Results 41 to 50 of about 1,756 (151)

Genes Whose Gain or Loss-of-Function Increases Endurance Performance in Mice: A Systematic Literature Review

Frontiers in Physiology, 2019
Endurance is not only a key factor in many sports but endurance-related variables are also associated with good health and low mortality. Twin and family studies suggest that several endurance-associated traits are ≈50% inherited.
Fakhreddin Yaghoob Nezhad, Sander A. J. Verbrugge, Martin Schönfelder, Lore Becker, Martin Hrabě de Angelis, Martin Hrabě de Angelis, Martin Hrabě de Angelis, Henning Wackerhage   +7 more
doaj   +1 more source

A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis.

PLoS ONE, 2011
Activation of the host antibacterial defenses by the toll-like receptors (TLR) also selectively activates energy-sensing and metabolic pathways, but the mechanisms are poorly understood.
Timothy E Sweeney, Hagir B Suliman, John W Hollingsworth, Karen E Welty-Wolf, Claude A Piantadosi   +4 more
doaj   +1 more source

Gene and MicroRNA Expression Responses to Exercise; Relationship with Insulin Sensitivity. [PDF]

PLoS ONE, 2015
BACKGROUND:Healthy individuals on the lower end of the insulin sensitivity spectrum also have a reduced gene expression response to exercise for specific genes.
Carrie S McLean, Clinton Mielke, Jeanine M Cordova, Paul R Langlais, Benjamin Bowen, Danielle Miranda, Dawn K Coletta, Lawrence J Mandarino   +7 more
doaj   +1 more source

GENE POLYMORPHISMS OF ENDOTHELIAL DYSFUNCTION, COACTIVATORS OF MITOCHONDRIAL BIOGENESIS AND PLASMINOGEN/PLASMIN SYSTEM IN THE DEVELOPMENT OF CARDIOVASCULAR EVENTS IN RHEUMATOID ARTHRITIS

Научно-практическая ревматология, 2018
Cardiovascular catastrophes are the most common cause of death in patients with rheumatoid arthritis (RA). At the same time, the mechanism of progression of atherosclerotic lesions in the vascular bed in RA, including genetic factors, remains a matter of
A. V. Shevchenko, V. F. Prokofyev, M. O. Korolev, V. O. Omelchenko, V. I. Konenkov   +4 more
doaj   +1 more source

Comparative Analysis of Muscle Transcriptome between Pig Genotypes Identifies Genes and Regulatory Mechanisms Associated to Growth, Fatness and Metabolism.

PLoS ONE, 2015
Iberian ham production includes both purebred (IB) and Duroc-crossbred (IBxDU) Iberian pigs, which show important differences in meat quality and production traits, such as muscle growth and fatness.
Miriam Ayuso, Almudena Fernández, Yolanda Núñez, Rita Benítez, Beatriz Isabel, Carmen Barragán, Ana Isabel Fernández, Ana Isabel Rey, Juan F Medrano, Ángela Cánovas, Antonio González-Bulnes, Clemente López-Bote, Cristina Ovilo   +12 more
doaj   +1 more source

miR-21 promotes non-small cell lung cancer cells growth by regulating fatty acid metabolism

Cancer Cell International, 2019
Background Lung cancer is one of the most common malignant tumors worldwide. CD36 is a receptor for fatty acids and plays an important role in regulating fatty acid metabolism, which is closely related to tumorigenesis and development.
Kewei Ni, Dimin Wang, Heyun Xu, Fuyang Mei, Changhao Wu, Zhifang Liu, Bing Zhou   +6 more
doaj   +1 more source

FMR1, circadian genes and depression: suggestive associations or false discovery?

Journal of Circadian Rhythms, 2013
Background: There are several indications that malfunctions of the circadian clock contribute to depression. To search for particular circadian gene polymorphisms associated with depression, diverse polymorphisms were genotyped in two samples covering a ...
Daniel F Kripke, Caroline M Nievergelt, Gregory J Tranah, Sarah S Murray, Katharine M Rex, Alexandra P Grizas, Elizabeth K Hahn, Heon-Jeong Lee, John R Kelsoe, Lawrence E Kline   +9 more
doaj   +1 more source

Repeated Moderate and Severe Heat Exposure Has Divergent Effects on Skeletal Muscle Mitochondrial, Proteostatic and Neuromuscular Outcomes in Mice

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim Repeated heat exposure may promote adaptive remodeling or cumulative tissue burden depending on thermal dose, but its graded molecular and functional consequences during recovery remain unclear. We examined whether repeated moderate (39°C) and severe (41°C) whole‐body hyperthermia produce distinct skeletal muscle trajectories involving ...
Cansu Yakin, Cihan Suleyman Erdogan, Fatma Ozge Tuncel, Yunus Kosif, Bayram Yilmaz   +4 more
wiley   +1 more source

Relationship of PPARG, PPARGC1A, and PPARGC1B polymorphisms with susceptibility to hepatocellular carcinoma in an eastern Chinese Han population.

OncoTargets and therapy, 2018
PPARG, PPARGC1A, and PPARGC1B polymorphisms may be implicated in the development of cancer.In this study, we selected PPARG rs1801282 C>G and rs3856806 C>T, PPARGC1A rs2970847 C>T, and PPARGC1B rs7732671 G>C and rs17572019 G>A single-nucleotide polymorphisms to explore the relationship between these polymorphisms and hepatocellular carcinoma (HCC) risk.
Zhang,Sheng, Jiang,Jiakai, Chen,Zhan, Wang,Yafeng, Tang,Weifeng, Chen,Yu, Liu,Longgen   +6 more
openaire   +3 more sources

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, Volume 13, Issue 38, 9 July 2026.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source