Results 51 to 60 of about 1,756 (151)

Candidate genes for plasma triglyceride, FFA, and glucose revealed from an intercross between inbred mouse strains NZB/B1NJ and NZW/LacJ*s⃞

Journal of Lipid Research, 2008
To identify the genes controlling plasma concentrations of triglycerides (TGs), FFAs, and glucose, we carried out a quantitative trait loci (QTL) analysis of the closely related mouse strains New Zealand Black (NZB/B1NJ) and New Zealand White (NZW/LacJ),
Zhiguang Su, Shirng-wern Tsaih, Jin Szatkiewicz, Yuan Shen, Beverly Paigen   +4 more
doaj   +1 more source

Mechanistic Review of Topical Therapies Targeting Dermal Fibroblasts in Skin Aging and Rejuvenation [PDF]

J Cosmet Dermatol
ABSTRACT Background Skin aging appears in multiple forms, including wrinkles, sagging, scarring, atrophy, and photoaging. Although each phenotype has distinct biological features, all are rooted in dermal fibroblast dysfunction. This review examines the molecular pathways underlying these conditions and evaluates topical interventions designed to ...
Akaberi S, Esfandiyari M, Ahmadi Ashtiani H.   +2 more
europepmc   +2 more sources

Additional file 6 of Association between PPARγ, PPARGC1A, and PPARGC1B genetic variants and susceptibility of gastric cancer in an Eastern Chinese population

, 2023
Additional file 6. Supplementary Primers.
Chen, Boyang, Wang, Yafeng, Tang, Weifeng, Chen, Yu, Liu, Chao, Kang, Mingqiang, Xie, Jinbiao   +6 more
openaire   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, Volume 10, Issue 10, 22 May 2026.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

EPAS1 is associated with human muscle fiber composition and endurance phenotypes

Physiological Reports, Volume 14, Issue 10, May 2026.
Abstract A recent study reported that endothelial PAS domain protein 1 (EPAS1; hypoxia‐inducible factor 2α) acts downstream of PGC‐1α to regulate the slow‐twitch muscle fiber program in mice, yet its role in human physiology and exercise adaptation remains unclear.
Albina Z. Dautova, Elena V. Valeeva, Ekaterina A. Semenova, Fanis A. Mavliev, Alexey A. Zverev, Andrey S. Nazarenko, George John, Andrey V. Zhelankin, Andrey K. Larin, Nikolay A. Kulemin, Rinat I. Sultanov, Edward V. Generozov, Ildus I. Ahmetov   +12 more
wiley   +1 more source

4249 Markers of mitochondrial biogenesis, fusion and architecture are disturbed in PBMC from war veterans with posttraumatic stress disorder (PTSD)

Journal of Clinical and Translational Science, 2020
OBJECTIVES/GOALS: The aim of this study was to define the transcription profiles of the molecular markers of mitochondrial biogenesis and fusion/architecture, and the markers of mtDNA copy numbers in the peripheral blood mononuclear cells (PBMCs) from ...
Silvana Andric, Aleksandra Markovic, Mirko Milosevic, Sava Radovic, Isidora Starovlah, Jelena Brkljacic, Danijela Vojnovic Milutinovic, Gordana Matic, Tatjana Kostic   +8 more
doaj   +1 more source

RBFOX1 Dysfunction Unlocks APOE4‐Associated Microglial Genesis and Exacerbates Alzheimer's Pathology in Human Cerebral Organoids

Exploration, Volume 6, Issue 2, April 2026.
Genomic studies implicate RBFOX1 in Alzheimer's disease (AD) risk, highlighting the need to define its role and interactions with other risk factors. Here, CRISPR/Cas9‐mediated RBFOX1 loss in APOE4 human cerebral organoids induces autonomous microglial genesis and accelerates AD pathology, revealing a protective role of RBFOX1 and establishing a model ...
Bowen Zhang, Changjie Shi, Jiayi Zhao, Qiuhong Hua, Houchun Zhang, Hailin Gao, Yuanyuan Qian, Jiaxue Cha, Jing Li, Jiayao Chen, Tae‐Hyung Kim, Jianhuang Xue, Yujun Hou, Ru Zhang   +13 more
wiley   +1 more source

The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology

International Journal of Endocrinology, 2015
MicroRNA-378a (miR-378a, previously known as miR-378) is one of the small noncoding RNA molecules able to regulate gene expression at posttranscriptional level.
Bart Krist, Urszula Florczyk, Katarzyna Pietraszek-Gremplewicz, Alicja Józkowicz, Jozef Dulak   +4 more
doaj   +1 more source

Muscle Transcriptome Analysis Reveals Molecular Pathways Related to Oxidative Phosphorylation, Antioxidant Defense, Fatness and Growth in Mangalitsa and Moravka Pigs

Animals, 2021
This work was aimed at evaluating loin transcriptome and metabolic pathway differences between the two main Serbian local pig breeds with divergent characteristics regarding muscle growth and fatness, as well as exploring nutrigenomic effects of tannin ...
Yolanda Núñez, Čedomir Radović, Radomir Savić, Juan M. García-Casco, Marjeta Čandek-Potokar, Rita Benítez, Dragan Radojković, Miloš Lukić, Marija Gogić, María Muñoz, Luca Fontanesi, Cristina Óvilo   +11 more
doaj   +1 more source

Additional file 5 of Association between PPARγ, PPARGC1A, and PPARGC1B genetic variants and susceptibility of gastric cancer in an Eastern Chinese population

, 2023
Additional file 5. Supplementary Table S5.
Chen, Boyang, Wang, Yafeng, Tang, Weifeng, Chen, Yu, Liu, Chao, Kang, Mingqiang, Xie, Jinbiao   +6 more
openaire   +1 more source