Results 51 to 60 of about 14,236 (163)
ChemMedChem, Volume 20, Issue 23, November 28, 2025.From structure prediction to inhibition, AlphaFold‐Multimer pinpoints a Miz‐1/MAX interaction overlap on MYC, enabling the creation of peptidomimetics that shut down MYC/MAX/DNA binding with submicromolar potency. Intrinsically disordered proteins (IDPs) lack stable structure and classical binding pockets, making them remarkably difficult to drug ...
Brecht D. Ellenbroek +2 more
wiley +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, Volume 599, Issue 21, Page 3012-3028, November 2025.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Advanced Science, Volume 12, Issue 42, November 13, 2025.Current herpesvirus treatments targeting the viral DNA polymerase are limited by toxicities and drug resistance. Novel compounds inhibiting the nuclease activity of the herpes simplex virus 1 (HSV‐1) terminase complex, required for viral genome packaging, have been identified.
Sabina Andreu +12 more
wiley +1 more source
Bisbenzimide compounds inhibit the replication of prototype and pandemic potential poxviruses
Microbiology SpectrumWe previously identified the bisbenzimide Hoechst 33342 (H42) as a potent multi-stage inhibitor of the prototypic poxvirus, the vaccinia virus (VACV), and several parapoxviruses.
Jerzy Samolej +8 more
doaj +1 more source
Genome of Alaskapox Virus, a Novel Orthopoxvirus Isolated from Alaska
Viruses, 2019 Since the eradication of smallpox, there have been increases in poxvirus infections and the emergence of several novel poxviruses that can infect humans and domestic animals. In 2015, a novel poxvirus was isolated from a resident of Alaska.
Crystal M. Gigante +9 more
doaj +1 more source
Breaking barriers: The cGAS‐STING pathway as a novel frontier in cancer immunotherapy
Cancer Communications, Volume 45, Issue 11, Page 1513-1546, November 2025.Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan +5 more
wiley +1 more source
Ecography, Volume 2025, Issue 11, November 2025.Hawaii has experienced profound declines in native avifauna alongside the introduction of numerous bird species. While site‐specific population studies are common, landscape‐level analyses of avian population dynamics are rare, particularly in island ecosystems. To address this gap, we used a density surface model to create a spatio‐temporal projection
Trevor Bak +5 more
wiley +1 more source
Changes in HIV‐1 Reservoir Dynamics After Mpox Infection
Journal of Medical Virology, Volume 97, Issue 11, November 2025.ABSTRACT In May 2022, a large outbreak of monkeypox virus (MPXV) occurred in several non‐endemic regions worldwide. Another outbreak in 2024 raised global concerns, particularly for immunocompromised individuals like people with HIV (PWH). Since the latent HIV‐1 reservoir remains a major barrier to a cure, we investigated how past mpox infection ...
Guiomar Casado‐Fernández +14 more
wiley +1 more source
Pixelated pathologies: Camera trapping as a tool for monitoring wildlife health
Journal of Applied Ecology, Volume 62, Issue 11, Page 2894-2913, November 2025.Given the increasing emergence of diseases, some with conservation and public health implications, improving and expanding wildlife health surveillance strategies is imperative. Camera trapping is particularly relevant for detecting new outbreaks, monitoring high‐risk zones and evaluating risk mitigation measures. Abstract Camera trapping has become an
Patricia Barroso, Pablo Palencia
wiley +1 more source