Results 41 to 50 of about 1,577,570 (335)

Ethics and practice of trials within cohorts: An emerging pragmatic trial design [PDF]

, 2018
BACKGROUND: With increasing emphasis on pragmatic trials, new randomized clinical trial designs are being proposed to enhance the "real world" nature of the data generated.
Clare Relton, James Flory, Kim S, Olsen L, Scott YH Kim, Van der Velden JM, Vickers AJ   +6 more
core   +1 more source

A comparison of methods to adjust for continuous covariates in the analysis of randomised trials

BMC Medical Research Methodology, 2016
Background Although covariate adjustment in the analysis of randomised trials can be beneficial, adjustment for continuous covariates is complicated by the fact that the association between covariate and outcome must be specified.
Brennan C. Kahan, Helen Rushton, Tim P. Morris, Rhian M. Daniel   +3 more
doaj   +1 more source

Clinical- and cost-effectiveness of a technology-supported and solution-focused intervention (DIALOG+) in treatment of patients with chronic depression—study protocol for a multi-site, cluster randomised controlled trial [TACK]

Trials, 2022
Background Many with an acute depressive disorder go on to develop chronic depression, despite ongoing care. There are few specifically designed interventions to treat chronic depression.
Philip McNamee, Aleksandra Matanov, Lauren Jerome, Sally Kerry, Neil Walker, Yan Feng, Andrew Molodynski, Shonagh Scott, Latha Guruvaiah, Sue Collinson, Rose McCabe, John Geddes, Stefan Priebe, Victoria Bird   +13 more
doaj   +1 more source

Integrating evidence for managing asthma in patients who smoke [PDF]

, 2014
Peer reviewedPublisher ...
Bjermer, Leif, Chisholm, Alison, Popov, Todor A, Price, David   +3 more
core   +1 more source

The iBRA (implant breast reconstruction evaluation) study: protocol for a prospective multi-centre cohort study to inform the feasibility, design and conduct of a pragmatic randomised clinical trial comparing new techniques of implant-based breast reconstruction. [PDF]

, 2016
BACKGROUND: Implant-based breast reconstruction (IBBR) is the most commonly performed reconstructive procedure in the UK. The introduction of techniques to augment the subpectoral pocket has revolutionised the procedure, but there is a lack of high ...
Barnes, NL, Blazeby, JM, Branford, OA, Breast Reconstruction Research Collaborative, Conroy, EJ, Cutress, RI, Gardiner, MD, Holcombe, C, Jain, A, McEvoy, K, Mills, N, Mylvaganam, S, Potter, S, Skillman, JM, Teasdale, EM, Thrush, S, Whisker, LJ, Williamson, PR   +17 more
core   +5 more sources

TREC-Rio trial: a randomised controlled trial for rapid tranquillisation for agitated patients in emergency psychiatric rooms [ISRCTN44153243] [PDF]

, 2002
Agitated or violent patients constitute 10% of all emergency psychiatric treatment. Management guidelines, the preferred treatment of clinicians and clinical practice all differ.
A Jablensky, B Thornley, CB Joy, Clive E Adams, E Coutinho, Evandro SF Coutinho, Expert Consensus Guideline Group, F Moritz, G Huf, Gisele Huf, HI Kaplan, J Ludbrook, JG Cunnane, LS Pilowsky, M Fenton, M Hotopf, M Wyant, P Armitage, RL Binder, The Royal College of Psychiatrists, VW Berger, Z Atakan   +21 more
core   +3 more sources

Stakeholder Engagement in Pragmatic Clinical Trials: Emphasizing Relationships to Improve Pain Management Delivery and Outcomes.

Pain medicine (Malden, Mass.), 2020
BACKGROUND The NIH-DOD-VA Pain Management Collaboratory (PMC) supports 11 pragmatic clinical trials (PCTs) on nonpharmacological approaches to management of pain and co-occurring conditions in U.S. military and veteran health organizations.
L. Bastian, Steven P. Cohen, Lily Katsovich, W. Becker, Brad R Brummett, Diana J. Burgess, Andrea E Crunkhorn, Lauren M. Denneson, Joseph W. Frank, C. Goertz, B. Ilfeld, K. Kanzler, Akshaya Krishnaswamy, K. LaChappelle, Steve Martino, K. Mattocks, C. McGeary, Thomas E Reznik, D. Rhon, S. Salsbury, K. Seal, Alicia M. Semiatin, Marlena H. Shin, C. Simon, D. Teyhen, Kara A Zamora, R. Kerns   +26 more
semanticscholar   +1 more source

Contamination in complex healthcare trials:the falls in care homes (FinCH) study experience [PDF]

, 2020
BACKGROUND: Trials are at risk of contamination bias which can occur when participants in the control group are inadvertently exposed to the intervention.
Allen, F, Darby, J, Fox, C, Gordon, A L, Horne, J C, Leighton, P, Logan, P A, Robinson, K, Sims, Erika   +8 more
core   +1 more source

Data monitoring committees for pragmatic clinical trials [PDF]

Clinical Trials, 2015
In any clinical trial, it is essential to monitor the accumulating data to be sure that the trial continues to be safe for participants and that the trial is being conducted properly. Data monitoring committees, independent expert panels who undertake regular reviews of the data as the trial progresses, serve an important role in safeguarding the ...
Ellenberg, Susan S, Culbertson, Richard, Gillen, Daniel L, Goodman, Steven, Schrandt, Suzanne, Zirkle, Maryan   +5 more
openaire   +4 more sources

Building a National Program for Pilot Studies of Embedded Pragmatic Clinical Trials in Dementia Care

Journal of The American Geriatrics Society, 2020
Sixteen million caregivers currently provide care to more than 5 million persons living with dementia (PLWD) in the United States. Although this population is growing and highly complex, evidence‐based management remains poorly integrated within ...
A. Brody, D. Barnes, J. Chodosh, J. Galvin, K. Hepburn, A. Troxel, Kimberly Hom, E. McCarthy, K. Unroe   +8 more
semanticscholar   +1 more source