Results 41 to 50 of about 1,936,204 (283)

Functional Coupling of Cav2.3 and BK Potassium Channels Regulates Action Potential Repolarization and Short-Term Plasticity in the Mouse Hippocampus

Frontiers in Cellular Neuroscience, 2019
Voltage-gated ion channels are essential for signal generation and propagation in neurons and other excitable cells. The high-voltage activated calcium-channel Cav2.3 is expressed throughout the central and peripheral nervous system, and within CA1 ...
Jakob J. Gutzmann, Lin Lin, Dax A. Hoffman   +2 more
doaj   +1 more source

A nongenomic mechanism for progesterone-mediated immunosuppression: Inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes [PDF]

, 1998
The mechanism by which progesterone causes localized suppression of the immune response during pregnancy has remained elusive. Using human T lymphocytes and T cell lines, we show that progesterone, at concentrations found in the placenta, rapidly and ...
Christopher M. Fanger, Khoury, Rosana M, Negulescu, Paul A, Cahalan, Michael D, Neben, Amber L, Hubert H. Kerschbaum, Fanger, Christopher M, Rosana M. Khoury, Kerschbaum, Hubert H, Claudia Eder, Amber L. Neben, George R. Ehring, Eder, Claudia, Michael D. Cahalan, Paul A. Negulescu, Ehring, George R, Negulescu, PA, Fanger, CM, Kerschbaum, HH, Khoury, RM, Ehring, GR, Eder, C, Cahalan, MD, Neben, AL   +23 more
core   +1 more source

Role of potassium conductance in mechanisms of exrtacellular atp impact on the contractive activity of vascular smooth muscle cells

Бюллетень сибирской медицины, 2017
The purpose of this work is to study the influence of extracellular ATP (adenosine-3-phosphate), which is an activator of purinergic receptors, on contractive activity of rat aortic ring segments precontracted by α1-adrenoreceptors activation with ...
S. N. Orlov, L. V. Smagliy, S. V. Gusakova, V. S. Rydchenko, Yu. G. Birulina, A. N. Baikov, V. N. Vasiliyev, G. A. Sukhanova, T. S. Fedorova, T. V. Lasukova   +9 more
doaj   +1 more source

Computational identification of residues that modulate voltage sensitivity of voltage-gated potassium channels [PDF]

, 2005
Background: Studies of the structure-function relationship in proteins for which no 3D structure is available are often based on inspection of multiple sequence alignments.
Li, B., Gallin, W.J.
core   +1 more source

Light-Induced Control of Voltage Gated Ion Channels [PDF]

, 2022
Voltage gated ion channels are transmembrane proteins responsible for the generation and propagation of action potentials in excitable cells. They are key targets in receptor pharmacology, since the simple actions of opening and closing their pore with ...
Shirin, Faraji, Vito F., Palmisano, Nuria, Anguita-Ortiz, Juan Jose, Nogueira, Juan Jose Nogueira, Shirin Faraji, Vito F. Palmisano, Nuria Anguita-Ortiz   +7 more
core   +1 more source

Role of Voltage-gated Potassium Channels in Cancer

The Journal of Membrane Biology, 2005
Ion channels are being associated with a growing number of diseases including cancer. This overview summarizes data on voltage-gated potassium channels (VGKCs) that exhibit oncogenic properties: ether-à-go-go type 1 (Eag1). Normally, Eag1 is expressed almost exclusively in tissue of neural origin, but its ectopic expression leads to uncontrolled ...
Pardo, L. A., Contreras-Jurado, C., Zientkowska, M., Alves, Frauke, Stühmer, W.   +4 more
openaire   +5 more sources

Contribution of voltage‐gated potassium channels to the regulation of apoptosis [PDF]

FEBS Letters, 2010
Recent evidence points to the crucial involvement of voltage‐gated potassium channels (Kv) in apoptotic volume decrease and in the regulation of apoptosis in several systems. We have recently described the presence of a Kv channel, Kv1.3, in the mitochondria of lymphocytes.
SZABO', ILDIKO', ZORATTI M, GULBINS E.
openaire   +5 more sources

C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels. [PDF]

PLoS ONE, 2013
Kv11.1 potassium channels are important for regulation of the normal rhythm of the heartbeat. Reduced activity of Kv11.1 channels causes long QT syndrome type 2, a disorder that increases the risk of cardiac arrhythmias and sudden cardiac arrest.
Chai Ann Ng, Ying Ke, Matthew D Perry, Peter S Tan, Adam P Hill, Jamie I Vandenberg   +5 more
doaj   +1 more source

The response of the tandem pore potassium channel TASK-3 (K2P9.1) to voltage : gating at the cytoplasmic mouth [PDF]

, 2009
Although the tandem pore potassium channel TASK-3 is thought to open and shut at its selectivity filter in response to changes of extracellular pH, it is currently unknown whether the channel also shows gating at its inner, cytoplasmic mouth through ...
Feng, J. F., Puja R. Mehta, Sutcliffe, M. J., M. J. Sutcliffe, Mehta, Puja R., Stanfield, P. R., Stanfield, Peter R., Stansfeld, P. J., Feng, J.F., Sutcliffe, M.J., Vavoulis, Dimitris V., Mehta, Puja, R., Vavoulis, D. V., Ashmole, I., Stansfeld, P.J., Feng, Jianfeng, Stansfeld, Phillip J., I. Ashmole, J. F. Feng, P. J. Stansfeld, Vavoulis, D.V., D. V. Vavoulis, P. R. Stanfield, Stanfield, P.R.   +23 more
core   +1 more source

Behavior of ion channels controlled by electric potential difference and of Toll-type receptors in neuropathic pain pathophysiology

Revista Dor
BACKGROUND AND OBJECTIVES: Neuropathic pain is a severe and refractory medical condition, for which only partially effective treatments are currently available.
André Prato Schmidt, Sérgio Renato Guimarães Schmidt   +1 more
doaj   +1 more source