Results 121 to 130 of about 65,085 (300)

Ion trapping with fast-response ion-selective microelectrodes enhances detection of extracellular ion channel gradients [PDF]

, 2008
Previously, functional mapping of channels has been achieved by measuring the passage of net charge and of specific ions with electrophysiological and intracellular fluorescence imaging techniques.
Collis, Leon P., Smith, Peter J. S., Messerli, Mark A., Smith, Peter J.S.   +3 more
core   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

Developmental expression of Kv potassium channels at the axon initial segment of cultured hippocampal neurons.

PLoS ONE, 2012
Axonal outgrowth and the formation of the axon initial segment (AIS) are early events in the acquisition of neuronal polarity. The AIS is characterized by a high concentration of voltage-dependent sodium and potassium channels.
Diana Sánchez-Ponce, Javier DeFelipe, Juan José Garrido, Alberto Muñoz   +3 more
doaj   +1 more source

International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels

, 2003
This summary article presents an overview of the molecular relationships among the voltage-gated potassium channels and a standard nomenclature for them, which is derived from the IUPHAR Compendium of Voltage-Gated Ion Channels.
McKinnon, D., Wei, A, Rudy, B, Vandenberg, C A, Florian Lesage, Kurachi, Y., Jonathan Robbins, Lesage, Florian, Andreas Karschin, Karschin, A., Wulff, Heike, Robertson, G., Ganetzky, B, Desir, G V, Stuehmer, W, Covarriubias, Manuel, O'Kelly, Ita, Chandy, K., Garcia, M L, Adelman, John P., K. George Chandy, Bayliss, Douglas A., Vandenberg, C., Clapham, D E, Mckinnon, D, Ganetzky, Barry, Nichols, C., Kurachi, Yoshihisa, Carol A. Vandenberg, Stühmer, Walter, Yoshihisa Kurachi, O'Kelly, I, Stühmer, W., Gail A. Robertson, Lester, H., Walter Stuehmer, John P. Adelman, Barry Ganetzky, Lazdunski, M, Wymore, R., Covarriubias, M., Garcia, M., Wei, A., O'Kelly, I., Sanguinetti, Michael, Tamkun, M., Aiyar, J, Grissmer, Stephan, Sabina Kuperschmidt, Michael Sanguinetti, Sanguinetti, M., Karschin, Andreas, Karschin, A, Nichols, C G, Chandy, K. George, Vandenberg, Carol A., Michel Lazdunski, S. Wymore, Rudy, B., Seino, S, Randy, Sanguinetti, M, Stuehmer, Walter, Donghee Kim, Robertson, Gail A., Jan, L., Jan, L Y, Adelman, J P, Robbins, J., Lester, Henry A., Furuichi, K., Colin G. Nichols, Wymore, R S, Tamkun, M M, Gutman, G A, Garcia, Maria L., Wei, Aguan, Clapham, D., Lester, H A, Kuperschmidt, S, Tamkun, Michael M., Michael M. Tamkun, Aiyar, Jayashree, Desir, Gary V., Lesage, F, Kurachi, Y, Aguan Wei, Robbins, Jonathan, Jayashree Aiyar, Chandy, K.George, David Mckinnon, Desir, G., Bayliss, D A, Furuichi, Kiyoshi, Kim, D, Stephan Grissmer, Rudy, Bernardo, Kim, D., Kiyoshi Furuichi, Seino, S., Robbins, J, Lazdunski, Michel, Bayliss, D., Wulff, H., Gutman, George A., Wymore, Randy S., Kuperschmidt, Sabina, Jan, Lily Y., Henry A. Lester, Ganetzky, B., Douglas A. Bayliss, Nichols, Colin G., George A. Gutman, Lily Y. Jan, Chandy, K G, Covarriubias, M, Aiyar, J., Gary V. Desir, Maria L. Garcia, Manuel Covarriubias, Lazdunski, M., Seino, Susumu, Bernardo Rudy, Grissmer, S, Furuichi, K, McKinnon, David, Wulff, H, Gutman, G., Kuperschmidt, S., Lesage, F., Kim, Donghee, Grissmer, S., Heike Wulff, Adelman, J., Clapham, David E., David E. Clapham, Susumu Seino, Robertson, G A   +137 more
core   +2 more sources

Smart Exploration of Perovskite Photovoltaics: From AI Driven Discovery to Autonomous Laboratories

Advanced Energy Materials, EarlyView.
In this review, we summarize the fundamentals of AI in automated materials science, and review AI applications in perovskite solar cells. Then, we sum up recent progress in AI‐guided manufacturing optimization, and highlight AI‐driven high‐throughput and autonomous laboratories.
Wenning Chen, Zheyu Zhang, Kelvian T. Mularso, Bonghyun Jo, Hyun Suk Jung   +4 more
wiley   +1 more source

Exploring the therapeutic opportunities of potassium channels for the treatment of rheumatoid arthritis

Frontiers in Pharmacology
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects the synovial joint, which leads to inflammation, loss of function, joint destruction, and disability.
Nikhil Eknath More, Rahul Mandlik, Sandip Zine, Vaibhavkumar S. Gawali, Angel Pavalu Godad, Angel Pavalu Godad   +5 more
doaj   +1 more source

Main‐Chain Ion‐Pair Polybenzimidazole Membranes Enabling Reduced‐Temperature HT‐PEMFC Operation (Down to 120°C)

Advanced Energy Materials, EarlyView.
Embedding imidazolium‐biphosphate ion pairs directly into the polybenzimidazole main chain simultaneously stabilizes phosphoric acid and preserves continuous proton transport pathways. Strong ion‐pair and hydrogen‐bond interactions suppress acid leaching while maintaining high conductivity, enabling stable and durable high‐temperature fuel cell ...
Huina Lin, Brian C. Benicewicz
wiley   +1 more source

PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gating

Frontiers in Physiology, 2014
Voltage-gated potassium (Kv) channels contain voltage-sensing (VSD) and pore-gate (PGD) structural domains. During voltage-dependent gating, conformational changes in the two domains are coupled giving rise to voltage-dependent opening of the channel. In
Mark Alan Zaydman, Jianmin eCui
doaj   +1 more source

Parametric Analysis of Spiking Neurons in 16 nm Fin Field‐Effect Transistor Technology

Advanced Intelligent Discovery, EarlyView.
Energy efficient computing has driven a shift toward brain‐inspired neuromorphic hardware. This study explores the design of three distinct silicon neuron topologies implemented in 16 nm fin field‐Effect transistor technology. While the Axon‐Hillock design achieves gigahertz throughput, its functional fragility persists. The Morris–Lecar model captures
Logan Larsh, Raiyan Siddique, Sarah S. Sharif, Yaser Mike Banad   +3 more
wiley   +1 more source

Biochemical and Immunohistochemical Associations of TDP‐43 and Cryptic RNA With Hippocampal and Amygdala Volumetrics in Alzheimer's Disease

Annals of Neurology, EarlyView.
Objective Immunohistochemically (IHC) measured transactive response DNA‐binding protein 43 (TDP‐43) inclusions are observed in Alzheimer's disease (AD) and are associated with medial temporal lobe atrophy. Accumulation of cryptic exons occurs in AD in response to TDP‐43 pathology.
Hossam Youssef, Rodolfo G. Gatto, Nikhil B. Ghayal, Virginia Estades Ayuso, Karen R. Jansen‐West, Judith A. Dunmore, Yuping Song, Mei Yue, Casey N. Cook, Michael DeTure, Bailey D. Rawlinson, Monica Castanedes‐Casey, Clifford R. Jack Jr, Ronald C. Petersen, Dennis W. Dickson, Leonard Petrucelli, Jennifer L. Whitwell, Mercedes Prudencio, Keith A. Josephs   +18 more
wiley   +1 more source