Effect of channel block on the spiking activity of excitable membranes in a stochastic Hodgkin-Huxley model [PDF]
, 2004 The influence of intrinsic channel noise on the spontaneous spiking activity of poisoned excitable membrane patches is studied by use of a stochastic generalization of the Hodgkin-Huxley model.
Chow C C +17 more
core +2 more sources
Data in Brief, 2021 In the present work, applying the whole-cell patch-clamp technique in voltage clamp mode, we have investigated the effects of different drugs, such as riluzole, Psora-4 and Tram-34, on the potassium currents in four human lymphoma cell lines.
Alberto Montalbano +8 more
doaj +1 more source
Genomic organization and chromosomal localization of the murine 2 P domain potassium channel gene Kcnk8: conservation of gene structure in 2 P domain potassium channels. [PDF]
, 2000 A 2 P domain potassium channel expressed in eye, lung, and stomach, Kcnk8, has recently been identified. To initiate further biochemical and genetic studies of this channel, we assembled the murine Kcnk8 cDNA sequence, characterized the genomic structure
Bockenhauer, D +4 more
core +1 more source
Potassium Channels in Epilepsy [PDF]
Cold Spring Harbor Perspectives in Medicine, 2016 This review attempts to give a concise and up-to-date overview on the role of potassium channels in epilepsies. Their role can be defined from a genetic perspective, focusing on variants and de novo mutations identified in genetic studies or animal models with targeted, specific mutations in genes coding for a member of the large potassium channel ...
Rüdiger, Köhling, Jakob, Wolfart
openaire +2 more sources
Role of potassium channels in female reproductive system [PDF]
Obstetrics & Gynecology Science, 2020 Potassium channels are widely expressed in most types of cells in living organisms and regulate the functions of a variety of organs, including kidneys, neurons, cardiovascular organs, and pancreas among others. However, the functional roles of potassium
Jun-Mo Kim +3 more
doaj +1 more source
Potassium channels as drugs targets in therapy of cardiovascular diseases: 25 years later [PDF]
Sanamed, 2013 Potassium channels are the most variable ion channel group. They participate in numerous cardiovascular functions, for example regulation of vascular tone, maintenance of resting cardiac membrane potential and excitability of cardiac conduction tissue ...
Protić Dragana +2 more
doaj +2 more sources
Feshbach resonances in potassium Bose-Bose mixtures
, 2018 We present a detailed study of the scattering properties of ultracold mixtures of bosonic potassium atoms. We locate 20 previously unobserved Feshbach resonances in isotopic 39K-41K mixtures.
Cabrera, C. R. +5 more
core +1 more source
Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3. [PDF]
, 2000 Potassium leak conductances were recently revealed to exist as independent molecular entities. Here, the genomic structure, cardiac localization, and biophysical properties of a murine example are considered.
Buck, ME +4 more
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Single-channel recordings from cultured human retinal pigment epithelial cells. [PDF]
, 1988 We have applied patch-clamp techniques to on-cell and excised-membrane patches from human retinal pigment epithelial cells in tissue culture. Single-channel currents from at least four ion channel types were observed: three or more potassium-selective ...
Fain, GL, Fox, JA, Pfeffer, BA
core