Results 171 to 180 of about 121,549 (307)

Macrophage-specific PPARγ controls alternative activation and improves insulin resistance

Nature, 2007
J. Odegaard, R. Ricardo-Gonzalez, Matthew H. Goforth, Christine R. Morel, V. Subramanian, Lata Mukundan, A. Eagle, Divya Vats, F. Brombacher, A. Ferrante, A. Chawla   +10 more
semanticscholar   +1 more source

Exercise serum promotes DNA damage repair and remodels gene expression in colon cancer cells

International Journal of Cancer, EarlyView.
What's New? Exercise releases bioactive molecules into the bloodstream that can directly slow cancer cell growth. In colon cancer, this may help limit disease progression. Here, using colon cancer cells, the authors investigated the effects of exercise‐conditioned human serum on DNA repair mechanisms. Notably, acute exercise in humans elicited systemic
Samuel T. Orange, Emily Dodd, Sharanya Nath, Hannah Bowden, Alastair R. Jordan, Hannah Tweddle, Ann Hedley, Ifeoma Chukwuma, Ian Hickson, Sweta Sharma Saha   +9 more
wiley   +1 more source

Oleoylethanolamide regulates intestinal stem cell activity and villus size via PPARα signaling pathway

iMetaOmics, EarlyView.
First use of a natural swine model with lipid metabolism to directly link lipid differences to a quantifiable intestinal villus height phenotype. Identified the phospholipid‐derived oleoylethanolamide, rather than canonical fatty acids, as the endogenous primary ligand that activates peroxisome proliferator‐activated receptors α (PPARα) to enlarge ...
Qianqian Wang, Lanmei Yin, Zhaobin Wang, Jun Li, Xianglin Zeng, Qiye Wang, Jianzhong Li, Kang Xu, Huansheng Yang, Yulong Yin   +9 more
wiley   +1 more source

Climate factors drive the local adaptation of Old World cattle

iMeta, EarlyView.
Climate adaptation genomics of cattle. We comparatively analyzed genomic data from 85 Old World cattle breeds/populations of Eurasia and Africa to identify genetic factors associated with climate factors. Environmental genome‐wide association studies revealed 3165 single‐nucleotide polymorphisms (SNPs) with strong correlations between climate factors ...
Luyang Sun, Liangliang Jin, Ting Sun, Chenqi Bian, Fuwen Wang, Shuang Li, Hao Li, Jianyong Liu, Jicai Zhang, Johannes A. Lenstra, Artem Nedoluzhko, Zhuqing Zheng, Ruidong Xiang, Wai Yee Low, Wangdui Basang, Zhuzha Basang, Bin Li, Quji Suolang, Li Zhao, Wangmu Silang, Luobu Ciren, Zhandui Pubu, Qiangma Xire, Yanliang Song, Yuanpeng Gao, Dawei Wei, Rende Song, Min‐Sheng Peng, Bizhi Huang, Yun Ma, Xiaoting Xia, Chuzhao Lei, Ningbo Chen   +32 more
wiley   +1 more source

Myosin 1b Inhibits the Phenotype of HemECs to Affect the Progression of Infantile Hemangiomas

Clinical, Cosmetic and Investigational Dermatology
Nanxi Li, Xiangan Gong, Zhongying Cao, Zhiyu Li, Luying Wang, Ran Huo,* Cong Fu* Department of Plastic and Aesthetic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People’s Republic of China&ast ...
Li N, Gong X, Cao Z, Li Z, Wang L, Huo R, Fu C   +6 more
doaj  

Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue

iNew Medicine, EarlyView.
ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao, Jingjing Sun, Yan Lu, Ying Yang   +3 more
wiley   +1 more source

Sequential ultrasound‐driven dynamic control of macrophage polarization combined with hydrogel for mechano‐chemical synergistic tissue repair

Interdisciplinary Medicine, EarlyView.
This study presents an innovative therapeutic strategy that integrates sequential ultrasound therapy with an injectable oxidized dextran‐metformin (ODE‐Met) hydrogel to dynamically regulate macrophage polarization and promote angiogenesis for inflamed tissue repair.
Fulong Man, Kun Wang, Zichen Yang, Lulu An, Caoyi You, Rongjie Li, Yanni Cai, Yang Li, Li Chen, Yiqiong Liu, Yan Li, Haiqing Dong, Yongyong Li   +12 more
wiley   +1 more source

Evaluating the Endocrine‐Disrupting and Oxidative Stress Potential of a 50‐Component Human‐Relevant Complex Chemical Mixture Using In Vitro Tests

Journal of Applied Toxicology, EarlyView.
ABSTRACT Humans are chronically exposed to mixtures of environmental contaminants. Exposure to endocrine‐disrupting chemicals (EDCs) contributes to increased health impairment observed globally. This study aimed to evaluate the endocrine‐disruptive and oxidative stress potential of a human‐relevant, complex chemical mixture in vitro.
Josefin Engelhardt, Nathalie Struwe, Annika Jansson, Vesna Munic Kos, Maria Larsson, Jana M. Weiss   +5 more
wiley   +1 more source

Mesenchymal Stem Cell‐Mediated Vascular Regeneration in Diabetic Foot Ulcers via the Notch Signaling Pathway

Journal of Clinical Laboratory Analysis, EarlyView.
This graphical abstract illustrates the experimental design and key findings of the study on the role of mesenchymal stem cells (MSCs) and Notch signaling in diabetic foot ulcer (DFU) healing. The study involved five groups of BALB/c mice: Control, Model, MSCs Treatment, MSCs + Notch Inhibition, and MSCs + Notch Activation.
Feifei Li, Li Xu, Xin Hou, Dengfeng Zhu, Jingming Ou, Zuwei Yang, Yuhong Gu   +6 more
wiley   +1 more source

Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ

Cell, 1998
L. Nagy, P. Tontonoz, J. G. Alvarez, Hongwu Chen, R. Evans   +4 more
semanticscholar   +1 more source