Results 121 to 130 of about 1,084 (158)

Prehospital crushed versus integral prasugrel loading dose in STEMI patients with a large myocardial area. [PDF]

EuroIntervention
Wilschut JM, Vogel RF, Elscot JJ, Delewi R, Lemmert ME, van der Waarden NWPL, Nuis RJ, Paradies V, Alexopoulos D, Zijlstra F, Montalescot G, Angiolillo DJ, Krucoff MW, Smits PC, Vlachojannis GJ, Van Mieghem NM, Diletti R.   +16 more
europepmc   +1 more source

Giant Aneurysm in the V1 Segment of Vertebral Artery: A Case Report and Literature Review. [PDF]

NMC Case Rep J
Kushino K, Mori K, Tamase A, Fukui I, Fushimi S, Nakano T, Kojima M, Yamada R, Taguchi H, Nomura M.   +9 more
europepmc   +1 more source

Potent P2Y₁₂ inhibitors in patients with acute myocardial infarction and cardiogenic shock. [PDF]

Crit Care
Jo J, Lee SH, Joh HS, Kim HK, Kim JH, Hong YJ, Ahn YK, Jeong MH, Hur SH, Kim DI, Chang K, Park HS, Bae JW, Jeong JO, Park YH, Yun KH, Yoon CH, Kim Y, Hwang JY, Kim HS, Kwon W, Shin D, Ha J, Kim CH, Choi KH, Park TK, Yang JH, Song YB, Hahn JY, Choi SH, Gwon HC, Lee JM, KAMIR Investigators.   +32 more
europepmc   +1 more source

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Prasugrel Hydrochloride

Profiles of Drug Substances, Excipients and Related Methodology, 2015
A comprehensive profile of prasugrel HCl is reported herein with 158 references. A full description including nomenclature, formulae, elemental analysis, and appearance is included. Methods of preparation for prasugrel HCl, its intermediates, and derivatives are fully discussed.
Mahmoud M H Al Omari, Nidal A Qinna, Khaldoun A Al-Sou'Od   +2 more
exaly   +3 more sources

The Degradation Chemistry of Prasugrel Hydrochloride: Part 1—Drug Substance

Journal of Pharmaceutical Sciences, 2019
Prasugrel hydrochloride is the active ingredient in Effient™, a thienopyridine platelet inhibitor. An extensive study of the degradation chemistry of prasugrel hydrochloride (LY640315 hydrochloride) has been carried out on the drug substance (part I) and on the drug product (part II, future article) using a multidimensional approach including ...
Steven W Baertschi
exaly   +3 more sources

Concomitant Polymorphism of Prasugrel Hydrochloride in Reactive Crystallization

Industrial & Engineering Chemistry Research, 2013
Concomitant polymorphism of prasugrel hydrochloride was investigated in reactive batch crystallization experiments at 20 and 40 °C.
Wei Du, Qiuxiang Yin, Ying Bao
exaly   +2 more sources

Prasugrel hydrochloride for the treatment of acute coronary syndrome patients

Expert Review of Cardiovascular Therapy, 2016
Dual antiplatelet therapy (DAPT) with aspirin combined with either a thienopyridine (clopidogrel or prasugrel) or acyclopentyl-triazolo-pyrimidine (ticagrelor) plays a vital role in the management of acute coronary syndrome (ACS) especially in those undergoing percutaneous coronary intervention (PCI) but even those being managed medically ...
Ashan Gunarathne, Anthony H Gershlick
exaly   +3 more sources

Univariate and Multivariate Models for Determination of Prasugrel Base in the Formulation of Prasugrel Hydrochloride Using XRPD Method

Journal of Pharmaceutical Sciences, 2019
Prasugrel hydrochloride (PHCl) undergoes salt disproportionation, and the resulting prasugrel free base (PFB) may lead to the poor in vitro and or in vivo performance of the drug product. The aim of the present work was to develop univariate and multivariate models based on X-ray powder diffraction to quantify the salt and base in the powder and tablet
Sathish Dharani, Sogra F Barakh Ali, Mansoor A Khan   +2 more
exaly   +3 more sources

Relative bioavailability of prasugrel free base in comparison to prasugrel hydrochloride in the presence and in the absence of a proton pump inhibitor

Arzneimittelforschung, 2011
Prasugrel (CAS 150322-43-3), an inhibitor of platelet activation and aggregation, is indicated to reduce the rate of thrombotic cardiovascular events in patients with acute coronary syndrome. If a proton pump inhibitor is co-administered with prasugrel, a pH dependent salt-to-base conversion rate of prasugrel could become clinically meaningful.
Dan, Seiler, Karlheinz, Doser, Isam, Salem   +2 more
exaly   +3 more sources