An ATP-responsive metabolic cassette comprised of inositol tris/tetrakisphosphate kinase 1 (ITPK1) and inositol pentakisphosphate 2-kinase (IPK1) buffers diphosphosphoinositol phosphate levels [PDF]
, 2020 Inositol polyphosphates are ubiquitous molecular signals in metazoans, as are their pyrophosphorylated derivatives that bear a so-called 'high-energy' phosphoanhydride bond.
Brearley, Charles +6 more
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Absolute Quantitation of Inositol Pyrophosphates by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry [PDF]
, 2021 Inositol pyrophosphates (PP-InsPs) are an important group of intracellular signaling molecules. Derived from inositol phosphates (InsPs), these molecules feature the presence of at least one energetic pyrophosphate moiety on the myo-inositol ring.
Eisenbeis, VB +3 more
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CHARACTERIZING FERROPTOSIS PATHWAYS IN IN VITRO MOTOR NEURON MODELS [PDF]
, 2021 Ferroptosis is a non-apoptotic regulated form of cell death driven by the toxic accumulation of lipid peroxides and the presence of iron. The mechanism by which ferroptosis operates requires further investigation; here I will discuss the findings ...
Martinez, Alejandra
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The role of inositol pyrophosphates in the regulation of plant stress responses [PDF]
, 2023 Inositol polyphosphates (InsPs) have been described as important messengers in eukaryotic cells. InsPs with one or more diphospho groups are also termed inositol pyrophosphates (PP-InsPs), which gained special attention as potent cellular regulators.
Lange, Esther
core +1 more source
VIH2 Regulates the Synthesis of Inositol Pyrophosphate InsP₈ and Jasmonate-Dependent Defenses in Arabidopsis [PDF]
, 2015 Diphosphorylated inositol polyphosphates, also referred to as inositol pyrophosphates, are important signaling molecules that regulate critical cellular activities in many eukaryotic organisms, such as membrane trafficking, telomere maintenance, ribosome
Azevedo, C +17 more
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Inositol Pyrophosphates and Their Unique Metabolic Complexity: Analysis by Gel Electrophoresis [PDF]
, 2009 Inositol pyrophosphates are a recently characterized cell signalling molecules responsible for the pyrophosphorylation of protein substrates. Though likely involved in a wide range of cellular functions, the study of inositol pyrophosphates has suffered ...
Losito, Oriana +3 more
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Arabidopsis ITPK1 and ITPK2 Have an Evolutionarily Conserved Phytic Acid Kinase Activity [PDF]
, 2019 Diphospho-myo-inositol polyphosphates, also termed inositol pyrophosphates, are molecular messengers containing at least one high-energy phosphoanhydride bond and regulate a wide range of cellular processes in eukaryotes.
Fernandez-Rebollo, N +8 more
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Developing Dictyostelium discoideum as a model to study the synthesis and metabolism of inositol pyrophosphates and inorganic polyphosphate [PDF]
, 2016 Inositol pyrophosphates and inorganic polyphosphate (polyP) represent two of the most phosphate-rich molecules in the cell. However, the synthesis, metabolism and function of these “high-energy” molecules are not well understood.
Livermore, TM
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PPIP5K2 and PCSK1 are Candidate Genetic Contributors to Familial Keratoconus [PDF]
, 2019 Keratoconus (KC) is the most common corneal ectatic disorder affecting >300,000 people in the US. KC normally has its onset in adolescence, progressively worsening through the third to fourth decades of life.
Abu-Amero, Khaled K +24 more
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Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in the enteric nervous system [PDF]
, 2023 Inositol pyrophosphates regulate diverse physiological processes; to better understand their functional roles, assessing their tissue-specific distribution is important.
Fujii, Natsuko +13 more
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