Results 91 to 100 of about 5,629,230 (293)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Evaluation of Power Quality in Off-Grid Power System
Communications, 2015 The energy independence, reliability and safety of energy distribution system operation as well as use of renewable resources have been hot research topics in recent years. This research leads to the development of active distribution grids with specific
Stanislav Misak +3 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Upholding the Dignity and Best Interest of Children: International Law and the Corporal Punishment of Children [PDF]
, 1999 When the systems evolved from analog to digital, the performance was improved by the use of power control on the one hand and different modulations and coding schemes on the other. Condensing the available information we are able to propose a new concept
Blom, Jonas +2 more
core +1 more source
, 2013 We have studied the surface quality of millimeter-scale optical mirrors produced by etching CZ and FZ silicon wafers in potassium hydroxide to expose the $\{111\}$ planes.
Cotter, J. P. +3 more
core +1 more source
EnergiesAiming at the problems of low equipment utilization and the high-capacity requirements of existing arc-suppression devices, a multi-functional reactive power compensation device with the capability of grounding fault regulation (MF-RPCD) is proposed ...
Zejun Huang +5 more
doaj +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Quantifying the Economic Impact of Supply Voltage Magnitude on Consumers
EnergiesIncreasing penetration of distributed energy resources is manifesting as voltage regulation challenges in many LV networks. Appropriate regulation of supply voltage magnitude is essential to ensure efficacy and efficiency in the operation of electricity ...
Sean Elphick +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source