Results 61 to 70 of about 14,853 (241)
Clinical Trials of Immunogene Therapy for Spontaneous Tumors in Companion Animals [PDF]
, 2014 Despite the important progress obtained in the treatment of some pets’ malignancies, new treatments need to be developed. Being critical in cancer control and progression, the immune system’s appropriate modulation may provide effective therapeutic ...
Finocchiaro, Liliana Maria Elena +1 more
core +4 more sources
Lipid nanoparticle delivery of unmodified mRNAs encoding multiple monoclonal antibodies targeting poxviruses in rabbits [PDF]
, 2022 Eric M. Mucker +3 more
openalex +1 more source
MedComm, Volume 7, Issue 2, February 2026.We developed four candidate mRNA vaccine antigens based on conserved sequences of MPXV A35R and M1R proteins. Our findings demonstrate that the MV2 vaccine possesses favorable immunogenicity and prophylactic potential against MPXV and VACV infections, positioning it as a promising clinical candidate for MPXV prevention.
Cong Tang +14 more
wiley +1 more source
Immune modulation by virus-encoded secreted chemokine binding proteins [PDF]
, 2015 Chemokines are chemoattractant cytokines that mediate the migration of immune cells to sites of infection which play an important role in innate and adaptive immunity. As an immune evasion strategy, large DNA viruses (herpesviruses and poxviruses) encode
Alcamí, Antonio +2 more
core +1 more source
Cell Host & Microbe, 2007 Successful viruses engage in a dynamic interplay with their hosts, where both utilize diverse strategies to impose their supremacy. In this issue of Cell Host & Microbe, Wiebe and Traktman describe a novel interaction between vaccinia virus and mammalian cells.
Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida Southwest Archer Road, P.O. Box 100332, Gainesville, FL 32610, USA ( host institution ) +2 more
openaire +3 more sources
Mathematical Modeling of the Role of Cytokines in Sindbis Virus Treatment of Glioblastoma
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.ABSTRACT Oncolytic viruses, specifically Sindbis virus (SINV), combined with cytokines show promising results in slowing glioma progression, but a quantitative understanding of their effects remains limited. In this study, we use an ordinary differential equation (ODE) model to examine the effect of adding cytokines to oncolytic SINV therapy.
Shriya Makam, Hana M. Dobrovolny
wiley +1 more source
The Origin and Evolution of Viruses as Molecular Organisms [PDF]
, 2009 Viruses are the most abundant life forms and the repertoire of viral genes is greater than that of cellular genes. It is also evident that viruses have played a major role in driving cellular evolution, and yet, viruses are not part of mainstream biology,
Claudiu I. Bandea
core +2 more sources
Impact of distinct poxvirus infections on the specificities and functionalities of CD4+ T cell responses. [PDF]
, 2014 UNLABELLED: The factors that determine CD4+ T cell (TCD4+) specificities, functional capacity, and memory persistence in response to complex pathogens remain unclear.
A. M. Lacuanan +120 more
core +2 more sources
Journal of Medical Virology, Volume 98, Issue 1, January 2026.ABSTRACT Dengue poses a significant arboviral threat in Brazil, with 2024 recording the largest outbreak to date. This prospective observational study was conducted during the 2024 outbreak with unvaccinated patients at Eduardo de Menezes Hospital, Belo Horizonte.
Samille Henriques Pereira +13 more
wiley +1 more source
Expression of Sindbis virus structural proteins via recombinant vaccinia virus: synthesis, processing, and incorporation into mature Sindbis virions [PDF]
, 1985 We have obtained a vaccinia virus recombinant which contains a complete cDNA copy of the 26S RNA of Sindbis virus within the thymidine kinase gene of the vaccinia virus genome.
Franke, Christine A. +3 more
core