Association between PPARγ, PPARGC1A, and PPARGC1B genetic variants and susceptibility of gastric cancer in an Eastern Chinese population [PDF]
BMC Medical Genomics, 2022 Purpose Previous studies showed that peroxisome proliferator-activated receptor gamma (PPARγ) and PPARγ coactivator1 family (PPARGC1A and PPARGC1B) gene single nucleotide variants (SNVs)were strongly associated with cancer susceptibility.
Weifeng Tang +2 more
exaly +5 more sources
Analysis of PPARGC1B, RUNX3 and TBKBP1 Polymorphisms in Chinese Han Patients with Ankylosing Spondylitis: A Case-Control Study [PDF]
PLoS ONE, 2013 BACKGROUND: Susceptibility to and severity of ankylosing spondylitis (AS) are largely genetically determined. PPARGC1B, RUNX3 and TBKBP1 have recently been found to be associated with AS in patients of western European descent.
Wei Chai
exaly +5 more sources
Improvement in Facial Wrinkles Using Materials Enhancing PPARGC1B Expression Related to Mitochondrial Function [PDF]
Current Issues in Molecular BiologySkin aging is an unavoidable natural phenomenon caused by intrinsic and extrinsic factors. In modern society, the pursuit of a wrinkle-free and aesthetically appealing face has gained considerable prominence. Numerous studies have aimed at mitigating the
Hyejin Lee +4 more
doaj +4 more sources
miR136 regulates proliferation and differentiation of small tail han sheep preadipocytes [PDF]
Adipocyte, 2023 Low meat performance is the defect of Small Tail Han sheep. Intramuscular fat affects meat quality and largely determined by adipogenesis. In previous study, miR136 was showed one of differentially expressed microRNAs between preadipocytes and mature ...
Man Luo +5 more
doaj +2 more sources
Nanopore sequencing reveals methylation changes associated with obesity in circulating cell-free DNA from Göttingen Minipigs [PDF]
Epigenetics, 2023 Profiling of circulating cell-free DNA (cfDNA) by tissue-specific base modifications, such as 5-methylcytosines (5mC), may enable the monitoring of ongoing pathophysiological processes.
Markus Hodal Drag +9 more
doaj +2 more sources
Mechanistic insights into the PAI-1 inhibitor PAItrap3: enhancing lipid metabolism in adipose tissue of diabetic db/db mice [PDF]
Frontiers in PharmacologyObjectiveThis study aimed to investigate the effects of PAItrap3, a novel PAI-1 inhibitor, on lipid metabolism, and autophagy pathways in diabetic mice.Methodsdb/db diabetic mice were administered PAItrap3 (5.7 mg/kg/day, IV) for 21 consecutive days, and
Linxi Wang +7 more
doaj +2 more sources
Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer [PDF]
Carcinogenesis, 2006 The mitogen effect of the ovarian steroid estrogen is a strong risk factor for breast cancer development. This effect is mainly mediated by the estrogen receptor alpha, a hormone inducible transcription factor, which activates gene expression through recruiting multiple coactivators, such as PPARGC1A, PPARGC1B and EP300.
Dieter Niederacher +2 more
exaly +3 more sources
Pharmacogenomics Journal, 2023 Recently, the HLA-DQA1*05 (rs2097432) genetic variation has been reported to be linked to early infliximab (IFX) treatment failure in the Caucasian Crohn's disease (CD) population, but that evidence is scarce in the Asian population. This study aimed to investigate the relationship between rs2097432 and the cumulative discontinuation-free time of IFX ...
Katsushi Tokunaga +2 more
exaly +4 more sources
Preliminary Evidence of Blood DNA Methylation Changes in Pregnant Women Adhering to a Mediterranean Diet [PDF]
EpigenomesBackground/Objectives: Consumption of a Mediterranean diet (MD) has been associated with reduced incidence of non-communicable diseases and reduced overall mortality, with epigenomic effects representing plausible mediators.
Grace Tavelli +9 more
doaj +2 more sources
Mitochondrial energy metabolism genes as prognostic biomarkers in clear cell renal cell carcinoma via single-cell and bulk RNA sequencing analyses [PDF]
Discover OncologyThe rising incidence of clear cell renal cell carcinoma (ccRCC) with current treatments offering limited survival benefits and a poor prognosis. Mitochondrial abnormalities impact tumor immunity, progression, and metastasis, and the role of mitochondrial
Yinqi Peng +4 more
doaj +2 more sources