Results 131 to 140 of about 1,084 (158)
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Journal of Pharmaceutical and Biomedical Analysis, 2015
A fast and selective capillary electrophoresis method was developed and validated for the simultaneous determination of the hydrochloride and acetic acid content in prasugrel hydrochloride. Because of the poor chromophore, the indirect detection was chosen.
Wioleta Maruszak, Marcin Cybulski
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A fast and selective capillary electrophoresis method was developed and validated for the simultaneous determination of the hydrochloride and acetic acid content in prasugrel hydrochloride. Because of the poor chromophore, the indirect detection was chosen.
Wioleta Maruszak, Marcin Cybulski
exaly +3 more sources
Effects of Solvent on Polymorph Formation and Nucleation of Prasugrel Hydrochloride
Crystal Growth and Design, 2014Three intrinsic properties of solvent were used to evaluate the effects of solvent on polymorph formation of prasugrel hydrochloride. In situ Raman spectroscopy, FTIR, and powder X-ray diffraction were used to characterize two solvent-free polymorphs and five solvates of prasugrel hydrochloride, the two of which were reported for the first time ...
Wei Du, Qiuxiang Yin, Junbo Gong
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Process Improvements of Prasugrel Hydrochloride: An Adenosine Diphosphate Receptor Antagonist
Organic Process Research and Development, 2012An improved process for the synthesis of prasugrel hydrochloride with an overall yield of 58%, 99.9% purity, and meeting all other quality requirements is described.
Sampath Aalla +5 more
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Journal of Liquid Chromatography and Related Technologies, 2012
A simple, sensitive, and reproducible gradient reverse-phase ultra-performance liquid chromatographic (UPLC) method was developed for the quantitative determination of Prasugrel and all possible process-related impurities (positional isomers, degradants and byproducts) at the level of 0.5–2.0 µg mL−1.
M V Suryanarayana
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A simple, sensitive, and reproducible gradient reverse-phase ultra-performance liquid chromatographic (UPLC) method was developed for the quantitative determination of Prasugrel and all possible process-related impurities (positional isomers, degradants and byproducts) at the level of 0.5–2.0 µg mL−1.
M V Suryanarayana
exaly +2 more sources
Journal of Separation Science, 2015
Prasugrel was subjected to forced degradation studies under conditions of hydrolysis (acid, base, and neutral), photolysis, oxidation, and thermal stress. The drug showed liability in hydrolytic as well as oxidative conditions, resulting in a total of four degradation products.
Dilip Kumar Singh +2 more
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Prasugrel was subjected to forced degradation studies under conditions of hydrolysis (acid, base, and neutral), photolysis, oxidation, and thermal stress. The drug showed liability in hydrolytic as well as oxidative conditions, resulting in a total of four degradation products.
Dilip Kumar Singh +2 more
exaly +3 more sources
An overview of the utility of prasugrel hydrochloride as a treatment option for ischemic stroke
Expert Review of Neurotherapeutics, 2023Prasugrel, a potent P2Y12 receptor inhibitor, is not currently recommended in patients with stroke due to a higher rate of recurrent stroke. Prasugrel was associated with comparable efficacy to clopidogrel in reducing the risk of ischemic stroke in a recent phase III study.The authors provide an overview of the potential role of prasugrel in the ...
Udaya S, Tantry +4 more
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Prasugrel hydrochloride for the treatment of sickle cell disease
Expert Opinion on Investigational Drugs, 2017Therapeutic options for sickle cell disease (SCD) are limited and, currently, only one drug (hydroxyurea) has FDA approval for the treatment of adult SCD. While this genetic disease is caused by hemoglobin polymerization, subsequent downstream events trigger platelet activation, vaso-occlusion and the disease's complex pathophysiology.
Conran, Nicola, Rees, David C
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Prasugrel hydrochloride for the treatment of acute coronary syndromes
Expert Opinion on Pharmacotherapy, 2015P2Y12 receptor antagonists, by inhibiting platelet activation and subsequent aggregation, are critical to prevent ischemic event recurrence after an acute coronary syndrome (ACS). Prasugrel is a third-generation thienopyridine whose metabolites target the P2Y12 receptor.
Thibault, Lhermusier, Ron, Waksman
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Prasugrel hydrochloride, dronedarone, and saxagliptin hydrochloride
Journal of the American Pharmacists Association, 2009Antiplatelet agent Acute coronary syndrome (ACS), which includes unstable angina and myocardial infarction (MI), affects approximately 1.5 million Americans each year. Many of these individuals are candidates for percutaneous coronary intervention (PCI; angioplasty), a procedure in which a balloon device is used to open coronary arteries that are ...
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Acquired Factor V Inhibitor with Hemorrhagic Symptoms after Prasugrel Hydrochloride Treatment
Acta Haematologica, 2019Acquired factor V inhibitor (AFVI) is a rare coagulopathy. It may be triggered by specific antigens such as antibiotics. We herein report the first case of AFVI after treatment with prasugrel hydrochloride (prasugrel) in an 80-year-old male who underwent percutaneous coronary intervention because of angina pectoris 6 years ago and was initiated on ...
Kazuki, Sakatoku +5 more
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