Results 51 to 60 of about 3,544 (200)

Role of the Calcium Plateau in the Neuronal Injury and Behavioral Morbidities Following Organophosphate Intoxication [PDF]

, 2016
Organophosphate (OP) chemicals include nerve agents and pesticides, and there is a growing concern of OP based chemical attacks against civilians. Current antidotes are essential in limiting immediate mortality associated with OP exposure.
Battaglia F.P., Campbell S., Dingeman A., Filbert M., Karki P., Konradsen F., Moorcraft P., Than K., Yamashita M.   +8 more
core   +2 more sources

Nanometric MIL-125-NH2 Metal–Organic Framework as a Potential Nerve Agent Antidote Carrier

Nanomaterials, 2017
The three-dimensional (3D) microporous titanium aminoterephthalate MIL-125-NH2 (MIL: Material of Institut Lavoisier) was successfully isolated as monodispersed nanoparticles, which are compatible with intravenous administration, by using a simple, safe ...
Sérgio M. F. Vilela, Pablo Salcedo-Abraira, Isabelle Colinet, Fabrice Salles, Martijn C. de Koning, Marloes J. A. Joosen, Christian Serre, Patricia Horcajada   +7 more
doaj   +1 more source

Survival pattern in patients with acute organophosphate poisoning on mechanical ventilation: A retrospective intensive care unit-based study in a tertiary care teaching hospital

Indian Journal of Anaesthesia, 2014
Background and Aims: Organophosphorus (OP) compound poisoning is one of the most common poisonings in India. The aim of the study was to study the outcomes and predictors of mortality in patients with acute OP poisoning requiring mechanical ventilation ...
Syed M Ahmed, Bikramjit Das, Abu Nadeem, Rajiv K Samal   +3 more
doaj   +1 more source

The Subcutaneous Injection of Organophosphate: A Case Report

International Journal of Medical Toxicology and Forensic Medicine, 2021
Organophosphate (OP) poisoning is prevalent in developing countries. Toxicity occurs by voluntary injection, inhalation, and absorption. Self-injection is rare.
Shafeajafar Zoofaghari, Afshar Fazeli Dehkordi, Kourosh Nemati, Mozhdeh Hashemzadeh, Arman Otroshi   +4 more
doaj   +1 more source

Perampanel as a second‐line therapy to midazolam reduces soman‐induced status epilepticus and neurodegeneration in rats

Epilepsia Open, Volume 10, Issue 4, Page 1187-1198, August 2025.
Abstract Objective A benzodiazepine (diazepam or midazolam) is one of the current standards of care therapies to effectively terminate organophosphorus nerve agent‐induced status epilepticus when administered shortly after onset. Preclinical studies showed that benzodiazepines were less effective in stopping status epilepticus when treatment was ...
Hailey G. Steier, Caroline R. Schultz, Jerome Niquet, Donna A. Nguyen, Michael F. Stone, Abiel K. Biney, Marcio de Araujo Furtado, Claude G. Wasterlain, Lucille A. Lumley   +8 more
wiley   +1 more source

Unveiling Novel Chaotropic Chromatography Method for Determination of Pralidoxime in Nerve Agent Antidote Autoinjectors

Separations
Pralidoxime chloride, a highly hydrophilic antidote, cannot be effectively separated by reverse-phase high-performance liquid chromatography (RP-HPLC), unless the mobile-phase composition is varied.
Bohyun Shin, Hyung-seung Kim, Ji-Youn Lee, Sumin Seo, Cho Hee Jeong, Eunbin Bae, Jiyu Kim, Hyojeong Lee, Donghee Lee, Dong-Kyu Lee, Sang Beom Han   +10 more
doaj   +1 more source

1,3–Bis(2–hydroxyiminomethylpyridinium) Propane as the Potential Reactivator of the Acetylcholinesterase Inhibited by Nerve Agents

Acta Medica, 2004
The oxime K005 [1,3–bis(2–hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX was tested.
Kamil Kuča, Vlastimil Dohnal
doaj   +1 more source

Acute and persistent changes in neural oscillatory activity predict development of epilepsy following acute organophosphate intoxication in adult rats

Epilepsia, Volume 66, Issue 4, Page 1329-1342, April 2025.
Abstract Objective Acute organophosphate (OP) intoxication affects a significant number of individuals worldwide. Those who survive OP‐induced cholinergic crisis, which includes status epilepticus, often develop neurological morbidities. Here, we provide a rigorous characterization of the acute and delayed electrophysiological responses to OP ...
Jeremy A. MacMahon, Peter M. Andrew, Ali Izadi, Donald A. Bruun, Naomi H. Saito, Daniel J. Tancredi, Amy Brooks‐Kayal, Pamela J. Lein, Gene G. Gurkoff   +8 more
wiley   +1 more source

Reactivation Potency of New Group of Acetylcholinesterase Reactivators and Their Comparison with Currently Available Oximes

Acta Medica, 2006
In this work, in vitro potency of novel serie of monoquaternary pyridinium oximes to reactivate cyclosarin-inhibited acetylcholinesterase (AChE) was tested.
Kamil Kuča, Jan Pícha, Daniel Jun
doaj   +1 more source

Clay-biosurfactant materials as functional drug delivery systems: Slowing down effect in the in vitro release of cinnamic acid [PDF]

, 2017
The main objectives of the present paper were the preparation and characterization of new surfactant-modified clays and the evaluation of their potential applicability as drug delivery systems for the oral administration of the cinnamic acid (CA) drug ...
Calabrese, I, Gelardi, G, Liveri, M.L.T, Merli, M, Sciascia, L.   +4 more
core   +1 more source