Results 11 to 20 of about 1,282,561 (289)
Structure of potassium channels [PDF]
Cellular and Molecular Life Sciences, 2015 Potassium channels ubiquitously exist in nearly all kingdoms of life and perform diverse but important functions. Since the first atomic structure of a prokaryotic potassium channel (KcsA, a channel from Streptomyces lividans) was determined, tremendous progress has been made in understanding the mechanism of potassium channels and channels conducting ...
Qie Kuang, Pasi Purhonen, Hans Hebert
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Membrane trafficking of ATP-sensitive potassium channels [PDF]
, 2005 ATP-sensitive potassium (KATp) channels are known to play a vital role in the regulation of insulin secretion from pancreatic 0-cells. Changes in the ratio of [ATP]/[ADP] within the cell are known to regulate the activity of channels, but very little is ...
Smith, Andrew James
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Structure and function of potassium and calcium channels [PDF]
, 2005 In this thesis, potassium channels human Kv2.1 and rat Kv2.1, along with calcium channels Ca, 1.2, Ca, 3.1, and chimeras have been studied. These channels were expressed in Xenopuso ocytesf or electrophysiological experiments using two electrode voltage
Stevens, Louisa Rebecca
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Drunk potassium channels [PDF]
Europace, 2011 We report the case of a 42-year-old woman who was admitted due to alcohol induced dehydration leading to cardiac symptoms. On physical examination severe hypokalaemia and long QT syndrome were apparent. During potassium (K+) supplementation we simultaneously observed QT interval recovery.
Amir M, Nia +3 more
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Potassium Channels in Epilepsy [PDF]
Cold Spring Harbor Perspectives in Medicine, 2016 This review attempts to give a concise and up-to-date overview on the role of potassium channels in epilepsies. Their role can be defined from a genetic perspective, focusing on variants and de novo mutations identified in genetic studies or animal models with targeted, specific mutations in genes coding for a member of the large potassium channel ...
Rüdiger, Köhling, Jakob, Wolfart
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FEBS Letters, 2003 The atomic structures of K+ channels have added a new dimension to our understanding of K+ channel function. I will briefly review how structures have influenced our views on ion conduction, gating of the pore, and voltage sensing.
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The neuroglial potassium cycle during neurotransmission: role of Kir4.1 channels. [PDF]
PLoS Computational Biology, 2015 Neuronal excitability relies on inward sodium and outward potassium fluxes during action potentials. To prevent neuronal hyperexcitability, potassium ions have to be taken up quickly.
Jérémie Sibille +3 more
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Frontiers in Pharmacology, 2017 The natural flavone acacetin inhibits several voltage-gated potassium currents in atrial myocytes, and has anti-atrial fibrillation (AF) effect in experimental AF models.
Kui-Hao Chen +9 more
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Potassium Ion Channels in Glioma: From Basic Knowledge into Therapeutic Applications
Membranes, 2023 Ion channels, specifically those controlling the flux of potassium across cell membranes, have recently been shown to exhibit an important role in the pathophysiology of glioma, the most common primary central nervous system tumor with a poor prognosis ...
Samar Younes +4 more
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Potassium channels in prostate and colonic cancer [PDF]
, 2007 Large conductance Ca2+-activated K+ channels in human prostate cancer The KCNMA1 gene encoding the alpha-subunit of BK channels is amplified and BK channel expression is enhanced in late-stage, metastatic and hormone-refractory human prostate cancer ...
Ousingsawat, Jiraporn
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