Results 31 to 40 of about 1,577,570 (335)

Exposing the evidence gap for complementary and alternative medicine to be integrated into science-based medicine. [PDF]

, 2011
When people who advocate integrating conventional science-based medicine with complementary and alternative medicine (CAM) are confronted with the lack of evidence to support CAM they counter by calling for more research, diverting attention to the ...
Hopayian, K, Power, M.
core   +1 more source

A comparison of approaches for adjudicating outcomes in clinical trials

Trials, 2017
Background Incorrect classification of outcomes in clinical trials can lead to biased estimates of treatment effect and reduced power. Ensuring appropriate adjudication methods to minimize outcome misclassification is therefore essential. While there are
Brennan C. Kahan, Brian Feagan, Vipul Jairath   +2 more
doaj   +1 more source

What Is a Pragmatic Clinical Trial? [PDF]

Journal of Investigative Dermatology, 2015
Pragmatic trials Pragmatic clinical trials seek to determine the effectiveness of an intervention in a real-world setting to inform clinical decision making (Roland and Torgerson, 1998). Researchers designing pragmatic trials take particular care to ensure that the study population is as similar as possible to the population on which the intervention ...
Williams, Hywel C., Burden-Teh, Esther, Nunn, Andrew J.   +2 more
openaire   +2 more sources

An algorithm for diagnosing IgE-mediated food allergy in study participants who do not undergo food challenge. [PDF]

, 2020
BACKGROUND: Food allergy diagnosis in clinical studies can be challenging. Oral food challenges (OFC) are time-consuming, carry some risk and may, therefore, not be acceptable to all study participants.
Batt, R, Boyle, RJ, Bradshaw, LE, Chalmers, JR, Haines, RH, Jay, N, Kelleher, MM, Montgomery, AA, Perkin, MR, Williams, HC   +9 more
core   +2 more sources

Electronic health records to facilitate clinical research [PDF]

, 2016
Electronic health records (EHRs) provide opportunities to enhance patient care, embed performance measures in clinical practice, and facilitate clinical research. Concerns have been raised about the increasing recruitment challenges in trials, burdensome
Blomster, Juuso I., Cowie, Martin R., Curtis, Lesley H., Duclaux, Sylvie, Ford, Ian, Fritz, Fleur, Goldman, Samantha, Janmohamed, Salim, Kreuzer, Jörg, Leenay, Mark, Michel, Alexander, Ong, Seleen, Pell, Jill P., Southworth, Mary Ross, Stough, Wendy Gattis, Thoenes, Martin, Zalewski, Andrew, Zannad, Faiez   +17 more
core   +2 more sources

The Effectiveness of Alcohol Screening and Brief Intervention in Emergency Departments: A Multicentre Pragmatic Cluster Randomized Controlled Trial [PDF]

, 2014
BACKGROUND: Alcohol misuse is common in people attending emergency departments (EDs) and there is some evidence of efficacy of alcohol screening and brief interventions (SBI).
A Moyer, A Trinks, Adenekan Oyefeso, AW Dent, Bernard Le Foll, C Drummond, CA Field, Christine Godfrey, CJ Cherpitel, Colin Drummond, D Newbury-Birch, DC Drummond, Dorothy Newbury-Birch, E Kaner, EFS Kaner, Eileen Kaner, Eilish Gilvarry, FC Blow, G D'Onofrio, G D'Onofrio, G D'Onofrio, J Peters, J Rehm, J Wittes, J-B Daeppen, JA Bernstein, Jonathan Shepherd, Judy Myles, Katherine Perryman, MA Walton, Martin Bland, Mike Crawford, MJ Crawford, MT French, Nick Heather, Paolo Deluca, Paul Cassidy, R Patton, RM Cunningham, RM Cunningham, Robert Patton, Robin Touquet, Ruth McGovern, S Bazargan-Hejazi, S Coulton, S Waller, S Williams, Simon Coulton, Steve Parrott, Tom Phillips, Veronica Dale   +50 more
core   +17 more sources

Sequence balance minimisation: minimising with unequal treatment allocations

Trials, 2017
Background Minimisation ensures excellent balance between groups for several prognostic factors, even in small samples. However, its use with unequal allocation ratios has been problematic.
Vichithranie W. Madurasinghe
doaj   +1 more source

Stakeholder perspectives regarding pragmatic clinical trial collateral findings

Learning Health Systems, 2021
Context Pragmatic clinical trials (PCTs), which are becoming widespread since they are relatively inexpensive and offer important benefits for healthcare decision‐making, can also present practical, ethical, and legal challenges.
Stephanie R. Morain, Debra J. H. Mathews, Kevin Weinfurt, Elizabeth May, Juli M. Bollinger, Gail Geller, Jeremy Sugarman   +6 more
doaj   +1 more source

Outcome pre-specification requires sufficient detail to guard against outcome switching in clinical trials: a case study

Trials, 2018
Background Pre-specification of outcomes is an important tool to guard against outcome switching in clinical trials. However, if the outcome is not sufficiently clearly defined, then different definitions could be applied and analysed, with only the most
Brennan C. Kahan, Vipul Jairath
doaj   +1 more source

Study within a trial of electronic versus paper-based Patient-Reported oUtcomes CollEction (SPRUCE): study protocol for a partially randomised patient preference study

BMJ Open, 2023
Introduction Patient-reported outcomes (PRO) are currently collected from trial participants using paper questionnaires by the Clinical Trials and Statistics Unit at The Institute of Cancer Research (ICR-CTSU).
Rebecca Lewis, Emma Hall, Jacqui Gath, Elizabeth Hill, Lara Philipps, Stephanie Foster, Deborah Gardiner, Alexa Gillman, Joanne Haviland, Diana King, Georgina Manning, Morgaine Stiles   +11 more
doaj   +1 more source