Results 11 to 20 of about 57,429 (242)
Heliyon, 2023 Osteoarthritis (OA) is one of the leading causes of chronic pain and dysfunction. It is essential to comprehend the nature of pain and cartilage degeneration and its influencing factors on OA treatment. Voltage-gated ion channels (VGICs) are essential in
Xinwei Wang, Xueping Li
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Voltage-Gated Potassium Channels as Regulators of Cell Death
Frontiers in Cell and Developmental Biology, 2020 Ion channels allow the flux of specific ions across biological membranes, thereby determining ion homeostasis within the cells. Voltage-gated potassium-selective ion channels crucially contribute to the setting of the plasma membrane potential, to volume
Magdalena Bachmann +9 more
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Photocontrol of Voltage-Gated Ion Channel Activity by Azobenzene Trimethylammonium Bromide in Neonatal Rat Cardiomyocytes. [PDF]
PLoS ONE, 2016 The ability of azobenzene trimethylammonium bromide (azoTAB) to sensitize cardiac tissue excitability to light was recently reported. The dark, thermally relaxed trans- isomer of azoTAB suppressed spontaneous activity and excitation propagation speed ...
Sheyda R Frolova +4 more
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Oxidative Modulation of Voltage-Gated Potassium Channels [PDF]
Antioxidants & Redox Signaling, 2014 Voltage-gated K+ channels are a large family of K+-selective ion channel protein complexes that open on membrane depolarization. These K+ channels are expressed in diverse tissues and their function is vital for numerous physiological processes, in particular of neurons and muscle cells.
Nirakar, Sahoo +2 more
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Marine Drugs, 2022 Sea anemones are a rich source of biologically active compounds. Among approximately 1100 species described so far, Heteractis crispa species, also known as sebae anemone, is native to the Indo-Pacific area.
Ernesto Lopes Pinheiro-Junior +5 more
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Voltage-gated potassium channels as therapeutic targets [PDF]
Nature Reviews Drug Discovery, 2009 The human genome encodes 40 voltage-gated K(+) channels (K(V)), which are involved in diverse physiological processes ranging from repolarization of neuronal and cardiac action potentials, to regulating Ca(2+) signalling and cell volume, to driving cellular proliferation and migration. K(V) channels offer tremendous opportunities for the development of
Wulff, H., Castle, N., Pardo, L.
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Nature Communications, 2017 Dysregulation of voltage gated potassium channels is a feature of neuropathic pain. Here in a rat model the authors identify the microRNA cluster miR-17-92 as a regulator of voltage gated potassium channels in the dorsal root ganglion neurons.
Atsushi Sakai +7 more
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Toxins, 2016 The Zoanthids are an order of cnidarians whose venoms and toxins have been poorly studied. Palythoa caribaeorum is a zoanthid commonly found around the Mexican coastline. In this study, we tested the activity of P.
Fernando Lazcano-Pérez +5 more
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Photochromic Blockers of Voltage‐Gated Potassium Channels [PDF]
Angewandte Chemie International Edition, 2009 Photochromic ligands (PCLs) can be optically switchedbetween isomers that show different biological activities. Assuch, they offer an opportunity to convert ligand-actuatedpathways into light-actuated pathways, thus making it possi-ble to control a wide range of biological processes with light.PCLs have been explored for various classes of ...
Matthew R, Banghart +5 more
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Frontiers in Cellular Neuroscience, 2019 Voltage-gated ion channels are essential for signal generation and propagation in neurons and other excitable cells. The high-voltage activated calcium-channel Cav2.3 is expressed throughout the central and peripheral nervous system, and within CA1 ...
Jakob J. Gutzmann +2 more
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