Results 11 to 20 of about 1,231,807 (284)

When Is a Potassium Channel Not a Potassium Channel?

Function, 2022
Ever since they were first observed in Purkinje fibers of the heart, funny channels have had close connections to potassium channels. Indeed, funny channels were initially thought to produce a potassium current in the heart called IK2.
Eric Accili
doaj   +3 more sources

Potassium channels [PDF]

FEBS Letters, 2003
The atomic structures of K+ channels have added a new dimension to our understanding of K+ channel function. I will briefly review how structures have influenced our views on ion conduction, gating of the pore, and voltage sensing.
Roderick Mackinnon
exaly   +3 more sources

Mitochondrial Potassium Channels as Druggable Targets

Biomolecules, 2020
Mitochondrial potassium channels have been described as important factors in cell pro-life and death phenomena. The activation of mitochondrial potassium channels, such as ATP-regulated or calcium-activated large conductance potassium channels, may have ...
Antoni Wrzosek, Bartłomiej Augustynek, Monika Żochowska, Adam Szewczyk   +3 more
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Alternative Targets for Modulators of Mitochondrial Potassium Channels

Molecules, 2022
Mitochondrial potassium channels control potassium influx into the mitochondrial matrix and thus regulate mitochondrial membrane potential, volume, respiration, and synthesis of reactive oxygen species (ROS).
Antoni Wrzosek, Shur Gałecka, Monika Żochowska, Anna Olszewska, Bogusz Kulawiak   +4 more
doaj   +3 more sources

Hydrogen Sulfide-Induced Vasodilation: The Involvement of Vascular Potassium Channels

Frontiers in Pharmacology, 2022
Hydrogen sulfide (H2S) has been highlighted as an important gasotransmitter in mammals. A growing number of studies have indicated that H2S plays a key role in the pathophysiology of vascular diseases and physiological vascular homeostasis. Alteration in
Xiao-Yu Liu, Ling-Ling Qian, Ru-Xing Wang   +2 more
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Potassium channels in depression: emerging roles and potential targets [PDF]

Cell & Bioscience
Potassium ion channels play a fundamental role in regulating cell membrane repolarization, modulating the frequency and shape of action potentials, and maintaining the resting membrane potential.
Jiahao Zhang, Yao Zhu, Meng Zhang, Jinglan Yan, Yuanjia Zheng, Lin Yao, Ziwei Li, Zihan Shao, Yongjun Chen   +8 more
doaj   +2 more sources

Pharmacological Actions of Potassium Channel Openers on Voltage-Gated Potassium Channels [PDF]

Pharmaceuticals
Background/Objectives: Potassium (K+) channels are essential transmembrane proteins that regulate ion flow, playing a critical role in regulating action potentials and neuronal transmission.
Michael T. McCoy, Bruce Ladenheim, Jean Lud Cadet, Atul P. Daiwile   +3 more
doaj   +2 more sources

Structure and function of potassium and calcium channels [PDF]

, 2005
In this thesis, potassium channels human Kv2.1 and rat Kv2.1, along with calcium channels Ca, 1.2, Ca, 3.1, and chimeras have been studied. These channels were expressed in Xenopuso ocytesf or electrophysiological experiments using two electrode voltage
Stevens, Louisa Rebecca
core   +7 more sources

Membrane trafficking of ATP-sensitive potassium channels [PDF]

, 2005
ATP-sensitive potassium (KATp) channels are known to play a vital role in the regulation of insulin secretion from pancreatic 0-cells. Changes in the ratio of [ATP]/[ADP] within the cell are known to regulate the activity of channels, but very little is ...
Smith, Andrew James
core   +7 more sources

Ca²⁺-Sensitive Potassium Channels

Molecules, 2023
The Ca2+ ion is used ubiquitously as an intracellular signaling molecule due to its high external and low internal concentration. Many Ca2+-sensing ion channel proteins have evolved to receive and propagate Ca2+ signals. Among them are the Ca2+-activated
Razan Orfali, Nora Albanyan
doaj   +1 more source