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An overview of the utility of prasugrel hydrochloride as a treatment option for ischemic stroke
Expert Review of Neurotherapeutics, 2023Prasugrel, a potent P2Y12 receptor inhibitor, is not currently recommended in patients with stroke due to a higher rate of recurrent stroke. Prasugrel was associated with comparable efficacy to clopidogrel in reducing the risk of ischemic stroke in a recent phase III study.The authors provide an overview of the potential role of prasugrel in the ...
Udaya S, Tantry +4 more
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Prasugrel hydrochloride, dronedarone, and saxagliptin hydrochloride
Journal of the American Pharmacists Association, 2009Antiplatelet agent Acute coronary syndrome (ACS), which includes unstable angina and myocardial infarction (MI), affects approximately 1.5 million Americans each year. Many of these individuals are candidates for percutaneous coronary intervention (PCI; angioplasty), a procedure in which a balloon device is used to open coronary arteries that are ...
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Acquired Factor V Inhibitor with Hemorrhagic Symptoms after Prasugrel Hydrochloride Treatment
Acta Haematologica, 2019Acquired factor V inhibitor (AFVI) is a rare coagulopathy. It may be triggered by specific antigens such as antibiotics. We herein report the first case of AFVI after treatment with prasugrel hydrochloride (prasugrel) in an 80-year-old male who underwent percutaneous coronary intervention because of angina pectoris 6 years ago and was initiated on ...
Kazuki, Sakatoku +5 more
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INDIAN DRUGS, 2014
The objective of this study was to investigate nanosuspensions, hydroxypropyl-β-cyclodextrin (HPβCD) complexes and SLS powders for enhancing the solubility and dissolution rate of Prasugrel HCl (PHCl) so as to reduce the fluctuations in its oral bioavailability. PHCl nanosuspensions were prepared using evaporative precipitation method.
R. K Devara +5 more
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The objective of this study was to investigate nanosuspensions, hydroxypropyl-β-cyclodextrin (HPβCD) complexes and SLS powders for enhancing the solubility and dissolution rate of Prasugrel HCl (PHCl) so as to reduce the fluctuations in its oral bioavailability. PHCl nanosuspensions were prepared using evaporative precipitation method.
R. K Devara +5 more
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Solution-Mediated Polymorphic Transformation of Prasugrel Hydrochloride from Form II to Form I
Industrial & Engineering Chemistry Research, 2014In situ Raman spectroscopy was applied for the analysis of the solution-mediated polymorphic transformation of prasugrel hydrochloride from the metastable form II to the stable form I. The solution concentration during the transition process was monitored by a gravimetric method.
Wei Du +8 more
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Pharmaceutics and Pharmacology Research, 2022
The objective of this study was to investigate nanosuspensions for enhancing the solubility and dissolution rate of Prasugrel HCl (PHCl) so as to reduce the fluctuations in its oral bioavailability. Prasugrel Hydrochloride nanosuspensions were prepared using evaporative precipitation method. After preparation, various nanosuspensions were characterized
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The objective of this study was to investigate nanosuspensions for enhancing the solubility and dissolution rate of Prasugrel HCl (PHCl) so as to reduce the fluctuations in its oral bioavailability. Prasugrel Hydrochloride nanosuspensions were prepared using evaporative precipitation method. After preparation, various nanosuspensions were characterized
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Blood, 2005
Abstract The thienopyridine antiplatelet prodrug clopidogrel bisulfate (C) is widely used for atherothrombotic diseases. However, several reports have described a limitation of C, namely, poor platelet inhibition in many patients following oral dosing.
Yoichi Niitsu +7 more
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Abstract The thienopyridine antiplatelet prodrug clopidogrel bisulfate (C) is widely used for atherothrombotic diseases. However, several reports have described a limitation of C, namely, poor platelet inhibition in many patients following oral dosing.
Yoichi Niitsu +7 more
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Asian Journal of Research in Chemistry, 2016
Three simple and sensitive extractive spectrophotometric methods have been described for the assay of ondansetron hydrochloride either in pure form or in pharmaceutical formulations. The developed methods involve formation of coloured chloroform extractable ion-pair complexes of the drug with bromothymol blue (BTB), bromophenol blue (BPB) and ...
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Three simple and sensitive extractive spectrophotometric methods have been described for the assay of ondansetron hydrochloride either in pure form or in pharmaceutical formulations. The developed methods involve formation of coloured chloroform extractable ion-pair complexes of the drug with bromothymol blue (BTB), bromophenol blue (BPB) and ...
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Asian Journal of Research in Chemistry
The present work reports rapid, sensitive and specific methods for determination of Prasugrel and its impurities by gas chromatography with mass spectrometry and high-performance liquid chromatography. The proposed method presented excellent intraday precision (% RSD < 1), and accuracy 99.23 to 100.40% and 99.48 to 100.81% for Prasugrel and 2-bromo ...
Manohar Reddy Epuru +3 more
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The present work reports rapid, sensitive and specific methods for determination of Prasugrel and its impurities by gas chromatography with mass spectrometry and high-performance liquid chromatography. The proposed method presented excellent intraday precision (% RSD < 1), and accuracy 99.23 to 100.40% and 99.48 to 100.81% for Prasugrel and 2-bromo ...
Manohar Reddy Epuru +3 more
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International Journal of Drug Delivery Technology
Prasugrel hydrochloride (Prasugrel HCl), a potent thienopyridine-class antiplatelet agent, is classified as a Biopharmaceutics Classification System (BCS) Class II drug, characterized by low aqueous solubility and high permeability, which limits its oral bioavailability.
Suryawanshi A.N., Ratnaparkhi M.P.
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Prasugrel hydrochloride (Prasugrel HCl), a potent thienopyridine-class antiplatelet agent, is classified as a Biopharmaceutics Classification System (BCS) Class II drug, characterized by low aqueous solubility and high permeability, which limits its oral bioavailability.
Suryawanshi A.N., Ratnaparkhi M.P.
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