Results 21 to 30 of about 1,756 (151)

Inhibitory Effect of Luteolin on Spike S1 Glycoprotein-Induced Inflammation in THP-1 Cells via the ER Stress-Inducing Calcium/CHOP/MAPK Pathway [PDF]

Pharmaceuticals
Background/Objectives: The global SARS-CoV-2 outbreak has escalated into a critical public health emergency, with the spike glycoprotein S1 subunit of SARS-CoV-2 (spike-S1) linked to inflammation in lung tissue and immune cells.
Sonthaya Umsumarng, Sivamoke Dissook, Punnida Arjsri, Kamonwan Srisawad, Pilaiporn Thippraphan, Apiwat Sangphukieo, Patcharawadee Thongkumkoon, Pornngarm Dejkriengkraikul   +7 more
doaj   +2 more sources

Inflammasome genes polymorphisms and susceptibility to gout. Is there a link?

Revista de Investigación Clínica, 2022
Background: The inflammatory response in gout disease is induced by the activation of NLR family pyrin domain-containing 3 (NLPR3) signaling pathway mediated by IL-1β release. Objective: The objective of the study was to determine the association between
Denise Clavijo-Cornejo, Alberto López-Reyes, Esteban Cruz-Arenas, Leonor Jacobo-Albavera, Daniel Rivera-Tlaltzicapa, Adriana Francisco-Balderas, Mayra Domínguez-Pérez, Pablo Romero-Morelos, Janitzia Vázquez-Mellado, Luis H. Silveira, Carlos Pineda, Gabriela Martínez-Nava, Marwin Gutierrez   +12 more
doaj   +1 more source

Brd9 antagonism induces beige adipocytes in white adipose tissues and protects against diet-induced obesity. [PDF]

Obesity (Silver Spring)
Abstract Objective Thermogenic beige adipocytes emerge in white adipose tissue (WAT) under certain physiological and pathological conditions, leading to increased energy expenditure, insulin sensitivity, and glucose tolerance. The induction of beige adipocyte formation represents a promising therapeutic approach for obesity and associated chronic ...
Liu Y, Yin A, Seese K, Fu W, Yin H.
europepmc   +2 more sources

Differential regulation of the PGC family of genes in a mouse model of Staphylococcus aureus sepsis. [PDF]

PLoS ONE, 2010
The PGC family of transcriptional co-activators (PGC-1alpha [Ppargc1a], PGC-1beta [Ppargc1b], and PRC [Pprc]) coordinates the upregulation of mitochondrial biogenesis, and Ppargc1a is known to be activated in response to mitochondrial damage in sepsis ...
Timothy E Sweeney, Hagir B Suliman, John W Hollingsworth, Claude A Piantadosi   +3 more
doaj   +1 more source

Resveratrol Affects Cell Activities, Induces Apoptosis and Regulates AMPK Signaling Pathway in Pleural Mesothelioma Cells. [PDF]

FASEB J
This graphical abstract presents the study of Resveratrol as a potential adjuvant therapy for Pleural Mesothelioma (PM), focusing on the epithelioid and biphasic histotypes using IST‐MES 2 and MSTO‐211H cell lines. Following 24 h of cell seeding, the cells were treated with Resveratrol, and various analyses were conducted to assess its effects.
Iaquinta MR, De Pace R, Benkhalqui A, Pesaresi C, Patergnani S, Righes G, Pinton P, Tognon M, Martini F, Mazzoni E.   +9 more
europepmc   +2 more sources

Novel Polymorphisms of Adrenergic, Alpha-1B-, Receptor and Peroxisome Proliferator-activated Receptor Gamma, Coactivator 1 Beta Genes and Their Association with Egg Production Traits in Local Chinese Dagu Hens [PDF]

Asian-Australasian Journal of Animal Sciences, 2016
Adrenergic, alpha-1B-, receptor (ADRA1B) and peroxisome proliferator-activated receptor gamma, coactivator 1 beta (PPARGC1B) genes are involved in regulation of hen ovarian development.
F. Mu, Y. Jing, N. Qin, H. Y. Zhu, D. H. Liu, S. G. Yuan, R. F. Xu   +6 more
doaj   +1 more source

PPARGC1B Is Associated with Nontraumatic Osteonecrosis of the Femoral Head

Journal of Bone and Joint Surgery, 2020
Background:Previous studies have demonstrated the influence of heritable factors on the development of nontraumatic osteonecrosis of the femoral head (ONFH). We hypothesized that genetic variation is associated with an increased risk of ONFH, and that variants could be identified by a genomewide association study (GWAS).Methods:Using data collected ...
Yanfei Zhang, Thomas R. Bowen, Steven A. Lietman, Michael Suk, Marc S. Williams, Ming Ta Michael Lee   +5 more
openaire   +3 more sources

circRNA Profiling Reveals an Abundant circFUT10 that Promotes Adipocyte Proliferation and Inhibits Adipocyte Differentiation via Sponging let-7

Molecular Therapy: Nucleic Acids, 2020
Adipose development is regulated by a series of complex processes, and non-coding RNAs (ncRNAs), including circular RNAs (circRNAs), play important roles in regulating proliferation and differentiation of adipocytes.
Rui Jiang, Hui Li, Jiameng Yang, Xuemei Shen, Chengchuang Song, Zhaoxin Yang, Xiaogang Wang, Yongzhen Huang, Xianyong Lan, Chuzhao Lei, Hong Chen   +10 more
doaj   +1 more source

MyoD Regulates Skeletal Muscle Oxidative Metabolism Cooperatively with Alternative NF-κB

Cell Reports, 2016
MyoD is a key regulator of skeletal myogenesis that directs contractile protein synthesis, but whether this transcription factor also regulates skeletal muscle metabolism has not been explored. In a genome-wide ChIP-seq analysis of skeletal muscle cells,
Jonathan Shintaku, Jennifer M. Peterson, Erin E. Talbert, Jin-Mo Gu, Katherine J. Ladner, Dustin R. Williams, Kambiz Mousavi, Ruoning Wang, Vittorio Sartorelli, Denis C. Guttridge   +9 more
doaj   +1 more source

Depicting the Implication of miR-378a in Cancers

Technology in Cancer Research & Treatment, 2022
MicroRNA-378a (miR-378a), including miR-378a-3p and miR-378a-5p, are encoded in PPARGC1B gene. miR-378a is essential for tumorigenesis and is an independent prognostic biomarker for various malignant tumors.
Yuelan Qin BM, Renba Liang MD, PhD, Pingan Lu BS, Lin Lai MD, PhD, Xiaodong Zhu MD, PhD   +4 more
doaj   +1 more source