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Prasugrel hydrochloride for the treatment of acute coronary syndromes
Expert Opinion on Pharmacotherapy, 2015 P2Y12 receptor antagonists, by inhibiting platelet activation and subsequent aggregation, are critical to prevent ischemic event recurrence after an acute coronary syndrome (ACS). Prasugrel is a third-generation thienopyridine whose metabolites target the P2Y12 receptor.
Thibault, Lhermusier, Ron, Waksman
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The Degradation Chemistry of Prasugrel Hydrochloride: Part 1—Drug Substance
Journal of Pharmaceutical Sciences, 2019Prasugrel hydrochloride is the active ingredient in Effient™, a thienopyridine platelet inhibitor. An extensive study of the degradation chemistry of prasugrel hydrochloride (LY640315 hydrochloride) has been carried out on the drug substance (part I) and on the drug product (part II, future article) using a multidimensional approach including ...
Steven W Baertschi
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Concomitant Polymorphism of Prasugrel Hydrochloride in Reactive Crystallization
Industrial & Engineering Chemistry Research, 2013Concomitant polymorphism of prasugrel hydrochloride was investigated in reactive batch crystallization experiments at 20 and 40 °C.
Wei Du, Qiuxiang Yin, Ying Bao
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Journal of Pharmaceutical Sciences, 2019
Prasugrel hydrochloride (PHCl) undergoes salt disproportionation, and the resulting prasugrel free base (PFB) may lead to the poor in vitro and or in vivo performance of the drug product. The aim of the present work was to develop univariate and multivariate models based on X-ray powder diffraction to quantify the salt and base in the powder and tablet
Sathish Dharani +2 more
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Prasugrel hydrochloride (PHCl) undergoes salt disproportionation, and the resulting prasugrel free base (PFB) may lead to the poor in vitro and or in vivo performance of the drug product. The aim of the present work was to develop univariate and multivariate models based on X-ray powder diffraction to quantify the salt and base in the powder and tablet
Sathish Dharani +2 more
exaly +3 more sources
Research Journal of Pharmacy and Technology, 2018 The construction and performance characteristics of Prasugrel hydrochloride (PRS) selective electrodes were developed. Electrodes were based on the incorporation of PRS with pairing agents, Ammonium Molybdate (MOL) and Nessler reagent (NES). The electrodes displayed a Nernstian response with a mean calibration graphs slopes of 59.21, 27.57 mv.decade-1 ...
Amir Alhaj Sakur +3 more
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Journal of Pharmaceutical and Biomedical Analysis, 2015
A fast and selective capillary electrophoresis method was developed and validated for the simultaneous determination of the hydrochloride and acetic acid content in prasugrel hydrochloride. Because of the poor chromophore, the indirect detection was chosen.
Wioleta Maruszak, Marcin Cybulski
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A fast and selective capillary electrophoresis method was developed and validated for the simultaneous determination of the hydrochloride and acetic acid content in prasugrel hydrochloride. Because of the poor chromophore, the indirect detection was chosen.
Wioleta Maruszak, Marcin Cybulski
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Effects of Solvent on Polymorph Formation and Nucleation of Prasugrel Hydrochloride
Crystal Growth and Design, 2014Three intrinsic properties of solvent were used to evaluate the effects of solvent on polymorph formation of prasugrel hydrochloride. In situ Raman spectroscopy, FTIR, and powder X-ray diffraction were used to characterize two solvent-free polymorphs and five solvates of prasugrel hydrochloride, the two of which were reported for the first time ...
Wei Du, Qiuxiang Yin, Junbo Gong
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Journal of Liquid Chromatography and Related Technologies, 2012
A simple, sensitive, and reproducible gradient reverse-phase ultra-performance liquid chromatographic (UPLC) method was developed for the quantitative determination of Prasugrel and all possible process-related impurities (positional isomers, degradants and byproducts) at the level of 0.5–2.0 µg mL−1.
K Mukkanti, M V Suryanarayana
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A simple, sensitive, and reproducible gradient reverse-phase ultra-performance liquid chromatographic (UPLC) method was developed for the quantitative determination of Prasugrel and all possible process-related impurities (positional isomers, degradants and byproducts) at the level of 0.5–2.0 µg mL−1.
K Mukkanti, M V Suryanarayana
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ChemInform Abstract: An Improvement to the Preparation of Prasugrel Hydrochloride (I).
ChemInform, 2013 Wenhua Ou +4 more
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Drug eruption due to prasugrel hydrochloride: A case report and mini‐review
The Journal of Dermatology, 2019 Midori Kawasaki‐Nagano +6 more
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