Results 21 to 30 of about 1,936,204 (283)
Beta1 subunits enable fentanyl-induced BK channel activation and opioid regulation of cerebral artery diameter. [PDF]
FEBS Open BioDuring the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Thapa S +4 more
europepmc +2 more sources
Structure and function of potassium and calcium channels [PDF]
, 2005 In this thesis, potassium channels human Kv2.1 and rat Kv2.1, along with calcium channels Ca, 1.2, Ca, 3.1, and chimeras have been studied. These channels were expressed in Xenopuso ocytesf or electrophysiological experiments using two electrode voltage
Stevens, Louisa Rebecca
core +7 more sources
The role of axonal voltage-gated potassium channels in tDCS
Brain Stimulation, 2022 Background: Transcranial direct current stimulation (tDCS) is a non-invasive sub-threshold stimulation, widely accepted for its amelioration of distinct neuropsychiatric disorders.
Sreerag Othayoth Vasu, Hanoch Kaphzan
doaj +1 more source
Modeling the kinetics of heteromeric potassium channels
Frontiers in Cellular Neuroscience, 2022 Mechanistic mathematical modeling has long been used as a tool for answering questions in cellular physiology. To mathematically describe cellular processes such as cell excitability, volume regulation, neurotransmitter release, and hormone secretion ...
Kees McGahan, James Keener
doaj +1 more source
Mechanisms of Activation of Voltage-Gated Potassium Channels [PDF]
Acta Naturae, 2014 Voltage-gated potassium ion channels (Kv) play an important role in a variety of cellular processes, including the functioning of excitable cells, regulation of apoptosis, cell growth and differentiation, the release of neurotransmitters and hormones, maintenance of cardiac activity, etc.
GRIZEL A.V., GLUKHOV G.S., SOKOLOVA O.S.
openaire +4 more sources
Functional reconstitution of a voltage-gated potassium channel in giant unilamellar vesicles. [PDF]
PLoS ONE, 2011 Voltage-gated ion channels are key players in cellular excitability. Recent studies suggest that their behavior can depend strongly on the membrane lipid composition and physical state. In vivo studies of membrane/channel and channel/channel interactions
Sophie Aimon +5 more
doaj +1 more source
Heliyon, 2023 Osteoarthritis (OA) is one of the leading causes of chronic pain and dysfunction. It is essential to comprehend the nature of pain and cartilage degeneration and its influencing factors on OA treatment. Voltage-gated ion channels (VGICs) are essential in
Xinwei Wang, Xueping Li
doaj +1 more source
Role of Kv1 potassium channels in regulating dopamine release and presynaptic D2 receptor function. [PDF]
PLoS ONE, 2011 Dopamine (DA) release in the CNS is critical for motor control and motivated behaviors. Dysfunction of its regulation is thought to be implicated in drug abuse and in diseases such as schizophrenia and Parkinson's.
Philippe Martel +4 more
doaj +1 more source
Oxidative Modulation of Voltage-Gated Potassium Channels [PDF]
Antioxidants & Redox Signaling, 2014 Significance: Voltage-gated K + channels are a large family of K + -selective ion channel protein complexes that open on membrane depolarization. These K +
Nirakar, Sahoo +2 more
openaire +2 more sources
KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel α-subunit composition [PDF]
, 2011 Voltage-gated potassium (Kv) currents generated by N-type α-subunit homotetramers inactivate rapidly because an N-terminal ball domain blocks the channel pore after activation.
Abbott, G. +10 more
core +1 more source