Organophosphate Poisoning: Insights From a Case Report of Acute Cholinergic Syndrome [PDF]
Clinical Case ReportsOrganophosphate (OP) pesticides are widely used in agriculture and can cause acute cholinergic toxicity by inhibiting the enzyme acetylcholinesterase, leading to an accumulation of acetylcholine.
Gudisa Bereda
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Atrial Fibrillation Following Acute Malathion Ingestion: A Rare Cardiac Manifestation of Organophosphate Poisoning [PDF]
Clinical Case ReportsOrganophosphate poisoning can precipitate acute atrial fibrillation even in previously healthy individuals. This first documented case from Pakistan of Malathion‐induced atrial fibrillation emphasizes the need for early recognition, continuous cardiac ...
Qurat ul Ain +3 more
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Pralidoxime in organophosphorus poisoning
Journal of Nepal Medical Association, 2010 INTRODUCTION: Pralidoxime are enzyme reactivator that are known to reactivate the phosphorylated acetylcholinesterase by binding to the organophosphorus molecule.
N R Simkhada, KK Kafle, PN Prasad
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Oxime and atropine failure to prevent intermediate syndrome development in acute organophosphate poisoning [PDF]
Vojnosanitetski Pregled, 2013 Introduction. Intermediate syndrome (IMS) was described a few decades ago, however, there is still a controversy regarding its exact etiology, risk factors, diagnostic parameters and required therapy.
Vučinić Slavica +3 more
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Case Report: 2-PAM or not 2-PAM [PDF]
Clinical Practice and Cases in Emergency MedicineIntroduction: Organophosphates (OP) are used as pest control agents worldwide and have been seen in accidental and intentional poisonings. Case Report: A patient presented after intentional ingestion of the OP Orthene (50% acephate).
Madelyn Huttner +3 more
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Stability of Multicomponent Antidote Parenteral Formulations for Autoinjectors against Chemical War Agents (Neurotoxics) [PDF]
PharmaceuticsCombinations of different drugs are formulated in autoinjectors for parenteral administration against neurotoxic war agents. In this work, the effects on the chemical stability of the following three variables were studied: (i) type of drug combination ...
María José Rodríguez Fernández +4 more
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Pralidoxime improves the hemodynamics and survival of rats with peritonitis-induced sepsis.
PLoS ONE, 2021 Several studies have suggested that sympathetic overstimulation causes deleterious effects in septic shock. A previous study suggested that pralidoxime exerted a pressor effect through a mechanism unrelated to the sympathetic nervous system; this effect ...
Najmiddin Mamadjonov +8 more
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Effect of pralidoxime on coronary perfusion pressure during cardiopulmonary resuscitation in a pig model [PDF]
Clinical and Experimental Emergency Medicine, 2019 Objective Pralidoxime is widely used for the treatment of organophosphate poisoning. Multiple studies have reported its vasoconstrictive property, which may facilitate the restoration of spontaneous circulation (ROSC) after cardiac arrest by increasing ...
Yong Hun Jung +7 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background We previously reported that pralidoxime facilitated restoration of spontaneous circulation by potentiating the pressor effect of epinephrine. We determined the optimal dose of pralidoxime during cardiopulmonary resuscitation and evaluated the ...
Yong Hun Jung +7 more
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Evaluation of Pralidoxime Use in an Iranian Teaching Referral Hospital [PDF]
Pharmaceutical Sciences, 2018 Background: Organophosphorus (OP) poisonings, a common source of pesticide poisoning, are an important cause of morbidity and mortality in the developing countries.
Ali Banagozar Mohammadi +4 more
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