Results 11 to 20 of about 14,001 (196)
Research Review on Inhibitors of Lumpy Skin Disease Virus: From Biological Characteristics, Drug Repurposing, to Computer-Aided Drug Design. [PDF]
Int J MicrobiolThis review summarizes the research progress on inhibitors of lumpy skin disease virus (LSDV), focusing on its biological characteristics and key proteins involved in the viral replication cycle. It compiles various inhibitors (direct‐acting poxvirus inhibitors and host‐directed poxvirus inhibitors) against poxviruses, their mechanisms of action, and ...
Zhao L +6 more
europepmc +2 more sources
Vaccines, 2023 Background: The years 2022–2023 witnessed a monkeypox virus (mpox) outbreak in some countries worldwide, where it exists in an endemic form. However, the number of infectious cases is continuously on the rise, and there has been an unexpected, drastic ...
Shiza Malik +4 more
doaj +1 more source
Poxviruses Aren't StuPYD [PDF]
Immunity, 2005 Pathogens utilize many strategies to dampen the host inflammatory response. In this issue of Immunity, a report by Johnston and colleagues reveals a poxvirus strategy that inhibits the inflammasome, arresting secretion of interleukin-1-related cytokines, thus silencing key alarms that mobilize host defenses.
Benedict, Chris A., Ware, Carl F.
openaire +2 more sources
Poxvirus Interactions with the Host Ubiquitin System
Pathogens, 2021 The ubiquitin system has emerged as a master regulator of many, if not all, cellular functions. With its large repertoire of conjugating and ligating enzymes, the ubiquitin system holds a unique mechanism to provide selectivity and specificity in ...
Sian Lant, Carlos Maluquer de Motes
doaj +1 more source
Veterinary Microbiology, 2010 (Uploaded by Plazi for the Bat Literature Project) Poxviruses compromise a group of long known important pathogens including some zoonotic members affecting lifestock animals and humans. While whole genome sequence analysis started to shed light into the molecular mechanisms underlying host cell infection, viral replication as well as virulence, our ...
Essbauer, Sandra +2 more
openaire +3 more sources
Poxviral ANKR/F-box Proteins: Substrate Adapters for Ubiquitylation and More
Pathogens, 2022 Poxviruses are double-stranded DNA viruses that infect insects and a variety of vertebrate species. The large genomes of poxviruses contain numerous genes that allow these viruses to successfully establish infection, including those that help evade the ...
Robert J. Ingham +2 more
doaj +1 more source
In Silico Repurposed Drugs against Monkeypox Virus
Molecules, 2022 Monkeypox is an emerging epidemic of concern. The disease is caused by the monkeypox virus and an increasing global incidence with a 2022 outbreak that has spread to Europe amid the COVID-19 pandemic. The new outbreak is associated with novel, previously
Hilbert Yuen In Lam +2 more
doaj +1 more source
Una nueva alerta mundial en salud causada por la viruela del simio
Interdisciplinary Journal of Epidemiology and Public Health, 2022 Introducción: La viruela del simio es una zoonosis de etiología viral causada por virus de la viruela del simio. Es una enfermedad endémica en los países africanos.
Richar Jose Gomez de la Rosa +1 more
doaj +1 more source
Viruses, 2021 Mass vaccination has played a critical role in the global eradication of smallpox. Various vaccinia virus (VACV) strains, whose origin has not been clearly documented in most cases, have been used as live vaccines in different countries.
Sergei N. Shchelkunov +11 more
doaj +1 more source
From actually toxic to highly specific – novel drugs against poxviruses [PDF]
, 2007 The potential use of variola virus, the causative agent of smallpox, as a bioweapon and the endemic presence of monkeypox virus in Africa demonstrate the need for better therapies for orthopoxvirus infections. Chemotherapeutic approaches to control viral
Sliva, Katja, Schnierle, Barbara
core +2 more sources