Results 91 to 100 of about 1,453,821 (301)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Pure Powers Are Not Powerful Qualities
European Journal of Analytic Philosophy, 2021 There is no consensus on the most adequate conception of the fundamental properties of our world. The pure powers view and the identity theory of powerful qualities claim to be promising alternatives to categoricalism, the view that all fundamental properties essentially contribute to the qualitative make-up of things that have them.
openaire +3 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
, 2013 Publisher Copyright: © 2013, European Association for the Development of Renewable Energy, Environment and Power Quality (EA4EPQ). All rights reserved.In rural distribution networks with widely dispersed loads, characterized by the utilization of long ...
M.A. Rodriguez +7 more
core +1 more source
EnergiesAiming at the problems of low equipment utilization and the high-capacity requirements of existing arc-suppression devices, a multi-functional reactive power compensation device with the capability of grounding fault regulation (MF-RPCD) is proposed ...
Zejun Huang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Global sensitivity and uncertainty analysis of transients in the Universal Line Model
, 2014 One of the main aspects of designing and operation prediction of any power system is to simulate its Electromagnetic Transient's (EMT) performance. Among the available power line models, Universal Line Model (ULM) is an efficient and accurate model for ...
Shahabi Ghahfarokhi, N. +3 more
core +1 more source
Quantifying the Economic Impact of Supply Voltage Magnitude on Consumers
EnergiesIncreasing penetration of distributed energy resources is manifesting as voltage regulation challenges in many LV networks. Appropriate regulation of supply voltage magnitude is essential to ensure efficacy and efficiency in the operation of electricity ...
Sean Elphick +4 more
doaj +1 more source
, 2011 Electrical power is becoming one of the most dominant factors in our society. Power generation, transmission, distribution and usage are undergoing signifi cant changes that will aff ect the electrical quality and performance needs of our 21st century industry.
openaire +3 more sources