Results 41 to 50 of about 14,001 (196)

Addressing poxvirus challenges in the Middle East to enhance biosafety and biosecurity measures

Journal of Biosafety and Biosecurity
The emergence and zoonotic transmission of poxviruses in the Middle East have been recognized as complex public health issues. Poxviruses, a vast family of DNA viruses, can infect many hosts, including animals and humans. The Middle East has had multiple
Laith N. AL-Eitan, Haneen O. Ali, Hana S. Abu Kharmah, Maryam K. Alasmar, Iliya Y. Khair, Ahmad H. Mihyar   +5 more
doaj   +1 more source

Decoding poxvirus genome [PDF]

, 2015
Citation: Yang, Z. L., & Moss, B. (2015). Decoding poxvirus genome. Oncotarget, 6(30), 28513-28514. doi:10.18632/oncotarget.5892Deciphering the information encoded in genomic sequences is a key step in modern biomedical research. Recent findings indicate
Moss, B., Yang, Zhilong L.
core   +2 more sources

Formulation of next-generation polyvalent vaccine candidates against three important poxviruses by targeting DNA-dependent RNA polymerase using an integrated immunoinformatics and molecular modeling approach

Journal of Infection and Public Health
Background: Poxviruses comprise a group of large double-stranded DNA viruses and are known to cause diseases in humans, livestock animals, and other animal species. The Mpox virus (MPXV; formerly Monkeypox), variola virus (VARV), and volepox virus (VPXV)
Anuj Kumar, Mansi Dutt, Budheswar Dehury, Gustavo Sganzerla Martinez, Krishna Pal Singh, David J. Kelvin   +5 more
doaj   +1 more source

Suppression of Poxvirus Replication by Resveratrol

Frontiers in Microbiology, 2017
Poxviruses continue to cause serious diseases even after eradication of the historically deadly infectious human disease, smallpox. Poxviruses are currently being developed as vaccine vectors and cancer therapeutic agents.
Shuai Cao, Susan Realegeno, Anil Pant, Panayampalli S. Satheshkumar, Zhilong Yang   +4 more
doaj   +1 more source

Contemporary outbreaks of different avipoxviruses in Humboldt penguins of wild animal park Planckendael and in chickens of commercial poultry farms in Belgium [PDF]

, 2017
In the present study, the first outbreak of a penguinpox virus (PPV) in Humboldt penguins (Spheniscus humboldd) and four outbreaks of fowlpox virus (FPV) in layer chickens are reported.
Avalakuppa Papi Reddy, Vishwanatha Reddy, Nauwynck, Hans, Trus, Ivan, Vercammen, Francis   +3 more
core  

Viruses and the cellular RNA decay machinery. [PDF]

, 2010
The ability to control cellular and viral gene expression, either globally or selectively, is central to a successful viral infection, and it is also crucial for the host to respond and eradicate pathogens.
Gaglia, Marta, Glaunsinger, Britt
core   +1 more source

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, EarlyView.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source

Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors. [PDF]

, 2009
Protein kinase PKR (also known as EIF2AK2) is activated during viral infection and phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF2), leading to inhibition of translation and viral replication. We report fast evolution
Dever, Thomas E, Dittmar, Katharina, Gibbs, James S, Rothenburg, Stefan, Seo, Eun Joo   +4 more
core  

Using purine skews to predict genes in AT-rich poxviruses [PDF]

, 2005
BioMed CentralBackground: Clusters or runs of purines on the mRNA synonymous strand have been found in many different organisms including orthopoxviruses.
Da Silva, Melissa, Upton, Chris
core   +1 more source

Identification of genetically predicted protein biomarkers and drug targets for prostate cancer via Mendelian randomization

VIEW, EarlyView.
Prostate cancer, a leading cause of cancer in men globally, urgently requires improved diagnostic and treatment strategies. This study analyzed large genetic datasets and identified five key proteins (THBD, DST, IFI27L2, OSBPL10, PPP1R14A) that either increase or decrease cancer risk, while also exploring their roles in immune response and potential ...
Maoping Cai, Tianming Peng, Zhiyue Xie, Chuqian Zhen, Chen Yao, Nan Peng, Qianyi Li, Yuzhong Yu, Jiming Bao, Xian‐Lu Song, Mingkun Chen, Shan‐Chao Zhao   +11 more
wiley   +1 more source