Requirement for highly efficient pre-mRNA splicing during Drosophila early embryonic development [PDF]
eLife, 2014 Drosophila syncytial nuclear divisions limit transcription unit size of early zygotic genes. As mitosis inhibits not only transcription, but also pre-mRNA splicing, we reasoned that constraints on splicing were likely to exist in the early embryo, being ...
Leonardo Gastón Guilgur +5 more
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RBM5 is a male germ cell splicing factor and is required for spermatid differentiation and male fertility. [PDF]
PLoS Genetics, 2013 Alternative splicing of precursor messenger RNA (pre-mRNA) is common in mammalian cells and enables the production of multiple gene products from a single gene, thus increasing transcriptome and proteome diversity.
Moira K O'Bryan +11 more
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Abnormal splicing of ABCA1 pre-mRNA in Tangier disease due to a IVS2 +5G>C mutation in ABCA1 gene [PDF]
Journal of Lipid Research, 2003 Two point mutations of ABCA1 gene were found in a patient with Tangier disease (TD): i) G>C in intron 2 (IVS2 +5G>C) and ii) c.844 C>T in exon 9 (R282X).
Serena Altilia +12 more
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Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor [PDF]
eLifeDysregulated pre-mRNA splicing and metabolism are two hallmarks of MYC-driven cancers. Pharmacological inhibition of both processes has been extensively investigated as potential therapeutic avenues in preclinical and clinical studies.
Carolyn M Jablonowski +20 more
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Pre-mRNA splicing modulates post-harvest deterioration of cassava storage root. [PDF]
Plant PhysiolKu YS.
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Differential recruitment of pre-mRNA splicing factors to alternatively spliced transcripts in vivo. [PDF]
PLoS Biology, 2005 Alternative splicing in mammalian cells has been suggested to be largely controlled by combinatorial binding of basal splicing factors to pre-mRNA templates.
Stephen A Mabon, Tom Misteli
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Splicing-Mediated Autoregulation Modulates Rpl22p Expression in Saccharomyces cerevisiae. [PDF]
PLoS Genetics, 2016 In Saccharomyces cerevisiae, splicing is critical for expression of ribosomal protein genes (RPGs), which are among the most highly expressed genes and are tightly regulated according to growth and environmental conditions.
Jason Gabunilas, Guillaume Chanfreau
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Life, 2023 Pre-mRNA splicing is a process used by eukaryotic cells to generate messenger RNAs that can be translated into proteins. During splicing, the non-coding regions of the RNAs (introns) are removed from pre-mRNAs and the coding regions (exons) are joined ...
Miroslava Kretova +3 more
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Rational Design of an Activatable Reporter for Quantitative Imaging of RNA Aberrant Splicing In Vivo
Molecular Therapy: Methods & Clinical Development, 2020 Pre-mRNA splicing, the process of removing introns from pre-mRNA and the arrangement of exons to produce mature transcripts, is a crucial step in the expression of most eukaryote genes. However, the splicing kinetics remain poorly characterized in living
Jinrong Xie +5 more
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Regulation of RNA Splicing: Aberrant Splicing Regulation and Therapeutic Targets in Cancer
Cells, 2021 RNA splicing is a critical step in the maturation of precursor mRNA (pre-mRNA) by removing introns and exons. The combination of inclusion and exclusion of introns and exons in pre-mRNA can generate vast diversity in mature mRNA from a limited number of ...
Koji Kitamura, Keisuke Nimura
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