Results 81 to 90 of about 1,936,204 (283)

Investigations on subunit-specific assembly and structure-function studies of the voltage sensor in KCNQ potassium channels [PDF]

, 2007
A detailed understanding of how potassium channels function is crucial e. g. for the development of drugs, which could lead to novel therapeutic concepts for diseases ranging from diabetes to cardiac abnormalities.
Athanasiadu, Despina, Athanasiadu, D.
core  

CNTN2 Deficiency Disrupts Ascending Auditory Neuroglial Interactions and Redox Homeostasis in Neural Presbycusis

Advanced Science, EarlyView.
. ABSTRACT Neural presbycusis disrupts auditory timing and speech perception, yet its molecular basis remains poorly understood. This study identifies Cntn2 as the Ranvier's nodal molecule significantly downregulated in aged auditory nerves. Cntn2 heterozygous knockout (Cntn2+/−) mice showed elevated auditory brainstem response thresholds and prolonged
Penghui Chen, Jingyi Zhu, Sihan Huang, Beibei Xu, Maoli Duan, Jingrong Lv, Jiarui Chen, Jun Yang, Shule Hou   +8 more
wiley   +1 more source

Potential roles of voltage-gated ion channel disruption in Tuberous Sclerosis Complex

Frontiers in Molecular Neuroscience
Tuberous Sclerosis Complex (TSC) is a lynchpin disorder, as it results in overactive mammalian target of rapamycin (mTOR) signaling, which has been implicated in a multitude of disease states.
Hailey X. Egido-Betancourt, Roy E. Strowd III, Kimberly F. Raab-Graham   +2 more
doaj   +1 more source

Voltage‐gated potassium channels: from hyperexcitability to excitement [PDF]

FEBS Letters, 1999
The superfamily of voltage‐activated potassium channels may express structurally and functionally diverse voltage‐activated potassium channels in the nervous system. The roles of some voltage‐activated potassium channel types, e.g. rapidly inactivating (transiently active type) channels and muscarine sensitive muscarine sensitive channels, are ...
openaire   +2 more sources

International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels

, 2003
This summary article presents an overview of the molecular relationships among the voltage-gated potassium channels and a standard nomenclature for them, which is derived from the IUPHAR Compendium of Voltage-Gated Ion Channels.
McKinnon, D., Wei, A, Rudy, B, Vandenberg, C A, Florian Lesage, Kurachi, Y., Jonathan Robbins, Lesage, Florian, Andreas Karschin, Karschin, A., Wulff, Heike, Robertson, G., Ganetzky, B, Desir, G V, Stuehmer, W, Covarriubias, Manuel, O'Kelly, Ita, Chandy, K., Garcia, M L, Adelman, John P., K. George Chandy, Bayliss, Douglas A., Vandenberg, C., Clapham, D E, Mckinnon, D, Ganetzky, Barry, Nichols, C., Kurachi, Yoshihisa, Carol A. Vandenberg, Yoshihisa Kurachi, O'Kelly, I, Stühmer, W., Gail A. Robertson, Lester, H., Walter Stuehmer, John P. Adelman, Barry Ganetzky, Lazdunski, M, Wymore, R., Covarriubias, M., Garcia, M., Wei, A., O'Kelly, I., Sanguinetti, Michael, Tamkun, M., Aiyar, J, Grissmer, Stephan, Sabina Kuperschmidt, Michael Sanguinetti, Sanguinetti, M., Karschin, Andreas, Karschin, A, Nichols, C G, Chandy, K. George, Vandenberg, Carol A., Michel Lazdunski, S. Wymore, Rudy, B., Seino, S, Randy, Sanguinetti, M, Stuehmer, Walter, Donghee Kim, Robertson, Gail A., Jan, L., Jan, L Y, Adelman, J P, Robbins, J., Lester, Henry A., Furuichi, K., Colin G. Nichols, Wymore, R S, Tamkun, M M, Gutman, G A, Garcia, Maria L., Wei, Aguan, Clapham, D., Lester, H A, Kuperschmidt, S, Tamkun, Michael M., Michael M. Tamkun, Aiyar, Jayashree, Desir, Gary V., Lesage, F, Kurachi, Y, Aguan Wei, Robbins, Jonathan, Jayashree Aiyar, David Mckinnon, Desir, G., Bayliss, D A, Furuichi, Kiyoshi, Kim, D, Stephan Grissmer, Rudy, Bernardo, Kim, D., Kiyoshi Furuichi, Seino, S., Robbins, J, Lazdunski, Michel, Bayliss, D., Wulff, H., Gutman, George A., Wymore, Randy S., Kuperschmidt, Sabina, Jan, Lily Y., Henry A. Lester, Ganetzky, B., Douglas A. Bayliss, Nichols, Colin G., George A. Gutman, Lily Y. Jan, Chandy, K G, Covarriubias, M, Aiyar, J., Gary V. Desir, Maria L. Garcia, Manuel Covarriubias, Lazdunski, M., Seino, Susumu, Bernardo Rudy, Grissmer, S, Furuichi, K, McKinnon, David, Wulff, H, Gutman, G., Kuperschmidt, S., Lesage, F., Kim, Donghee, Grissmer, S., Heike Wulff, Adelman, J., Clapham, David E., David E. Clapham, Susumu Seino, Robertson, G A   +135 more
core   +1 more source

A universal model for spike-frequency adaptation [PDF]

, 2003
Spike-frequency adaptation is a prominent feature of neural dynamics. Among other mechanisms, various ionic currents modulating spike generation cause this type of neural adaptation.
Andreas V. M. Herz, Benda, Jan, Jan Benda, Herz, Andreas V. M.   +3 more
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Jingzhaotoxin-X, a gating modifier of Kv4.2 and Kv4.3 potassium channels purified from the venom of the Chinese tarantula Chilobrachys jingzhao

Journal of Venomous Animals and Toxins including Tropical Diseases
Background: The tarantula Chilobrachys jingzhao is one of the largest venomous spiders in China. In previous studies, we purified and characterized at least eight peptides from C. jingzhao venom.
Meichun Deng, Liping Jiang, Xuan Luo, Huai Tao, Songping Liang   +4 more
doaj   +1 more source

Ciguatoxins: Cyclic Polyether Modulators of Voltage-gated Iion Channel Function

Marine Drugs, 2006
Ciguatoxins are cyclic polyether toxins, derived from marine dinoflagellates, which are responsible for the symptoms of ciguatera poisoning. Ingestion of tropical and subtropical fin fish contaminated by ciguatoxins results in an illness characterised by
Richard J. Lewis, Graham M. Nicholson
doaj   +1 more source