Results 161 to 170 of about 2,889 (188)
<i>S</i>-Palmitoylation in Health and Disease. [PDF]
BiochemistryWong W, Hu M, Isaacson RL.
europepmc +1 more source
Niemann Pick C1 mistargeting disrupts lysosomal cholesterol homeostasis contributing to neurodegeneration in a Batten disease model. [PDF]
Sci AdvAppu AP +8 more
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Seizures in PPT1 Knock-In Mice Are Associated with Inflammatory Activation of Microglia
International Journal of Molecular Sciences, 2022 Infantile neuronal ceroid lipofuscinosis (INCL), the most severe form of neuronal ceroid lipofuscinoses, is caused by mutations in the lysosomal enzyme palmitoyl protein thioesterase 1 (PPT1).
Mingyong Wang, Tong Jia
exaly +4 more sources
GFAP hyperpalmitoylation exacerbates astrogliosis and neurodegenerative pathology in PPT1-deficient mice [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance This study reports that the intermediate filament protein GFAP is modified with protein palmitoylation. Increased GFAP expression and palmitoylation is involved in astrocyte proliferation and astrogliosis. We demonstrate that GFAP palmitoylation is regulated by PPT1, a palmitoylprotein thioesterase linked to a childhood ...
Jian Gao, Yinming Liang, Eryan Kong
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Role of Ppt1 in multiple stress responses in Candida albicans
Science Bulletin, 2014 To study the function of CaPpt1, we deleted PPT1 gene from the Candida albicans genome by sequentially replacing the entire coding region with the selectable markers ARG4 and HIS1. The results showed that the deletion of Ppt1 did not affect the hyphal formation of C.
Wanjie Li, Haitao Wang, Yue Wang
exaly +2 more sources
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Journal of Neuroscience Research, 2000
Infantile neuronal ceroid lipofuscinosis (INCL) is a childhood neurodegenerative disease caused by the selective death of cortical neurons and retinal degeneration, as the result of a palmitoyl protein thioesterase 1 (PPT1) deficiency. Recently, we showed that overexpression of PPT1 protects LA-N-5 human neuroblastoma cells against apoptotic death (Cho
S, Cho, P E, Dawson, G, Dawson
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Infantile neuronal ceroid lipofuscinosis (INCL) is a childhood neurodegenerative disease caused by the selective death of cortical neurons and retinal degeneration, as the result of a palmitoyl protein thioesterase 1 (PPT1) deficiency. Recently, we showed that overexpression of PPT1 protects LA-N-5 human neuroblastoma cells against apoptotic death (Cho
S, Cho, P E, Dawson, G, Dawson
openaire +2 more sources
Progress on lysosomal PPT1-mediated regulation of cellular homeostasis and pathogenesis.
Yi chuan = Hereditas, 2023Palmitoyl protein thioesterase 1(PPT1) is a lysosomal enzyme that catalyzes the protein depalmitoylation. It is considered to play a crucial role in regulating lysosomes, mitochondria and lipid metabolism. PPT1 has been reported to play an important role in the occurrence and progression of diseases, such as neurological diseases and cancers.
Xin-Yi, Zhou +6 more
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Journal of Proteome Research, 2012
Even though protein phosphatases are key regulators of signal transduction, their cellular mechanisms of action are poorly understood. Here, we undertook a large-scale proteomics survey to identify cellular protein targets of a serine/threonine phosphatase.
Schreiber, T. +5 more
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Even though protein phosphatases are key regulators of signal transduction, their cellular mechanisms of action are poorly understood. Here, we undertook a large-scale proteomics survey to identify cellular protein targets of a serine/threonine phosphatase.
Schreiber, T. +5 more
openaire +3 more sources
Phenotypes and fed-batch fermentation of ubiquinone-overproducing fission yeast using ppt1 gene
Journal of Biotechnology, 2007Ubiquinone (UQ), a component of the electron transfer system in many organisms, has been widely used for pharmaceuticals and cosmetics. In this study, we cloned and overexpressed the full-length ppt1 (MTppt1) gene, which encodes p-hydroxybenzoate:polyprenyltransferase and ERppt1 gene, which was modified to be localized on endoplasmic reticulum in ...
Dawei, Zhang +4 more
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