Results 51 to 60 of about 65,085 (300)

Voltage-gated potassium channels as a potential therapeutic target for the treatment of neurological and psychiatric disorders

Frontiers in Cellular Neuroscience
Voltage-gated potassium channels are a widely distributed subgroup of potassium channels responsible for the efflux of potassium in the repolarisation of the cell membrane, and hence contribute to the latency and propagation of action potentials. As they
Isabel E. Faulkner, Rachael Z. Pajak, Michael K. Harte, Jocelyn D. Glazier, Reinmar Hager   +4 more
doaj   +1 more source

Direct neurotransmitter activation of voltage-gated potassium channels

Nature Communications, 2018
M-current is conveyed by voltage-sensitive KCNQ channels, which are enriched in GABAergic neurons and are activated by anticonvulsants such as retigabine.
Rían W. Manville, Maria Papanikolaou, Geoffrey W. Abbott   +2 more
doaj   +1 more source

Dual Regulation of Voltage-Sensitive Ion Channels by PIP2

Frontiers in Pharmacology, 2012
Over the past 16 years, there has been an impressive number of ion channels shown to be sensitive to the major phosphoinositide in the plasma membrane, phosphatidilinositol 4,5-bisphosphate (PIP2). Among them are voltage-gated channels, which are crucial
Aldo A Rodríguez Menchaca, Scott K Adney, Lei eZhou, Diomedes E Logothetis   +3 more
doaj   +1 more source

Analysis of a putative voltage‐gated prokaryotic potassium channel [PDF]

European Journal of Biochemistry, 2001
Most of the completely sequenced prokaryotic genomes contain genes of potassium channel homologues, but there is still not much known about the role of these proteins in prokaryotes. Here we describe the large‐scale overproduction and purification of a prokaryotic voltage‐gated potassium channel homologue, Kch, from Escherichia coli.
Ungar, D., Barth, A., Haase, W., Kaunzinger, A., Lewitzki, E., Ruiz, T., Reiländer, H., Michel, H.   +7 more
openaire   +4 more sources

Can the Thermodynamic Hodgkin-Huxley Model of Voltage-Dependent Conductance Extrapolate for Temperature? [PDF]

, 2014
Hodgkin and Huxley (H-H) fitted their model of voltage-dependent conductances to experimental data using empirical functions of voltage. The thermodynamic H-H model of voltage dependent conductances is more physically plausible, as it constrains and ...
Michael D. Forrest, Forrest, Michael D., Michael Forrest   +2 more
core   +1 more source

Ferroelectric Quantum Dots for Retinomorphic In‐Sensor Computing

Advanced Materials, EarlyView.
This work has provided a protocol for fabricating retinomorphic phototransistors by integrating ferroelectric ligands with quantum dots. The resulting device combines ferroelectricity, optical responsiveness, and low‐power operation to enable adaptive signal amplification and high recognition accuracy under low‐light conditions, while supporting ...
Tingyu Long, Huanyu Zhou, Jaewan Ko, Hongwei Tan, Jaemin Lim, Yanfei Zhao, Daehan Kang, Eojin Yoon, Gyeong‐Tak Go, Somin Kim, Seung‐Woo Lee, Chan‐Yul Park, Hyojun Choi, Hyeran Kim, Hyung Joong Yun, Sung Hyuk Park, Kwan Sik Park, Jeong Woo Park, Mungeun Kim, Yong Soo Cho, Ho Won Jang, Wenqiang Yang, Min Hyuk Park, Wan Ki Bae, Sebastiaan van Dijken, Joona Bang, Tae‐Woo Lee   +26 more
wiley   +1 more source

Contribution of Axon Initial Segment Structure and Channels to Brain Pathology

Cells, 2023
Brain channelopathies are a group of neurological disorders that result from genetic mutations affecting ion channels in the brain. Ion channels are specialized proteins that play a crucial role in the electrical activity of nerve cells by controlling ...
Juan José Garrido
doaj   +1 more source

Kv2.1 voltage‐gated potassium channels in developmental perspective [PDF]

Developmental Dynamics, 2019
AbstractKv2.1 voltage‐gated potassium channels consist of two types of α‐subunits: (a) electrically‐active Kcnb1 α‐subunits and (b) silent or modulatory α‐subunits plus β‐subunits that, similar to silent α‐subunits, also regulate electrically‐active subunits. Voltage‐gated potassium channels were traditionally viewed, mainly by electrophysiologists, as
Justyna Jędrychowska, Vladimir Korzh
openaire   +2 more sources

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

A subfraction obtained from the venom of the tarantula Poecilotheria regalis contains inhibitor cystine knot peptides and induces relaxation of rat aorta by inhibiting L-type voltage-gated calcium channels

Toxicon: X, 2023
Venoms from tarantulas contain low molecular weight vasodilatory compounds whose biological action is conceived as part of the envenomation strategy due to its propagative effects. However, some properties of venom-induced vasodilation do not match those
Luis Fernando Díaz-Peña, Torres-Ortiz Daniela, Manuel B. Aguilar, Enoch Luis, Fernando Lazcano-Pérez, Roberto Arreguín-Espinosa, Arturo Hernandez-Cruz, César Ibarra-Alvarado, Alejandro García-Arredondo   +8 more
doaj   +1 more source