Results 201 to 210 of about 66,281 (214)

Tankyrase‐2 regulates adipocyte differentiation through AMPK/mTOR signaling

The FEBS Journal, EarlyView.
Tankyrase 2 (TNKS2), a PARP family member, underpins adipocyte differentiation. TNKS2 controls LKB1 protein level, and consequently, the activity of the mTOR/AMPK system and adipocyte differentiation through a layered process. Pharmacological inhibition of TNKS2 leaves other PARPs and DNA repair active and therefore represents a novel target in ...
Boglarka Rauch, Gyula Ujlaki, Szilard Poliska, Nakayi Murahwa, Patrik Kovacs, Aladar Pettko‐Szandtner, Karen Uray, Peter Bai   +7 more
wiley   +1 more source

Potential Role for the Ubiquitin Ligase SIAH2 in Modulating Bone Morphology and Adiposity. [PDF]

Calcif Tissue Int
Scott MC, Ghosh B, Kilroy G, Lecka-Czernik B, Floyd ZE.   +4 more
europepmc   +1 more source

Novel targets in headache: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background This narrative review summarizes novel applications for the use of calcitonin gene‐related peptide (CGRP)‐targeted therapies that go beyond migraine, the latest updates with respect to targeting pituitary adenylate cyclase‐activating peptide (PACAP) as therapeutic in migraine, as well as exploring other more recently ...
Adriana Della Pietra, Peter J. Goadsby, Carolina Oldoni, Stephen Silberstein, Fred Cohen, Simon Akerman   +5 more
wiley   +1 more source

Lipid Metabolic Reprogramming in Periodontitis-Associated Alveolar Bone Remodeling: Mechanisms, Signaling Pathways, and Therapeutic Implications. [PDF]

Biomolecules
Wang J, Zhang X, Zhang Y, Wang X, Yang B, Hu X, Mao J, Zhang Z, Li H.   +8 more
europepmc   +1 more source

FGF8 alleviates LPS-induced acute lung injury <i>via</i> the PPARγ/ERK1/2 signalling pathway in mice. [PDF]

Ann Med
Song L, Liu X, Fang Q, Yu K, Zhuo D, He B, Chi C, Lin C, Lin M, Gong F, Liu Y.   +10 more
europepmc   +1 more source

Stigmasterol ameliorates obesity-associated insulin resistance by activating the PPARγ pathway and alleviating oxidative stress. [PDF]

Front Endocrinol (Lausanne)
Zhao Y, Wang F.
europepmc   +1 more source

Targeting PPAR-Regulated Pathways to Treat Cholestatic Liver Diseases: Novel Applications of Liquid Biopsies. [PDF]

Cells
Hayes CM, Cross DR, Achour B, Ghonem NS.
europepmc   +1 more source

FABP4 regulates inflammation and lipid transport via PPARγ signaling pathway in goose primary hepatocytes. [PDF]

Poult Sci
Liu X, Deng Z, Qin S, Liu H, Yang C, Deng Y, Ouyang Q, He C, Qu X.   +8 more
europepmc   +1 more source

Targeting the Fatty Acid Binding Protein 5-Specificity Protein 1 Axis Restores Enzalutamide Sensitivity by Suppressing Androgen Receptor/Androgen Receptor Splice Variant 7 Signaling: Implications for Prostate Cancer Therapy. [PDF]

World J Oncol
Abdulsamad SA, Naeem AA, Baashar A, Aldarmahi AA, Alamri FF, Abuarab NK, Alsahafi Z, Fallata G, Bokhari A, Alharbi AH, Ke Y, He G.   +11 more
europepmc   +1 more source