Results 21 to 30 of about 1,282,561 (289)

Role of Kv1 potassium channels in regulating dopamine release and presynaptic D2 receptor function. [PDF]

PLoS ONE, 2011
Dopamine (DA) release in the CNS is critical for motor control and motivated behaviors. Dysfunction of its regulation is thought to be implicated in drug abuse and in diseases such as schizophrenia and Parkinson's.
Philippe Martel, Damiana Leo, Stephanie Fulton, Maxime Bérard, Louis-Eric Trudeau   +4 more
doaj   +1 more source

Distinct Distribution Patterns of Potassium Channel Sub-Units in Somato-Dendritic Compartments of Neurons of the Medial Superior Olive

Frontiers in Cellular Neuroscience, 2019
Coincidence detector neurons of the medial superior olive (MSO) are sensitive to interaural time differences in the range of a few tens of microseconds. The biophysical basis for this remarkable acuity is a short integration time constant of the membrane,
Alisha L. Nabel, Alisha L. Nabel, Alexander R. Callan, Alexander R. Callan, Sarah A. Gleiss, Sarah A. Gleiss, Nikolaos Kladisios, Christian Leibold, Felix Felmy, Felix Felmy   +9 more
doaj   +1 more source

What have we learned from two-pore potassium channels? Their molecular configuration and function in the human heart [PDF]

, 2012
Two-pore domain potassium channels (K2P) control excitability, stabilize the resting membrane potential below firing threshold, and accelerate repolarisation in different cells.
Szalontai, B., Ötvös, Ferenc, Benyhe, S., Boyett, M., Vágvölgyi, Csaba, Szûts, V., Papp, J.G., Dobrzynski, H.; id_orcid, Szüts, Viktória, Dézsi, László, Szalontai, Balázs, Dobrzynski, Halina, Zhang, Henggui, Benyhe, Sándor, Dézsi, L., Varró, András, Boyett, Marc, Vágvölgyi, C., Varró, A., Ötvös, F., Zhang, H., Papp, Gyula, Erdélyi, L., Erdélyi, Lajos   +23 more
core   +2 more sources

Routes for Potassium Ions across Mitochondrial Membranes: A Biophysical Point of View with Special Focus on the ATP-Sensitive K⁺ Channel

Biomolecules, 2021
Potassium ions can cross both the outer and inner mitochondrial membranes by means of multiple routes. A few potassium-permeable ion channels exist in the outer membrane, while in the inner membrane, a multitude of different potassium-selective and ...
Yevheniia Kravenska, Vanessa Checchetto, Ildiko Szabo   +2 more
doaj   +1 more source

Central cavity dehydration as a gating mechanism of potassium channels

Nature Communications, 2023
The hydrophobic gating model, in which ion permeation is inhibited by the hydrophobicity, rather than a physical occlusion of the nanopore, functions in various ion channels including potassium channels.
Ruo-Xu Gu, Bert L. de Groot
doaj   +1 more source

Kv7 and Kv11 channels in myometrial regulation. [PDF]

, 2013
Ion channels play a key role in defining myometrial contractility. Modulation of ion channel populations is proposed to underpin gestational changes in uterine contractility associated with the transition from uterine quiescence to active labour.
Tribe, Rachel M; id_orcid, Greenwood, IA, Rachel M. Tribe, Greenwood, Iain, Iain A. Greenwood, Tribe, RM   +5 more
core   +1 more source

Tandem pore TWIK-related potassium channels and neuroprotection

Neural Regeneration Research, 2019
TWIK-related potassium channels (TREK) belong to a subfamily of the two-pore domain potassium channels family with three members, TREK1, TREK2 and TWIK-related arachidonic acid-activated potassium channels.
J Antonio Lamas, Diego Fernández-Fernández   +1 more
doaj   +1 more source

Activation of TREK-1 and TREK-2 Two-Pore Domain Potassium Channels by the K_v4 Channel Modulator, NS5806. [PDF]

Pharmacol Res Perspect
NS5806 is a diaryl-urea small molecule developed for the treatment of pain and neurological disorders. A potent activator of Kv4.3 potassium channels, it is widely used to study Kv4 channel physiology in excitable cells, including trigeminal neurons ...
Veale EL, Matthews PM, Rush AM, Stevens EB, Mathie A.   +4 more
europepmc   +2 more sources

Pharmacological Approaches to Studying Potassium Channels

, 2021
In this review, we consider the pharmacology of potassium channels from the perspective of these channels as therapeutic targets. Firstly, we describe the three main families of potassium channels in humans and disease states where they are implicated ...
Alistair Mathie, Holden, Robyn G, Robyn G. Holden, Walsh, Yvonne, Emma L. Veale, Mathie, Alistair, Alessia Golluscio, Yvonne Walsh, Golluscio, Alessia, Veale, Emma L, Mathie, A., Holden, Robyn G., Veale, Emma L.   +12 more
core   +1 more source

Potassium Channelopathies and Gastrointestinal Ulceration

Gut and Liver, 2016
Potassium channels and transporters maintain potassium homeostasis and play significant roles in several different biological actions via potassium ion regulation.
Jaeyong Han, Seung Hun Lee, Gerhard Giebisch, Tong Wang   +3 more
doaj   +1 more source