Results 121 to 130 of about 1,844,829 (280)

Antigen‐Detected NMR for Minimal Epitope Engineering and Structure‐Guided Selection of a NaV1.7‐Selective Nanobody

Advanced Science, EarlyView.
A minimal extracellular epitope from voltage‐gated sodium channel NaV1.7 was engineered into an isotope‐labelled antigen for antigen‐detected nuclear magnetic resonance (NMR). Together with AlphaFold2 (AF2), this enabled structure‐guided selection of R4C8, a human NaV1.7‐selective nanobody that labels fixed NaV1.7‐expressing cells and produces staining
Junyu Liu, Wanlin Chen, Ben Cristofori‐Armstrong, Theo Crawford, Kai‐En Chen, Peng Xie, Rainbow Wing Bo Chan, Yifei Zhu, Mimi Golder, Anneka Pereira Schmidt, Jennifer D. Naughton, Nicholas D. Condon, Åsa Andersson, Farhad Dehkhoda, Kirsten L. McMahon, Tabea Klasfauseweh, Ashvriya Thapa, Hue Tran, Poanna Tran, Sina Jami, Lotten Ragnarsson, Sebastian G. B. Furness, Jennifer R. Deuis, Brett M. Collins, Wai‐Hong Tham, Indira Prasadam, Irina Vetter, Mehdi Mobli   +27 more
wiley   +1 more source

Organic Electrochemical Transistors for Neuromorphic Bioelectronics: Materials and Manufacturing Technologies

Advanced Science, EarlyView.
Organic electrochemical transistors bridge biological ionic signaling and neuromorphic computation through volumetric electrochemical gating. This review connects Organic mixed ionic–electronic conductor materials, device architectures, and manufacturing technologies to show how geometry, ion transport, and fabrication strategies program plasticity ...
Hyunjin Lee, Jihyang Park, Xinyi Wang, Yueqi Deng, Jiashu Ren, Tao Zhou   +5 more
wiley   +1 more source

Ultrathin Membrane With Ion‐Specific Gating Enables Interfacial Decoupling of Conductivity–Selectivity for Aqueous Flow Batteries

Angewandte Chemie, EarlyView.
An interfacial ion‐specific gating strategy shifts membrane design from ion diffusion within ion‐exchange channels to ion partitioning at the membrane–electrolyte interface, thereby decoupling selectivity from conductivity. The strategy underscores the pivotal yet underexplored role of the membrane–electrolyte interface, providing a broadly applicable ...
Di Mu, Yu Xiong, Feiran Wang, Jiafeng Lei, Fei Ai, Jun Fan, Yi‐Chun Lu   +6 more
wiley   +2 more sources

Peptide Toxins from Marine Conus Snails with Activity on Potassium Channels and/or Currents

Toxins
Toxins from Conus snails are peptides characterized by a great structural and functional diversity. They have a high affinity for a wide range of membrane proteins such as ion channels, neurotransmitter transporters, and G protein-coupled receptors ...
Luis Martínez-Hernández, Estuardo López-Vera, Manuel B. Aguilar   +2 more
doaj   +1 more source

voltage-gated potassium channel.png

, 2016
The protein family includes 5 members: MinK, MiRP (MinK-related peptides) 1, MiRP2, MiRP3 and MiRP4, encoded by KCNE 1-5 respectively. These proteins are small type I integral membrane proteins, which can associate with and regulate various voltage-gated
Thomas Hooper (2927814)
core   +1 more source

High‐Current‐Density Acidic CO2 Electroreduction to Formic Acid Enabled by Multiscale Microenvironment Regulation Over Defect‐Rich Sn/SnOx

Advanced Science, EarlyView.
Acidic CO2 electroreduction to formic acid is enabled by integrating mixed Sn/SnOx nanoclusters, K+‐regulated interfacial solvation, and Janus wettability. Coordinated control of active sites, interfacial water, and gas‐liquid transport suppresses hydrogen evolution and delivers approximately 85% HCOOH Faradaic efficiency at 400 mA cm−2.
Qiaoqi Guo, Bowen Jiang, Le Huang, Kunyu Jiang, Rongrong Tang, Qinong Zhu, Huajun Feng, Mengyang Fan, Yijing Xia   +8 more
wiley   +1 more source

Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators

Angewandte Chemie, EarlyView.
The paper describes the serendipitous discovery of chemical manipulation allowing the activator‐to‐inhibitor switching in Kv7.2 channel modulators. The molecular determinants driving this switch have been rationalized by multidisciplinary investigation encompassing synthetic and analytical chemistry, in silico methods, cryo‐EM analysis ...
Tania Ciaglia, Giusy Carleo, Zhenni Yang, Francesca Di Matteo, Federica De Rosa, Gerardina Smaldone, Zhao‐Bing Gao, Marco D'Alì, Rita Turcio, Demin Ma, Veronica Di Sarno, Nannan Su, Salvatore Vincenzo Giofrè, Giacomo Pepe, Pietro Campiglia, Alessia Bertamino, Francesco Miceli, Jiangtao Guo, Nunzio Iraci, Carmine Ostacolo, Maurizio Taglialatela   +20 more
wiley   +2 more sources

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

Electrically Tuning Electromagnetic Wave Shielding in Phase Engineered 1T/2H‐MoS2‐Based Devices

Advanced Electronic Materials, EarlyView.
Sub‐millimeter‐thick phase‐engineered 1T/2H‐MoS2 structures enable electrically tunable electromagnetic interference shielding through active modulation of microwave absorption and reflection. The coexistence of metallic and semiconducting phases, combined with a PVA/KOH gel electrolyte, provides dynamic control over charge transport and interfacial ...
Mustafa Akyol, Atalay Bozdogan, Hakan Eroglu, Muharrem Karaaslan   +3 more
wiley   +1 more source

Smart Exploration of Perovskite Photovoltaics: From AI Driven Discovery to Autonomous Laboratories

Advanced Energy Materials, EarlyView.
In this review, we summarize the fundamentals of AI in automated materials science, and review AI applications in perovskite solar cells. Then, we sum up recent progress in AI‐guided manufacturing optimization, and highlight AI‐driven high‐throughput and autonomous laboratories.
Wenning Chen, Zheyu Zhang, Kelvian T. Mularso, Bonghyun Jo, Hyun Suk Jung   +4 more
wiley   +1 more source