Landscape of N6-methyladenosine (m6A) methylation in porcine cells identifies candidate genes associated with porcine epidemic diarrhea virus infection [PDF]
Frontiers in MicrobiologyPorcine epidemic diarrhea virus (PEDV) infection leads to serious intestinal disease in piglets, often leading to high mortality rates and substantial economic losses. Understanding host–PEDV interactions is crucial for PEDV therapeutic strategies.
Xia Dong +7 more
doaj +2 more sources
Levamisole suppresses adipogenesis of aplastic anaemia‐derived bone marrow mesenchymal stem cells through ZFP36L1‐PPARGC1B axis [PDF]
Journal of Cellular and Molecular Medicine, 2018 AbstractAplastic anaemia (AA) is a life‐threatening hematopoietic disorder characterized by hypoplasia and pancytopenia with increasing fat cells in the bone marrow (BM). The BM‐derived mesenchymal stem cells (MSCs) from AA are more susceptible to be induced into adipogenic differentiation compared with that from control, which may be causatively ...
Chen Mingtai
exaly +3 more sources
Genetic variation of ESR1 and its co-activator PPARGC1B is synergistic in augmenting the risk of estrogen receptor-positive breast cancer [PDF]
Breast Cancer Research, 2011 Abstract Introduction Given the role of estrogen in breast carcinogenesis and the modification of estrogen receptor (ER) activity by its biochemical cofactors, we hypothesize that genetic variation within ER cofactor genes alters cellular response to estrogen exposure and consequently modifies the risk ...
Guoliang Li, Ks Chia, Jianjun Liu
exaly +3 more sources
Interconnected study of molecular pathways: miR-137 as a central element at the intersection of lipid metabolism and prostate carcinogenesis [PDF]
Einstein (São Paulo)Objective To evaluate the roles of miR-137 and its target genes in lipid metabolism and prostate tumorigenesis. Methods We used a series of bioinformatic approaches to establish the relationship between miR-137 and its target genes.
Karina Serafim da Silva +10 more
doaj +2 more sources
Human Genetic Variation at rs10071329 Correlates With Adiposity-Related Traits, Modulates PPARGC1B Expression, and Alters Brown Adipocyte Function. [PDF]
DiabetesHuman genetic variation in PPARGC1B has been associated with adiposity, but the genetic variants that affect PPARGC1B expression have not been experimentally determined. Here, guided by previous observational data, we used clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9 (CRISPR/
Huang M +7 more
europepmc +5 more sources
Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A2 formation and with cardiovascular event free survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) [PDF]
Atherosclerosis, 2018 BACKGROUND AND AIMS: Elevated urinary 11-dehydro thromboxane B2 (TxB2), a measure of thromboxane A2 formation in vivo, predicts future atherothrombotic events. To further understand this relationship, the genetic determinants of 11-dehydro TxB2 and their associations with cardiovascular morbidity were investigated in this study.
Eoin O'Brien +2 more
exaly +5 more sources
Astaxanthin supplementation in Arabian racing horses mitigates oxidative stress and inflammation in peripheral blood mononuclear cells through enhanced mitophagy [PDF]
Scientific ReportsAstaxanthin, a strong antioxidant carotenoid, has shown promising features in mitigating inflammation and oxidative stress and so that has been considered as a supplement for high-performance animals.
Beata Giercuszkiewicz-Hecold +4 more
doaj +2 more sources
Alterations in the molecular control of mitochondrial turnover in COPD lung and airway epithelial cells [PDF]
Scientific ReportsAbnormal mitochondria have been observed in bronchial- and alveolar epithelial cells of patients with chronic obstructive pulmonary disease (COPD).
Christy B. M. Tulen +12 more
doaj +2 more sources
Medična Informatika ta Inženerìâ, 2013 To establishing the possibility of assessing genetic iinherited predisposition to various sports, the differences in the distribution of genotypes of the complex polymorphisms in groups of athletes, specializing in sports with different types of energy ...
S. B. Drozdovska +3 more
doaj +4 more sources
Maternal Nutrient Excess Induces Stress Signaling and Decreases Mitochondrial Number in Term Fetal Baboon Skeletal Muscle [PDF]
BiologyMaternal obesity programs the fetus for increased risk of chronic disease development in early life and adulthood. We hypothesized that maternal nutrient excess leads to fetal inflammation and impairs offspring skeletal muscle mitochondrial biogenesis in
Xu Yan +4 more
doaj +2 more sources