Results 111 to 120 of about 13,975 (182)

Generation of Infectious Prions Amenable to Site-Specific Click Chemistry. [PDF]

ACS Chem Biol
Campbell RG, Iseler JN, Schwind AM, Supattapone S.   +3 more
europepmc   +1 more source

Reassessing the Proposed Creatine–PrP Axis in Endometriosis: Methodological and Mechanistic Considerations

Advanced Science, Volume 13, Issue 44, 7 August 2026.
ABSTRACT The research by Chen et al. (2024) presents an innovative hypothesis linking creatine metabolism to ferroptosis resistance in endometriotic stromal cells via PrP suppression. While conceptually valuable, methodological aspects warrant reflection.
Marco Machado
wiley   +1 more source

A Neuronal Cell Line Model for Studying Camel Prions. [PDF]

Pathogens
Abdulrahman B, Rahimi Aqdam S, Mosca M, Ahmed-Hassan H, Razcon-Echeagaray M, Popa L, Gilch S, Babelhadj B, Vaccari G, Schätzl HM.   +9 more
europepmc   +1 more source

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, Volume 13, Issue 43, 3 August 2026.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

White-tailed deer scavenging community in a chronic wasting disease-endemic region and considerations for prion movement. [PDF]

Sci Rep
Jorge MH, Jorge LA, Jarosinski D, Chandler RB, D'Angelo GJ, Ruder MG, Chamberlain MJ.   +6 more
europepmc   +1 more source

Aptamer‐Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN‐STAT3 Complex and Enables Liquid Biopsy Detection

Advanced Science, Volume 13, Issue 45, 13 August 2026.
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang, Hongyu Wu, Chaojing Zheng, Hao Zhang, Xiaoqiu Wu, Jiaqi Wang, Zewen Chang, Jun Xiang, Yunxiao Liu, Chenkai Zhang, Yuliuming Wang, Hao Jiang, Yuchen Zhong, Jun Luo, Ying Chen, NaNa Zhang, Weiyuan Zhang, Ziming Yuan, ChaoXia Zou, Weihong Tan, Meng Wang, Hanqing Hu, Tao Bing, Guiyu Wang   +23 more
wiley   +1 more source

Prion propagation is controlled by discrete structural regions of PrP rather than overall stability. [PDF]

J Biol Chem
Bhamra SK, Arora P, Liew M, Hosszu LLP, Batchelor M, Clarke AR, Bieschke J, Collinge J, Jat PS.   +8 more
europepmc   +1 more source

Current Challenges of Transcription Compartmentalization Research

Advanced Science, Volume 13, Issue 46, 17 August 2026.
Transcription factors, coactivators, and RNA polymerase II assemble into transcription compartments ranging from small, defined complexes to liquid‐like condensates. This review unifies these seemingly competing descriptions along a single continuum and asks what these compartments have been shown to do, and what they have not, revealing that the most ...
Thomas Quail, Sina Wittmann
wiley   +1 more source

Emerging risks at the vampire bat-prion interface: implications for wildlife, livestock, and public health. [PDF]

J Mammal
Frank LE, Bartz JC, Larsen PA.
europepmc   +1 more source

Reply to “Reassessing the Proposed Creatine–PrP Axis in Endometriosis: Methodological and Mechanistic Considerations”

Advanced Science, Volume 13, Issue 45, 13 August 2026.
ABSTRACT This Correspondence is a formal response to the Comment by Dr. Machado regarding our publication “Creatine Promotes Endometriosis by Inducing Ferroptosis Resistance via Suppression of PrP.” We address several conceptual concerns raised in the Comment and clarify the physiological relevance of creatine concentrations, the methodological ...
Siman Chen, Xiaoqian Ma, Yukai Liu, Zhiqi Zhong, Chunyan Wei, Mingqing Li, Xiaoyong Zhu   +6 more
wiley   +1 more source