Results 181 to 190 of about 66,281 (214)

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Semaglutide and pioglitazone restore airway mucosal homeostasis by resolving <i>Pseudomonas aeruginosa</i> pyocyanin-induced mucus hypersecretion, ciliostasis, and type 2 airway inflammation. [PDF]

Front Immunol
Wu C, Kulkarni NA, Lew SQ, Choi W, Sivaguru M, Kosmider B, Nanjappa SG, Lau GW.   +7 more
europepmc   +1 more source

Association of altered body composition with cardiac wasting in cancer with and without cardiotoxic therapy

British Journal of Pharmacology, EarlyView.
Created in BioRender: Scientific Figure and Illustration Software. Background and Purpose In advanced cancer, associations among changes in body composition, cardiac wasting and prior cardiotoxic anticancer therapy have not been investigated. Experimental Approach Using bioelectrical impedance analysis (BIA), body composition was measured in 206 ...
Sara Hadzibegovic, Jonathan L. Hella, Jan Porthun, Alessia Lena, Danara Krug, Iulia Baluta, Ursula Wilkenshoff, Amir A. Mahabadi, Matthias Totzeck, Tienush Rassaf, Stefan D. Anker, Wolfram Doehner, Ulrich Keller, Lars Bullinger, Dominik P. Modest, Barry J. A. Laird, Richard J. E. Skipworth, John G. F. Cleland, Christian Oeing, Stephan von Haehling, Ulf Landmesser, Markus S. Anker   +21 more
wiley   +1 more source

Multiple binding modes underlie <i>Cannabis sativa</i> cannabinoids recognition by peroxisome proliferator-activated receptor gamma. [PDF]

Front Bioinform
Alves NRC, Miranda J, Alvarez LD.
europepmc   +1 more source

Inhibition of the NR4A1‐mediated cell cycle checkpoint enhances hyperplastic adipogenesis and glucose homeostasis in obesity

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The nuclear receptor NR4A1 is a critical node in transcriptional circuits for metabolic adaptation, yet its role in adipocyte progenitor (AP) fate and proliferation is unclear. We sought to define how NR4A1 governs early adipogenesis and adipose tissue plasticity.
Wanning Qiao, Cun Ku, G. V. Naveen Kumar, Jonathan D. Brown, Manni Wu, Chenhang Li, Jiyu Xie, Huicui Meng, Litao Sun, Tao Zhou, Dong Liang, Yiwei Li, Matthew L. Steinhauser, Yang Zhang   +13 more
wiley   +1 more source

Dietary melatonin and its benefits on cardiovascular disease

British Journal of Pharmacology, EarlyView.
Cardiovascular disease remains the leading cause of mortality globally, with a disproportionate burden in low‐ and middle‐income countries. Melatonin, a hormone primarily produced by the pineal gland, exhibits notable antioxidant, anti‐inflammatory and immunomodulatory properties that may confer cardiovascular benefits.
Karabo Tisane, Carmelita Abrahams, Sandrine Lecour   +2 more
wiley   +1 more source

Arginase 2 deficiency mitigates sepsis-associated acute kidney injury by alleviating lipid accumulation. [PDF]

Clin Transl Med
Xin Y, Liu Y, Zhang N, Huang P, Zhang Q, Luo Y, Wang X, Zhang X, Wu T, Liu F, Xiao Y, Shen L, Zhang W, Wang X, Meng X, Bai Y, Wang X, Zhang N, Xu Q, Meng H, Zheng X, Cheng L, Yu K, Wang C.   +23 more
europepmc   +1 more source

Neurotoxicity of Synthetic Cannabinoid Receptor Agonist Cumyl-PINACA: An In Vitro Study on Rat Cortical Neurons and Astrocytes. [PDF]

Pharmaceuticals (Basel)
Jurič DM, Bulc Rozman K, Lipnik-Štangelj M, Šuput D, Brvar M.   +4 more
europepmc   +1 more source

scRNA‐Seq in Gastric Cancer Reveals Macrophage‐Derived C1q as a Diagnostic Marker

Cancer Science, EarlyView.
Single‐cell sequencing of GC analyzed the tumor microenvironment and discovered the C1QA+ TAMs subpopulation with immunosuppressive function. The role of C1q in the prognosis and diagnosis of GC was demonstrated through plasma and tumor tissue from the GC cohort.
Saisai Gong, Yupeng Zhao, Sheng Yang, Tong Liu, Chengyun Li, Yun Zhou, Geyu Liang   +6 more
wiley   +1 more source

Sunitinib induces macrophage dysfunction and impaired tissue regeneration through suppression of PPARγ. [PDF]

Front Immunol
Zhang Z, Qiao Q, Li J, Li Q, Yang Y, Zhou Y, Huang H, Chen D, Wang Y, Guo Y.   +9 more
europepmc   +1 more source