Results 81 to 90 of about 14,853 (241)

Current understanding of lymphoproliferative disease virus in wild turkeys

Wildlife Society Bulletin, Volume 49, Issue S1, December 2025.
Lymphoproliferative disease virus (LPDV) is a retrovirus that can cause a spectrum of disease in wild turkeys (Meleagris gallopavo), from subclinical infection to lymphoid tumors. We reviewed the literature to summarize our current understanding of LPDV, including disease presentation, surveillance, impact on fitness, spatiotemporal distribution, and ...
Chloe C. Goodwin, Andrew B. Allison, Mark G. Ruder, Justin D. Brown, Michael J. Chamberlain, Melanie R. Kunkel, Kevin D. Niedringhaus, Alisia A. W. Weyna, Charlie S. Bahnson, Elizabeth L. Elsmo, M. Kevin Keel, Heather Fenton, Kayla G. Adcock, Rebecca L. Poulson, Nicole M. Nemeth   +14 more
wiley   +1 more source

Recombinant viruses as tools to induce protective cellular immunity against infectious diseases [PDF]

, 2010
Infections by intracellular pathogens such as viruses, some bacteria and many parasites, are cleared in most cases after activation of specific T cellular immune responses that recognize foreign antigens and eliminate infected cells.
Alexandre Vieira Machado, Braulia Costa Caetano, Carolina Damas Rocha, Oscar Bruña-Romero   +3 more
core   +2 more sources

AlphaFold‐Guided Discovery of an Overlapping MYC/Miz‐1 Interface Enables Peptidomimetic Disruption of MYC/MAX

ChemMedChem, Volume 20, Issue 23, November 28, 2025.
From structure prediction to inhibition, AlphaFold‐Multimer pinpoints a Miz‐1/MAX interaction overlap on MYC, enabling the creation of peptidomimetics that shut down MYC/MAX/DNA binding with submicromolar potency. Intrinsically disordered proteins (IDPs) lack stable structure and classical binding pockets, making them remarkably difficult to drug ...
Brecht D. Ellenbroek, Amardhiko S. S. Tirtosentono, Sebastian J. Pomplun   +2 more
wiley   +1 more source

Tanapox Virus and Yaba Monkey Tumor Virus K3 Orthologs Inhibit Primate Protein Kinase R in a Species-Specific Fashion

Viruses
Yaba monkey tumor virus (YMTV) and Tanapox virus (TPV) are members of the Yatapoxvirus genus and can infect humans and other primates. Despite the threat posed by yatapoxviruses, the factors determining their host range are poorly understood.
Dewi Megawati, Jeannine N. Stroup, Chorong Park, Taylor Clarkson, Loubna Tazi, Greg Brennan, Stefan Rothenburg   +6 more
doaj   +1 more source

A paralogous pair of mammalian host restriction factors form a critical host barrier against poxvirus infection. [PDF]

PLoS Pathogens, 2018
Host restriction factors constitute a formidable barrier for viral replication to which many viruses have evolved counter-measures. Human SAMD9, a tumor suppressor and a restriction factor for poxviruses in cell lines, is antagonized by two classes of ...
Xiangzhi Meng, Fushun Zhang, Bo Yan, Chuanping Si, Hiroaki Honda, Akiko Nagamachi, Lu-Zhe Sun, Yan Xiang   +7 more
doaj   +1 more source

First molecular detection and characterization of herpesvirus and poxvirus in a Pacific walrus (Odobenus rosmarus divergens) [PDF]

, 2014
BACKGROUND Herpesvirus and poxvirus can infect a wide range of species: herpesvirus genetic material has been detected and amplified in five species of the superfamily Pinnipedia; poxvirus genetic material, in eight species of Pinnipedia.
Corpa, Juan Manuel, Crespo, José Luis, García Párraga, Daniel, Melero Asensio, Mar, Ortega, Joaquín, Rivera Arroyo, Belén, Rubio Guerri, Consuelo, Sánchez-Vizcaíno, José Manuel   +7 more
core   +2 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, Volume 599, Issue 21, Page 3012-3028, November 2025.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

TESTING SHEEP AND GOAT POX VIRUSES FOR THEIR REPRODUCTION IN PRIMARY AND SUBCULTURED CELLS

Ветеринария сегодня, 2019
Results of tests of sheep and goat poxviruses for their reproduction in primary and subcultured cell cultures derived from lamb and goat kid kidneys and testicles are presented.
A. B. Sarbasov, B. L. Manin, R. V. Yashin, I. N. Shumilova, V. I. Diev   +4 more
doaj   +1 more source

Experimental infections of different carp strains with the carp edema virus (CEV) give insights into the infection biology of the virus and indicate possible solutions to problems caused by koi sleepy disease (KSD) in carp aquaculture [PDF]

, 2017
Outbreaks of koi sleepy disease (KSD) caused by carp edema virus (CEV) may seriously affect populations of farmed common carp, one of the most important fish species for global food production. The present study shows further evidence for the involvement
Adamek, Jerzy, Adamek, Mikolaj, Bergmann, Sven M., Dawson, Andy, Gela, David, Jung-Schroers, Verena, Kocour, Martin, Oschilewski, Anna, Piackova, Veronika, Steinhagen, Dieter, Teitge, Felix, Wohlsein, Peter   +11 more
core   +4 more sources

Discovery of a Baloxavir‐Inspired Endonuclease Inhibitor That Prevents Herpes Simplex Virus 1 Replication in Cell Culture and In Vivo

Advanced Science, Volume 12, Issue 42, November 13, 2025.
Current herpesvirus treatments targeting the viral DNA polymerase are limited by toxicities and drug resistance. Novel compounds inhibiting the nuclease activity of the herpes simplex virus 1 (HSV‐1) terminase complex, required for viral genome packaging, have been identified.
Sabina Andreu, Kai Tang, Jiahui Zhou, Gabriel Pino‐Peco, Nerea López‐Carrobles, Raquel Bello‐Morales, Daniel Galdo‐Torres, Lina Zhang, Federico Gago, José Antonio López‐Guerrero, Xinyong Liu, Peng Zhan, Luis Menéndez‐Arias   +12 more
wiley   +1 more source