Results 31 to 40 of about 401,972 (377)
Potassium channels in articular chondrocytes [PDF]
Channels, 2012 Chondrocytes are the resident cells of cartilage, which synthesize and maintain the extracellular matrix. The range of known potassium channels expressed by these unique cells is continually increasing. Since chondrocytes are non-excitable, and do not need to be repolarized following action potentials, the function of potassium channels in these cells ...
Mobasheri, A +5 more
openaire +4 more sources
A molecular target for viral killer toxin: TOK1 potassium channels. [PDF]
, 1999 Killer strains of S. cerevisiae harbor double-stranded RNA viruses and secrete protein toxins that kill virus-free cells. The K1 killer toxin acts on sensitive yeast cells to perturb potassium homeostasis and cause cell death. Here, the toxin is shown to
Ahmed, A +5 more
core +1 more source
Potassium Channels as a Potential Target Spot for Drugs [PDF]
, 2020 Aberrant function or expression of potassium channels can be underlying in pathologies such as cardiac arrhythmia, diabetes mellitus, hypertension, preterm birth, and various types of cancer.
Djokic, Vladimir, Novakovic, Radmila
core +1 more source
Potassium channels as tumour markers [PDF]
FEBS Letters, 2006 An increasing number of ion channels are being found to be causally involved in diseases, giving rise to the new field of “channelopathies”. Cancer is no exception, and several ion channels have been linked to tumour progression. Among them is the potassium channel EAG (Ether‐a‐go‐go).
Stuhmer, Walter +4 more
openaire +4 more sources
Tandem pore TWIK-related potassium channels and neuroprotection
Neural Regeneration Research, 2019 TWIK-related potassium channels (TREK) belong to a subfamily of the two-pore domain potassium channels family with three members, TREK1, TREK2 and TWIK-related arachidonic acid-activated potassium channels.
J Antonio Lamas +1 more
doaj +1 more source
Role of potassium channels in female reproductive system [PDF]
Obstetrics & Gynecology Science, 2020 Potassium channels are widely expressed in most types of cells in living organisms and regulate the functions of a variety of organs, including kidneys, neurons, cardiovascular organs, and pancreas among others. However, the functional roles of potassium
Jun-Mo Kim +3 more
doaj +1 more source
Potassium Channels: Complete and Undistorted [PDF]
Current Biology, 2005 The recently determined structure of a mammalian voltage-gated potassium channel has important implications for our understanding of voltage-sensing and gating mechanisms in channels. It is also the first crystal structure of an overexpressed eukaryotic membrane protein.
Grottesi, A, Sands, Z, Sansom, MS
openaire +3 more sources
Potassium Channelopathies and Gastrointestinal Ulceration
Gut and Liver, 2016 Potassium channels and transporters maintain potassium homeostasis and play significant roles in several different biological actions via potassium ion regulation.
Jaeyong Han +3 more
doaj +1 more source
Investigating the Selectivity of KcsA Channel by an Image Charge Solvation Method (ICSM) in Molecular Dynamics Simulations [PDF]
, 2015 In this paper, we study the selectivity of the potassium channel KcsA by a recently developed image-charge solvation method(ICSM) combined with molecular dynamics simulations. The hybrid solvation model in the ICSM is able to demonstrate atomistically the function of the selectivity filter of the KcsA channel when potassium and sodium ions are ...
arxiv +1 more source
The persistent question of potassium channel permeation mechanisms [PDF]
arXiv, 2021 Potassium channels play critical roles in many physiological processes, providing a selective permeation route for K+ ions in and out of a cell, by employing a carefully designed selectivity filter, evolutionarily conserved from viruses to mammals. The structure of the selectivity filter was determined at atomic resolution by x-ray crystallography ...
arxiv