Results 71 to 80 of about 7,127 (231)

Diversity oriented biosynthesis via accelerated evolution of modular gene clusters. [PDF]

, 2017
Erythromycin, avermectin and rapamycin are clinically useful polyketide natural products produced on modular polyketide synthase multienzymes by an assembly-line process in which each module of enzymes in turn specifies attachment of a particular ...
Alanine, Alexander, Alt, Silke, Carter, Guy T, Chao, Suzan Keen, Coates, Nigel J, Graziani, Edmund I, Gregory, Matthew A, Heine, Daniel, Higginbotham, Sarah J, Hold, Adam, Kendrew, Steve G, Koehn, Frank E, Leadlay, Peter F, Martin, Christine J, McDonald, Leonard, Moss, Steven J, Norville, Isobel H, Nur-E-Alam, Mohammad, Overvoorde, Lois, Pogwizd, Joanna, Radzom, Markus, Ratni, Hasane, Rodríguez Sarmiento, Rosa María, Rudder, Steven, Samborskyy, Markiyan, Sarkar-Tyson, Mitali, Sheehan, Lesley S, Stanley-Smith, Anna E, Steward, Lucinda, Warneck, Tony, Wilkinson, Barrie, Wlodek, Aleksandra   +31 more
core   +2 more sources

Genome‐wide association study identifies consistent genomic loci for yield and nutritional quality in Ethiopian sorghum landraces

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Identifying genomic regions linked to yield and quality is crucial for sorghum (Sorghum bicolor L.) improvement, but limited studies on its genome and diversity hinder breeding efforts. This study aimed to identify phenotypic variance and common quantitative trait nucleotides (QTNs) associated with genomic regions linked with grain yield and ...
Chalachew Endalamaw, Temesgen M. Menamo, Firezer G. Kebede, Zeleke Wondimu, Hailekiros Tadesse Tekle, Kwame Shamuyarira, Angeline Jacoby, Maryke Tine Labuschagne   +7 more
wiley   +1 more source

The FKBP52 Cochaperone Acts in Synergy with β-Catenin to Potentiate Androgen Receptor Signaling. [PDF]

PLoS ONE, 2015
FKBP52 and β-catenin have emerged in recent years as attractive targets for prostate cancer treatment. β-catenin interacts directly with the androgen receptor (AR) and has been characterized as a co-activator of AR-mediated transcription.
Cheryl Storer Samaniego, Ji Ho Suh, Arundhati Chattopadhyay, Karen Olivares, Naihsuan Guy, Jeffrey C Sivils, Prasenjit Dey, Fumiaki Yumoto, Robert J Fletterick, Anders M Strom, Jan-Åke Gustafsson, Paul Webb, Marc B Cox   +12 more
doaj   +1 more source

Microbial Peptidyl-Prolyl cis / trans Isomerases (PPIases): Virulence Factors and Potential Alternative Drug Targets [PDF]

Microbiology and Molecular Biology Reviews, 2014
SUMMARY Initially discovered in the context of immunomodulation, peptidyl-prolyl cis/trans isomerases (PPIases) were soon identified as enzymes catalyzing the rate-limiting protein folding step at peptidyl bonds preceding proline residues.
Unal, Can M., Steinert, Michael
openaire   +3 more sources

IgE to cyclophilin Bet v 7 triggers mast cell activation and mediates cross‐reactivity with Ara h 18 in children with seasonal allergic rhinitis

Pediatric Allergy and Immunology, Volume 37, Issue 3, March 2026.
Abstract Background Panallergens are ubiquitously expressed molecules that may drive IgE sensitization across diverse allergen sources, thereby shaping complex clinical phenotypes such as asthma and pollen–food allergy syndrome (PFAS). Although several panallergen families have been extensively characterized, unexplained sensitization patterns are ...
Wilhelm Sponholz, Carolin Steinert, Francesco Monnati, Ekaterina Potapova, Jonas Lidholm, Lars Mattsson, Enrico Scala, Roberto Bernardini, Carlo Caffarelli, Antonella Casani, Rosa Cervone, Elisabetta Del Duca, Pasquale Comberiati, Giovanna De Castro, Michele Miraglia Del Giudice, Iride Dello Iacono, Andrea Di Rienzo Businco, Marcella Gallucci, Arianna Giannetti, Viviana Moschese, Elena Varin, Annamaria Bianchi, Mauro Calvani, Tullio Frediani, Francesco Macrì, Nunzia Maiello, Francesco Paravati, Umberto Pelosi, Diego Peroni, Giuseppe Pingitore, Mariangela Tosca, Anna Maria Zicari, Giampaolo Ricci, Riccardo Asero, Salvatore Tripodi, Paolo Maria Matricardi, Joerg Scheffel   +36 more
wiley   +1 more source

Phosphate Resupply Differentially Impacts the Shoot and Root Proteomes of Arabidopsis thaliana Seedlings

Plant, Cell &Environment, Volume 49, Issue 3, Page 1598-1616, March 2026.
ABSTRACT Phosphate (Pi) is an essential macronutrient for plant development that is often limited in soil. Plants have evolved dynamic biochemical, physiological and morphological adaptations to cope with Pi deficiency, known as the Pi starvation response (PSR).
Milena A. Smith, Lauren E. Grubb, Kirsten H. Benidickson, Devang Mehta, William C. Plaxton, R. Glen Uhrig   +5 more
wiley   +1 more source

TAL effectors target the C-terminal domain of RNA polymerase II (CTD) by inhibiting the prolyl-isomerase activity of a CTD-associated cyclophilin. [PDF]

PLoS ONE, 2012
Transcriptional activator-like (TAL) effectors of plant pathogenic bacteria function as transcription factors in plant cells. However, how TAL effectors control transcription in the host is presently unknown.
Mariane Noronha Domingues, Bruna Medeia de Campos, Maria Luiza Peixoto de Oliveira, Uli Quirino de Mello, Celso Eduardo Benedetti   +4 more
doaj   +1 more source

Requirement of a mip-Like Gene for Virulence in the Phytopathogenic Bacterium Xanthomonas campestris pv. campestris

Molecular Plant-Microbe Interactions, 2007
Macrophage infectivity potentiators (Mips) are FKBP domain-containing proteins reported as virulence factors in several human pathogens, such as members of genera Legionella, Salmonella and Chlamydia.
Ning Zang, Dong-Jie Tang, Mei-Liang Wei, Yong-Qiang He, Baoshan Chen, Jia-Xun Feng, Jing Xu, Yong-Qi Gan, Bo-Le Jiang, Ji-Liang Tang   +9 more
doaj   +1 more source

The SlyD metallochaperone targets iron-sulfur biogenesis pathways and the TCA cycle

mBio, 2023
Control of protein folding is a conserved function in all domains of life. The ubiquitous peptidyl-prolyl cis-trans isomerases (PPIases) catalyze the cis/trans-isomerization of peptidyl-prolyl bonds, often a rate-limiting step for protein folding ...
Milica Denic, Evelyne Turlin, Deborah B. Zamble, Jean-Michel Betton, Daniel Vinella, Hilde De Reuse   +5 more
doaj   +1 more source

Management of cytoskeleton architecture by molecular chaperones and immunophilins [PDF]

, 2011
Cytoskeletal structure is continually remodeled to accommodate normal cell growth and to respond to pathophysiological cues. As a consequence, several cytoskeleton-interacting proteins become involved in a variety of cellular processes such as cell ...
Adachi, Albanese, Alejandra G. Erlejman, Ammer, Aravind, Aylett, Bailey, Banerjee, Basso, Bechtold, Beck, Benndorf, Bercovich, Bivi, Bjorkdahl, Bork, Brackley, Brackley, Broadley, Buee, Burke, Byrd, Cabeen, Capetanaki, Chadli, Chambraud, Chambraud, Chan, Cheung, Cheung, Cheung, Colo, Cox, Creppe, Csermely, Cuellar, Czar, Czar, Czar, Dabir, Davies, Defeu Soufo, Dekker, DeZwaan, Dickey, Ding, Donnelly, Dou, Duan, Dunn, Dutsch-Wicherek, Echeverria, Ehler, Elbi, Elliott, Ellis, Erickson, Feldman, Fisher, Fisher, Fortugno, Fulda, Galigniana, Galigniana, Galigniana, Galigniana, Galigniana, Galigniana, Galigniana, Galigniana, Galigniana, Gallo, Gao, Gilyarov, Gold, Gold, Goldbaum, Goldfarb, Gong, Graciela Piwien-Pilipuk, Grad, Grantham, Green, Gross, Guillozet-Bongaarts, Hammond, Harrell, Hartl, Herrmann, Hinds, Horwich, Hotulainen, Hut, Héctor R. Quintá, Jakob, Jana, Jinwal, Jo, Kadota, Kampinga, Kanelakis, Kang, Karagoz, Kaverina, Khatau, Klucken, Kostenko, Kovacs, Kubota, Lange, Lavoie, Lavoie, Lee, Liao, Lin, Liu, Liu, Luo, Luo, Mariana Lagadari, Mario D. Galigniana, Mayer, Meierhofer, Michie, Mogilner, Morimoto, Muchowski, Murphy, Natalia M. Galigniana, Neckers, Omary, Pallari, Park, Perrot-Applanat, Pratt, Pratt, Pratt, Quinta, Quintá, Reed, Richter, Rycyzyn, Sah, Sahara, Salminen, Sarria, Sausville, Sellin, Shih, Shim, Shimamoto, Shimura, Silverstein, Silverstein, Sinars, Solit, Spiess, Sreedhar, Szeverenyi, Tam, Tanioka, Thomas, Thulasiraman, Toivola, Toivola, Trepel, Van den Abbeele, Vaughan, Verhey, Vicent, Vogel, Wade, Weaver, Weis, Westermann, Wiesner, Wirtz, Wright, Wu, Zhai, Zhao, Zilberman   +181 more
core   +1 more source