Results 71 to 80 of about 3,544 (200)

An Efficient Synthesis of Pyridoxal Oxime Derivatives under Microwave Irradiation [PDF]

, 2014
Quaternary salts of pyridoxal oxime have been synthesized by the quaternization of pyridoxal oxime with substituted phenacyl bromides using microwave heating.
Bušić, Valentina, Cetina, Mario, Gašo-Sokač, Dajana, Jukić, Marijana   +3 more
core   +4 more sources

Supramolecular Approaches to the Detoxification of Nerve Agents

Israel Journal of Chemistry, Volume 64, Issue 6-7, July 2024.
Abstract A promising, but not yet practiced, approach to the treatment of neurotoxic organophosphate poisoning is the administration of a scavenger that rapidly deactivates the nerve agent before it can exert its toxic effects. The detoxification rates required for successful use of this therapy can currently only be achieved with enzymes, but ...
Stefan Kubik
wiley   +1 more source

Nicotine Replacement Combined with a Novel Compound (ProBAN) for Smoking Cessation: A Pilot Study

Canadian Respiratory Journal, 2001
BACKGROUND: Smoking cessation rates with available pharmacological therapies remain suboptimal. Anecdotal observations with a combination of sublingual pralidoxime and ipratropium (ProBAN) suggested that these agents in combination with nicotine gum ...
Richard Leigh, Norman M Viner, Gerard Cox, Jeffrey W Balon, Douglas MC Wilson, Denise O’Shaughnessy, Corinne Walker, Gerry Brosky, Malcolm R Sears   +8 more
doaj   +1 more source

Accidental organophosphate poisoning: A case series of 2 pediatric coumaphos exposures

Journal of the American College of Emergency Physicians Open, 2022
Introduction Pediatric organophosphate insecticide poisonings are rare in the United States, and life‐threatening toxicity is rarely seen. We report 2 accidental ingestions of the organophosphate insecticide coumaphos that resulted in life‐threatening ...
Justin A. Seltzer, Sarah Friedland, Nathan A. Friedman, Garret A. Winkler, Emily Foreman, Yousef Al Mubarak, Brent Buccine, Branden Engorn, Allyson Kreshak, Alicia Minns, Christian A. Tomaszewski, Daniel R. Lasoff, Richard F. Clark   +12 more
doaj   +1 more source

Synthesis and disinfection effect of the pyridine-4-aldoxime based salts [PDF]

, 2015
PubMed ID: 25719739A set of new quaternary ammonium compounds based on pyridine-4-aldoxime was synthesized, characterized with analytical data (NMR, EA, HPLC, MS) and tested for in vitro antimicrobial activity (antibacterial, antifungal) and cytotoxicity.
Doležal, Martin, Doležal, Rafael, Kuča, Kamil, Maliňák, David, Marek, Jan, Pasdiorová, Markéta, Soukup, Ondřej   +6 more
core   +3 more sources

Sublingual administration of atropine eye drops for treating organophosphorus poisoning

Clinical Case Reports, Volume 12, Issue 5, May 2024.
Key Clinical Message An 89‐year‐old patient with fenitrothion toxicity received sublingual atropine eye drops, reducing the intravenous atropine requirement. This alternative method enabled rapid rehabilitation, and he walked unaided, leading to discharge.
Ichiro Hirayama, Yoshito Kamijo, Minaho Nonaka, Tetsuhiro Yano, Mitsuru Ishii, Yoshiteru Tominaga   +5 more
wiley   +1 more source

Management of Treatment and Prevention of Acute OP Pesticide Poisoning by Medical Informatics, Telemedicine and Nanomedicine [PDF]

, 2013
Acute organophosphorous pesticide (OP) poisoning kills a lot of people each year. Treatment of acute OP poisoning is of very difficult task and is a time taking event.
Anurag Singh Chauhan, Ganesh Chandra Sahoo, Krishna Pandey, Kumar Gaurav, Manas Ranjan Dikhit, Md. Yousuf Ansari, Mukta Rani, Naresh Kumar Sinha, Pradeep Das, Rishikesh Kumar, Roshan Kamal Topno, Sindhuprava Rana, Vahab Ali, Vidyananda Ravi Das   +13 more
core  

Colorimetric Detection of Warfare Gases by Polydiacetylenes Toward Equipment‐Free Detection [PDF]

, 2012
Rationally designed polydiacetylene (PDA) molecules have been developed for rapid, selective, sensitive, and convenient colorimetric detection of organophosphate (OP) nerve agents, a mass destruction weapon. Oxime (OX) functionality was incorporated into
Ahn, Bajgar, Brodeur, Cadwell, Carpick, Carpick, Chance, Dale, Dale, Harris, Joshi, Kim, Kolusheva, Lee, Lee, Lee, Lee, Lee, Leikin, Meir, Milatovic, Oh, Olmsted, Pang, Peng, Reppy, Seo, Smith, Subramaniam, Tashiro, Terrier, Yang, Yoon, Zhang   +33 more
core   +1 more source

Disentangling the formation, mechanism, and evolvement of the covalent methanesulfonyl fluoride acetylcholinesterase adduct: Insights into an aged‐like inactive complex susceptible to reactivation by a combination of nucleophiles

Protein Science, Volume 33, Issue 5, May 2024.
Abstract Chemical warfare nerve agents and pesticides, known as organophosphorus compounds inactivate cholinesterases (ChEs) by phosphorylating the serine hydroxyl group located at the active site of ChEs. Over the course of time, phosphorylation is followed by loss of an organophosphate‐leaving group and the bond with ChEs becomes irreversible, a ...
Jure Stojan, Alessandro Pesaresi, Anže Meden, Doriano Lamba   +3 more
wiley   +1 more source

The Influence of the Time of Antidotal Treatment Administration on Its Effectiveness Against Tabun-Induced Poisoning in Mice

Acta Medica, 2004
Summary: 1. The influence of the time of administration of antidotal treatment consisting of anticholinergic drug (atropine) and oxime (pralidoxime, obidoxime, HI-6 or trimedoxime) on its effectiveness to eliminate tabun-induced lethal effects was ...
Jiří Kassa
doaj   +1 more source