Results 81 to 90 of about 261 (97)

<i>Caenorhabditis elegans</i> inositol hexaphosphate pathways couple to RNA interference and pathogen defense. [PDF]

Proc Natl Acad Sci U S A
Xu W, Sun Y, Breen P, Ruvkun G, Mao K.
europepmc   +1 more source

Extensive protein pyrophosphorylation revealed in human cell lines. [PDF]

Nat Chem Biol
Morgan JAM, Singh A, Kurz L, Nadler-Holly M, Ruwolt M, Ganguli S, Sharma S, Penkert M, Krause E, Liu F, Bhandari R, Fiedler D.   +11 more
europepmc   +1 more source

IPPK-1 and IP6 contribute to ventral nerve cord assembly in C. elegans. [PDF]

Dev Biol
Noblett N, Roenspies T, Kirezi CB, Stubbert C, Flibotte S, Shah PK, Colavita A.   +6 more
europepmc   +1 more source

Activities and genetic interactions of fission yeast Aps1, a Nudix-type inositol pyrophosphatase and inorganic polyphosphatase. [PDF]

mBio
Ghosh S, Sanchez AM, Schwer B, Prucker I, Jork N, Jessen HJ, Shuman S.   +6 more
europepmc   +1 more source

The significance of the 1-kinase/1-phosphatase activities of the PPIP5K family

Advances in Biological Regulation, 2017
The inositol pyrophosphates (diphosphoinositol polyphosphates), which include 1-InsP7, 5-InsP7, and InsP8, are highly 'energetic' signaling molecules that play important roles in many cellular processes, particularly with regards to phosphate and bioenergetic homeostasis. Two classes of kinases synthesize the PP-InsPs: IP6Ks and PPIP5Ks.
Stephen B Shears, Brandi M Baughman, Huanchen Wang   +2 more
exaly   +4 more sources

The wheat VIH2-3B, a functional PPIP5K controls the localization of fasciclin-like arabinogalactan protein

Advances in Biological Regulation
Abstract Inositol pyrophosphates (PP-InsPs) are important signalling molecules that participate in multiple physiological processes across a wide range of eukaryotes. Metabolic pathway kinases (VIP1/VIHs) leading to the production of PP-InsPs are now well characterized in yeast and plants. Previously, the wheat (
Ajay Kumar Pandey
exaly   +4 more sources

PPIP5K

, 2016
Stephen B Shears
exaly   +4 more sources

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An In Vivo Yeast-Based Activity Assay for the PPIP5K Family

Methods in Molecular Biology
The highly conserved eukaryotic PPIP5K family of bifunctional enzymes regulate cellular levels of 1,5-InsP8, a high-energy molecule involved in a multitude of biological processes. Members of this family contain two opposing activities: an N-terminus ATP-grasp kinase domain synthesizing 1,5-InsP8 and a C-terminus pyrophosphatase domain degrading 1,5 ...
Ursula Fleig
exaly   +3 more sources

The PPIP5K Family Member Asp1 Controls Inorganic Polyphosphate Metabolism in S. pombe [PDF]

Journal of Fungi (Basel, Switzerland), 2021
Inorganic polyphosphate (polyP) which is ubiquitously present in both prokaryotic and eukaryotic cells, consists of up to hundreds of orthophosphate residues linked by phosphoanhydride bonds.
Ursula Fleig, Adolfo Saiardi
exaly   +2 more sources

Inositol Pyrophosphate-Controlled Kinetochore Architecture and Mitotic Entry in S. pombe

Journal of Fungi (Basel, Switzerland), 2022
Inositol pyrophosphates (IPPs) comprise a specific class of signaling molecules that regulate central biological processes in eukaryotes. The conserved Vip1/PPIP5K family controls intracellular IP8 levels, the highest phosphorylated form of IPPs present ...
Natascha A Künzel, Ursula Fleig, Dorothea Fiedler   +2 more
exaly   +1 more source