Regulation of steroid hormone receptor function by the 52-kDa FK506-binding protein (FKBP52) [PDF]
, 2011 The large FK506-binding protein FKBP52 has been characterized as an important positive regulator of androgen, glucocorticoid and progesterone receptor signaling pathways.
Cox, Marc B. +3 more
core +2 more sources
PpiD is a player in the network of periplasmic chaperones in
BMC Microbiology, 2010 Background The inner membrane-anchored periplasmic folding factor PpiD is described as a parvulin-like peptidyl prolyl isomerase (PPIase) that assists in the maturation of the major beta-barrel outer membrane proteins (OMPs) of Escherichia coli.
Behrens-Kneip Susanne +2 more
doaj +1 more source
Molecular characterization of cyclophilin A-like protein from Piriformospora indica for its potential role to abiotic stress tolerance in E. coli [PDF]
, 2013 BACKGROUND: Cyclophilins (CyP), conserved in all genera, are known to have regulatory responses of various cellular processes including stress tolerance. Interestingly, CyP has a crucial role as peptidyl-prolyl cis–trans isomerases (PPIases). Our earlier
Dipesh Trivedi +4 more
core +1 more source
Nuclear import of Pin1 is mediated by a novel sequence in the PPIase domain [PDF]
FEBS Letters, 2008 MINT‐6803345: St3 (uniprotkb:P40763) and importin alpha 5 (uniprotkb:P52294) physically interact (MI:0218) by anti tag coimmunoprecipitation (MI:0007)
Lufei, Chengchen, Cao, Xinmin
openaire +2 more sources
Abnormal type I collagen post-translational modification and crosslinking in a cyclophilin B KO mouse model of recessive osteogenesis imperfecta. [PDF]
PLoS Genetics, 2014 Cyclophilin B (CyPB), encoded by PPIB, is an ER-resident peptidyl-prolyl cis-trans isomerase (PPIase) that functions independently and as a component of the collagen prolyl 3-hydroxylation complex.
Wayne A Cabral +14 more
doaj +1 more source
Enzymes: An integrated view of structure, dynamics and function [PDF]
, 2006 Microbes utilize enzymes to perform a variety of functions. Enzymes are biocatalysts working as highly efficient machines at the molecular level. In the past, enzymes have been viewed as static entities and their function has been explained on the basis ...
PratulK Agarwal
core +2 more sources
Components of SurA required for outer membrane biogenesis in uropathogenic Escherichia coli.
PLoS ONE, 2008 BackgroundSurA is a periplasmic peptidyl-prolyl isomerase (PPIase) and chaperone of Escherichia coli and other Gram-negative bacteria. In contrast to other PPIases, SurA appears to have a distinct role in chaperoning newly synthesized porins destined for
Kristin M Watts, David A Hunstad
doaj +1 more source
Frontiers in Microbiology, 2022 Brucella spp. are the etiological agent of animal and human brucellosis. We have reported previously that cyclophilins of Brucella (CypA and CypB) are upregulated within the intraphagosomal replicative niche and required for stress adaptation and host ...
Emanuel J. Muruaga +5 more
doaj +1 more source
Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity. [PDF]
, 2016 BackgroundHIV-associated neurocognitive disorders (HAND) continue to be a common morbidity associated with chronic HIV infection. It has been shown that HIV proteins (e.g., gp120) released from infected microglial/macrophage cells can cause neuronal ...
Achim, Cristian +9 more
core +1 more source
Journal of Integrative Plant Biology, EarlyView.In soybean, the trihelix transcription factor GmGT‐2F positively regulates the expression of the α‐galactosidase gene GmAGAL, thereby modulating seed oil content. The cyclophilin GmCYP2 interacts with GmGT‐2F and suppresses GmAGAL activation. Haplotype diversity analysis of GmGT‐2F, GmCYP2, and GmAGAL identified favorable haplotype combinations ...
Shuangzhe Li +6 more
wiley +1 more source