Results 141 to 150 of about 13,975 (182)

Neuroprotective Effects of RNS60 in TDP‐43 Pathology‐Associated Amyotrophic Lateral Sclerosis

Muscle &Nerve, Volume 74, Issue 2, Page 463-473, August 2026.
ABSTRACT Introduction TDP‐43 pathology is broadly observed in the cerebral cortex of patients with amyotrophic lateral sclerosis (ALS). RNS60, an experimental treatment for acute ischemic stroke and ALS, enhanced mitochondrial biogenesis and function in other preclinical models.
Danny R. Vesevick, Supurna Ghosh, Andreas Kalmes, P. Hande Ozdinler, Mukesh Gautam   +4 more
wiley   +1 more source

Development of a Procedure for Prion Surveillance in the Laboratory Setting. [PDF]

J Infect Dis
Gorski D, Schauer I, Spicker K, Tupaki-Sreepurna A, Wang F, Soto C, Pritzkow S.   +6 more
europepmc   +1 more source

Damping amyloid‐associated conformational fluctuations in a protein by an engineered diselenide bridge

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Polypeptide cross‐β assembly, characteristic of diverse proteotoxic diseases, defines a general thermodynamic ground state and limits the shelf lives of peptide‐ and protein therapeutics. A model is provided by insulin. Although the hormone contains a predominance of α‐helix, its fibrils exhibit cross‐β reorganization.
Yanwu Yang, Balamurugan Dhayalan, Andreas Ehnbom, Orit Weil‐Ktorza, Norman Metanis, Michael A. Weiss   +5 more
wiley   +1 more source

Membrane-anchored PrPSc is the trigger for prion synaptotoxicity. [PDF]

PLoS Pathog
Gatdula JRP, Mercer RCC, Alepuz Guillen JA, Vultaggio JS, Harris DA.   +4 more
europepmc   +1 more source

Advances in the nanostructure characterization of biological hydrogels formed by the prion‐like domain of EARLY FLOWERING 3

Acta Crystallographica Section D, Volume 82, Issue 8, Page 940-946, August 2026.
In biological systems, hydrogels often arise through liquid–liquid phase separation, where biomolecular condensates can age into gel‐like states. SAXS is a key technique to probe the molecular organization of these samples. This study introduces an in‐vacuum Gel‐Cell for SAXS‐based structural analysis of a biologically derived hydrogel formed by the ...
Stephanie Hutin, Pedro L. O. Filho, Anton M. Popov, Petra Pernot, Chloe Zubieta, Mark D. Tully   +5 more
wiley   +1 more source

Assessing the Conservation Status, Drivers of Threat and Available Occurrence Records of Sub‐Saharan African Freshwater Molluscs: Gaps and Patterns

African Journal of Ecology, Volume 64, Issue 6, August 2026.
ABSTRACT Freshwater molluscs are key bioindicators of ecosystem health, yet their conservation status and data coverage in sub‐Saharan Africa remain poorly understood. Mollusca is the third most evaluated phylum on the IUCN Red List in Africa, with 1394 species assessed (656 freshwater), of which 39.6% are Least Concern and 12% Critically Endangered ...
Marcel Kruger, Dewidine van der Colff, Wynand Malherbe   +2 more
wiley   +1 more source

Modelling human proteostasis and organelle homeostasis disorders in yeast and its application in drug discovery. [PDF]

FEMS Yeast Res
Do AV, Zahra M, Munn AL.
europepmc   +1 more source

Infection control in the brain and the eye

Acta Ophthalmologica, Volume 104, Issue 5, Page e478-e490, August 2026.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

D178N prion protein mutation endows RML prions with new strain properties that do not mimic human genetic prion diseases. [PDF]

Acta Neuropathol
Masone A, Grasso A, Comerio L, Bruno R, Lavigna G, Vanni I, D'Agostino C, Orrù CD, Caughey B, Altmeppen HC, Castilla J, Giaccone G, Tagliavini F, Di Bari MA, Nonno R, Chiesa R.   +15 more
europepmc   +1 more source

Concurrent Hashimoto's Encephalopathy and Papillary Thyroid Carcinoma: A Case Report

Clinical and Experimental Neuroimmunology, Volume 17, Issue 3, August 2026.
ABSTRACT Background Hashimoto's encephalopathy (HE) is a rare steroid‐responsive autoimmune syndrome. Although HE is associated with anti‐thyroid antibodies, its concurrence with malignant thyroid tumors has rarely been described and its clinical implications remain poorly understood.
Ryo Hara, Toshiyuki Kakumoto, Anna Suzuki, Satoshi Yamashita, Takayoshi Niwa, Kanako Hayashi, Arisa Morizono, Ayaka Sato, Masahiko Tanabe, Noritaka Kudo, Masashi Hamada, Wataru Satake, Tatsushi Toda   +12 more
wiley   +1 more source