Requirement for highly efficient pre-mRNA splicing during Drosophila early embryonic development [PDF]
eLife, 2014 Drosophila syncytial nuclear divisions limit transcription unit size of early zygotic genes. As mitosis inhibits not only transcription, but also pre-mRNA splicing, we reasoned that constraints on splicing were likely to exist in the early embryo, being ...
Leonardo Gastón Guilgur +5 more
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Genome Biology, 2018 Understanding the functional impact of genomic variants is a major goal of modern genetics and personalized medicine. Although many synonymous and non-coding variants act through altering the efficiency of pre-mRNA splicing, it is difficult to predict ...
Scott I. Adamson +2 more
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SR proteins: a conserved family of pre-mRNA splicing factors. [PDF]
Genes & Development, 1992 We demonstrate that four different proteins from calf thymus are able to restore splicing in the same splicing-deficient extract using several different pre-mRNA substrates.
Alan M. Zahler +3 more
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Regulation of Pre-mRNA Splicing: Indispensable Role of Post-Translational Modifications of Splicing Factors [PDF]
Life, 2023 Pre-mRNA splicing is a process used by eukaryotic cells to generate messenger RNAs that can be translated into proteins. During splicing, the non-coding regions of the RNAs (introns) are removed from pre-mRNAs and the coding regions (exons) are joined ...
Miroslava Kretova +3 more
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RBM5 is a male germ cell splicing factor and is required for spermatid differentiation and male fertility. [PDF]
PLoS Genetics, 2013 Alternative splicing of precursor messenger RNA (pre-mRNA) is common in mammalian cells and enables the production of multiple gene products from a single gene, thus increasing transcriptome and proteome diversity.
Moira K O'Bryan +11 more
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Prediction of alternative pre-mRNA splicing outcomes [PDF]
Scientific Reports, 2023 To understand the biological impact of alternative pre-mRNA splicing, it is vital to know which exons are involved, what protein domains they encode, and how the translated isoforms differ.
Rayan Najjar, Tomas Mustelin
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Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor [PDF]
eLifeDysregulated pre-mRNA splicing and metabolism are two hallmarks of MYC-driven cancers. Pharmacological inhibition of both processes has been extensively investigated as potential therapeutic avenues in preclinical and clinical studies.
Carolyn M Jablonowski +20 more
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Differential recruitment of pre-mRNA splicing factors to alternatively spliced transcripts in vivo. [PDF]
PLoS Biology, 2005 Alternative splicing in mammalian cells has been suggested to be largely controlled by combinatorial binding of basal splicing factors to pre-mRNA templates.
Stephen A Mabon, Tom Misteli
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Splicing-Mediated Autoregulation Modulates Rpl22p Expression in Saccharomyces cerevisiae. [PDF]
PLoS Genetics, 2016 In Saccharomyces cerevisiae, splicing is critical for expression of ribosomal protein genes (RPGs), which are among the most highly expressed genes and are tightly regulated according to growth and environmental conditions.
Jason Gabunilas, Guillaume Chanfreau
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Regulation of RNA Splicing: Aberrant Splicing Regulation and Therapeutic Targets in Cancer
Cells, 2021 RNA splicing is a critical step in the maturation of precursor mRNA (pre-mRNA) by removing introns and exons. The combination of inclusion and exclusion of introns and exons in pre-mRNA can generate vast diversity in mature mRNA from a limited number of ...
Koji Kitamura, Keisuke Nimura
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