Results 61 to 70 of about 289 (101)

Developing Dictyostelium discoideum as a model to study the synthesis and metabolism of inositol pyrophosphates and inorganic polyphosphate [PDF]

, 2016
Inositol pyrophosphates and inorganic polyphosphate (polyP) represent two of the most phosphate-rich molecules in the cell. However, the synthesis, metabolism and function of these “high-energy” molecules are not well understood.
Livermore, TM
core  

PPIP5K2 and PCSK1 are Candidate Genetic Contributors to Familial Keratoconus [PDF]

, 2019
Keratoconus (KC) is the most common corneal ectatic disorder affecting >300,000 people in the US. KC normally has its onset in adolescence, progressively worsening through the third to fourth decades of life.
Abu-Amero, Khaled K, Al-Muammar, Abdulrahman, Bykhovskaya, Yelena, Chen, Zhong, Drewry, Michelle D, Estes, Amy, Gu, Chunfang, Khaled, Mariam Lofty, Kuo, Anthony, Li, Xiaohui, Liu, Alice, Liu, Yutao, Lu, Xiaowen, McNabb, Ryan P, Mysona, Barbara A, Parker, Emily, Porter, Louise F, Rabinowitz, Yaron S, Rotter, Jerome I, Shears, Stephen B, Smith, Sylvia B, Wang, Jing, Watsky, Mitchell A, Xu, Hongyan, Yu, Hongfang   +24 more
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Characterization of PPIP5Ks using pharmacological and chemical biology approaches

This thesis describes the development of a chemical tool directed against the kinase domain of PPIP5K. Furthermore, the functions of the phosphatase domain were biochemically characterized, complementing structural investigations. A high-throughput screening was carried out to identify lead structures for PPIP5K2 kinase inhibitors, yielding a single ...
openaire   +1 more source

Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in the enteric nervous system [PDF]

, 2023
Inositol pyrophosphates regulate diverse physiological processes; to better understand their functional roles, assessing their tissue-specific distribution is important.
Fujii, Natsuko, Hirabayashi, Kenichi, Hori, Shuho, Iijima, Takatoshi, Ito, Masatoshi, Jessen, Henning J, Kakimoto, Yu, Kikuchi, Kenta, Kohara, Saori, Kurotaki, Daisuke, Nagata, Eiichiro, Saiardi, Adolfo, Tanaka, Masayuki, Wittwer, Christopher   +13 more
core  

Inositol Pyrophosphates: Energetic, Omnipresent and Versatile Signalling Molecules [PDF]

, 2017
Inositol pyrophosphates (PP-IPs) are a class of energy-rich signalling molecules found in all eukaryotic cells. These are derivatives of inositol that contain one or more diphosphate (or pyrophosphate) groups in addition to monophosphates.
A Burton, A Burton, A Chakraborty, A Chakraborty, A Chakraborty, A Feoktistova, A Lonetti, A Nagel, A Prasad, A Saiardi, A Saiardi, A Saiardi, A Saiardi, A Saiardi, A Saiardi, A Saiardi, A Saiardi, AM Marmelstein, AM Riley, AS Carroll, BH Morrison, BH Morrison, BH Morrison, BH Morrison, BH Morrison, C Auesukaree, C Azevedo, C Azevedo, C Azevedo, C Fu, C Gu, C Illies, C Ye, CJ Barker, CJ Barker, CJ Barker, CP Downes, D Laha, DM Landis, E Bucking-Throm, E Dubois, E Nagata, E Nagata, E Nagata, EA Steidle, F Pisani, F Rao, F Rao, F Rao, FS Menniti, GW Mayr, GW Mayr, H Banfic, H Lin, H Wang, H Wang, H Wang, HR Luo, HR Luo, HR Luo, I Corthesy-Theulaz, I Pavlovic, J Kaur, J Li, J Worley, JH Choi, JH Conway, K Choi, K Choi, K Gardner, KN Huang, L Stephens, LM Yates, M Bennett, M Chanduri, M Desai, M Hothorn, M Rosner, M Wu, M Wu, MA Koldobskiy, MA Koldobskiy, MC Glennon, ME Lenburg, MM Tsui, MP Thomas, MS Wilson, MS Wilson, NA Gokhale, NA Gokhale, NK Pulloor, O Losito, P Draskovic, PC Fridy, Q Zhu, R Bhandari, R Bhandari, R Taylor Jr, R Wild, RF Irvine, RH Michell, RS Jadav, RS Jadav, RS Kilari, S Capolicchio, S Ghosh, S Mulugu, SB Shears, SB Shears, SB Shears, SB Shears, SB Shears, SC Li, SG Thota, SG Thota, SJ York, SM Onnebo, ST Safrany, ST Yong, T Laussmann, T Wundenberg, T Wundenberg, T-S Lee, W Yu, X Pesesse, Y Matsuoka, Y Xu, YS Lee, YS Lee, Z Szijgyarto, Z Zhang   +130 more
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The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment [PDF]

, 2012
Jeremy D. Weaver, Huanchen Wang, Stephen B. Shears   +2 more
openalex   +1 more source

Control of plant phosphate homeostasis by inositol pyrophosphates and the SPX domain. [PDF]

, 2018
Proteins containing a SPX domain are involved in phosphate (Pi) homeostasis, including Pi transport and adaptation to Pi deficiency. The SPX domain harbors a basic surface binding Pi at low affinity and inositol pyrophosphates (PP-InsPs) at high affinity.
Hothorn, M., Jung, J.Y., Poirier, Y., Ried, M.K.   +3 more
core   +1 more source

PPIP5K [PDF]

, 2016
Stephen B. Shears
openalex   +1 more source

Harnessing {13}^C-labeled myo-inositol to interrogate inositol phosphate messengers by NMR [PDF]

, 2019
Inositol poly- and pyrophosphates (InsPs and PP-InsPs) are an important group of metabolites and mediate a wide range of processes in eukaryotic cells. To elucidate the functions of these molecules, robust techniques for the characterization of inositol ...
Fiedler, D, Harmel, RK, Nguyen Trung, M, Puschmann, R, Saiardi, A, Schmieder, P   +5 more
core  

Identification of a functional nuclear translocation sequence in hPPIP5K2 [PDF]

, 2015

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