, Weihua Li, Hui Zhang, Jihua Tang   +9 more
wiley   +1 more source

Jingzhaotoxin-X, a gating modifier of Kv4.2 and Kv4.3 potassium channels purified from the venom of the Chinese tarantula Chilobrachys jingzhao

Journal of Venomous Animals and Toxins including Tropical Diseases
Background: The tarantula Chilobrachys jingzhao is one of the largest venomous spiders in China. In previous studies, we purified and characterized at least eight peptides from C. jingzhao venom.
Meichun Deng, Liping Jiang, Xuan Luo, Huai Tao, Songping Liang   +4 more
doaj   +1 more source

Ciguatoxins: Cyclic Polyether Modulators of Voltage-gated Iion Channel Function

Marine Drugs, 2006
Ciguatoxins are cyclic polyether toxins, derived from marine dinoflagellates, which are responsible for the symptoms of ciguatera poisoning. Ingestion of tropical and subtropical fin fish contaminated by ciguatoxins results in an illness characterised by
Richard J. Lewis, Graham M. Nicholson
doaj   +1 more source

Sustainable Synaptic Device with Two‐Dimensional Ferroelectric Materials for Neuromorphic Computing

Advanced Science, EarlyView.
α‐In2Se3 based FeSFETs can be utilized as sustainable devices through polarization switching governed by both out‐of‐plane and in‐plane polarizations. Upon reaching a fatigued state, current annealing enabled by conductance modulation can significantly enhance the endurance of FeSFETs.
Jaewook Yoo, Seokjin Oh, Minah Park, Jong Min Song, Hongseung Lee, Seohyeon Park, Sojin Jung, Seongbin Lim, Soohyun Lim, Dongsun Shin, Ji Won Heo, TaeWan Kim, Hagyoul Bae   +12 more
wiley   +1 more source

Proestrus Differentially Regulates Expression of Ion Channel and Calcium Homeostasis Genes in GnRH Neurons of Mice

Frontiers in Molecular Neuroscience, 2019
In proestrus, the changing gonadal hormone milieu alters the physiological properties of GnRH neurons and contributes to the development of the GnRH surge.
Csaba Vastagh, Norbert Solymosi, Imre Farkas, Zsolt Liposits, Zsolt Liposits   +4 more
doaj   +1 more source

voltage-gated potassium channel.png

, 2016
The protein family includes 5 members: MinK, MiRP (MinK-related peptides) 1, MiRP2, MiRP3 and MiRP4, encoded by KCNE 1-5 respectively. These proteins are small type I integral membrane proteins, which can associate with and regulate various voltage-gated
Thomas Hooper (2927814)
core   +1 more source

Self-organized enhancement of conductivity in biological ion channels [PDF]

, 2013
We discuss an example of self-organization in a biological system. It arises from long-range ion–ion interactions, and it leads us to propose a new kind of enhanced conduction in ion channels.
Kaufman, Igor, Khovanov, I. A., Khovanov, Igor A., McClintock, P. V. E., Eisenberg, Robert S., Luchinsky, Dmittri G., McClintock, Peter V. E., Eisenberg, R. S., Luchinsky, Dmitrii G., Tindjong, Rodrigue   +9 more
core   +1 more source

Synchronization‐Dissipation in the Cardiorespiratory System

Advanced Science, EarlyView.
By modeling central nervous coupling and viscoelastic interactions in the cardiorespiratory system we show that synchronization produces a 10% gain in cardiac efficiency in humans. It is surmised that respiratory sinus arrhythmia improves cardiac pumping efficiency by reducing dynamic stress and power dissipation in the pulmonary vasculature.
Joshua R. Border, Alain Nogaret, Andrew Lefevre, Vishal Jain   +3 more
wiley   +1 more source

A Correlative SICM‐OPM Platform for Surface and Volumetric Imaging in Live Cells

Advanced Science, EarlyView.
A multifunctional correlative imaging platform integrating Scanning Ion Conductance Microscopy (SICM) with Oblique Plane Microscopy (OPM) enables simultaneous surface topography, mechanical mapping, and 3D volumetric fluorescence imaging in live cells.
Wenzhi Hong, Ziwei Zhang, Ao Li, Ting Sun, Yunzhao Wu, Devkee M. Vadukul, Dylan Jones, Bing Li, Fengjie Liu, Francesco A. Aprile, Yuri Korchev, Julia Gorelik, David Klenerman, Andrew Shevchuk   +13 more
wiley   +1 more source