Lack of direct evidence for a functional role of voltage-operated calcium channels in juxtaglomerular cells [PDF]
, 1990 In this study we have examined the role of voltage-gated calcium channels in the regulation of calcium in juxtaglomerular cells. Using a combination of patch-clamp and single-cell calcium measurement we obtained evidence neither for voltage-operated ...
Chegini, S. +3 more
core +1 more source
A functional role for small-conductance calcium-activated potassium channels in sensory pathways including nociceptive processes [PDF]
, 2005 We investigated the role of small-conductance calcium-activated potassium (SK) and intermediate-conductance calcium-activated potassium channels in modulating sensory transmission from peripheral afferents into the rat spinal cord.
Bahia, PK +7 more
core +1 more source
Tandem pore TWIK-related potassium channels and neuroprotection
Neural Regeneration Research, 2019 TWIK-related potassium channels (TREK) belong to a subfamily of the two-pore domain potassium channels family with three members, TREK1, TREK2 and TWIK-related arachidonic acid-activated potassium channels.
J Antonio Lamas +1 more
doaj +1 more source
Fast inactivation in Shaker K+ channels. Properties of ionic and gating currents. [PDF]
, 1998 Fast inactivating Shaker H4 potassium channels and nonconducting pore mutant Shaker H4 W434F channels have been used to correlate the installation and recovery of the fast inactivation of ionic current with changes in the kinetics of gating current known
Bezanilla, F +4 more
core +3 more sources
The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line. [PDF]
, 2011 The voltage gated potassium (K+) channels Eag and HERG have been implicated in the pathogenesis of various cancers, through association with cell cycle changes and programmed cell death.
Anish Bali +6 more
core +5 more sources
The therapeutic agents that target ATP-sensitive potassium channels
Acta Pharmaceutica, 2016 ATP-sensitive potassium (KATP) channels are a major drug target for the treatment of type-2 diabetes. KATP channels are ubiquitously expressed and link the metabolic state to electrical excitability.
Hussein N. Rubaiy
semanticscholar +1 more source
Potassium Channels and Human Epileptic Phenotypes: An Updated Overview
Frontiers in Cellular Neuroscience, 2016 Potassium (K+) channels are expressed in almost every cells and are ubiquitous in neuronal and glial cell membranes. These channels have been implicated in different disorders, in particular in epilepsy.
C. Villa, R. Combi
semanticscholar +1 more source
Potassium Channelopathies and Gastrointestinal Ulceration
Gut and Liver, 2016 Potassium channels and transporters maintain potassium homeostasis and play significant roles in several different biological actions via potassium ion regulation.
Jaeyong Han +3 more
doaj +1 more source
The conduction pathway of potassium channels is water free under physiological conditions. [PDF]
, 2019 Ion conduction through potassium channels is a fundamental process of life. On the basis of crystallographic data, it was originally proposed that potassium ions and water molecules are transported through the selectivity filter in an alternating ...
Chevelkov, V. +9 more
core +1 more source
Data in Brief, 2021 In the present work, applying the whole-cell patch-clamp technique in voltage clamp mode, we have investigated the effects of different drugs, such as riluzole, Psora-4 and Tram-34, on the potassium currents in four human lymphoma cell lines.
Alberto Montalbano +8 more
doaj +1 more source