Results 1 to 10 of about 203,728 (290)
RBM5 is a male germ cell splicing factor and is required for spermatid differentiation and male fertility. [PDF]
PLoS Genetics, 2013 Alternative splicing of precursor messenger RNA (pre-mRNA) is common in mammalian cells and enables the production of multiple gene products from a single gene, thus increasing transcriptome and proteome diversity.
Moira K O'Bryan +11 more
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Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor [PDF]
eLifeDysregulated pre-mRNA splicing and metabolism are two hallmarks of MYC-driven cancers. Pharmacological inhibition of both processes has been extensively investigated as potential therapeutic avenues in preclinical and clinical studies.
Carolyn M Jablonowski +20 more
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Differential recruitment of pre-mRNA splicing factors to alternatively spliced transcripts in vivo. [PDF]
PLoS Biology, 2005 Alternative splicing in mammalian cells has been suggested to be largely controlled by combinatorial binding of basal splicing factors to pre-mRNA templates.
Stephen A Mabon, Tom Misteli
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Splicing-Mediated Autoregulation Modulates Rpl22p Expression in Saccharomyces cerevisiae. [PDF]
PLoS Genetics, 2016 In Saccharomyces cerevisiae, splicing is critical for expression of ribosomal protein genes (RPGs), which are among the most highly expressed genes and are tightly regulated according to growth and environmental conditions.
Jason Gabunilas, Guillaume Chanfreau
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Life, 2023 Pre-mRNA splicing is a process used by eukaryotic cells to generate messenger RNAs that can be translated into proteins. During splicing, the non-coding regions of the RNAs (introns) are removed from pre-mRNAs and the coding regions (exons) are joined ...
Miroslava Kretova +3 more
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Molecular Therapy: Methods & Clinical Development, 2020 Pre-mRNA splicing, the process of removing introns from pre-mRNA and the arrangement of exons to produce mature transcripts, is a crucial step in the expression of most eukaryote genes. However, the splicing kinetics remain poorly characterized in living
Jinrong Xie +5 more
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Inflammation-Induced Alternative Pre-mRNA Splicing in Mouse Alveolar Macrophages
G3: Genes, Genomes, Genetics, 2020 Alveolar macrophages serve as central orchestrators of inflammatory responses in the lungs, both initiating their onset and promoting their resolution. However, the mechanisms that program macrophages for these dynamic responses are not fully understood.
William J. Janssen +8 more
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Regulation of RNA Splicing: Aberrant Splicing Regulation and Therapeutic Targets in Cancer
Cells, 2021 RNA splicing is a critical step in the maturation of precursor mRNA (pre-mRNA) by removing introns and exons. The combination of inclusion and exclusion of introns and exons in pre-mRNA can generate vast diversity in mature mRNA from a limited number of ...
Koji Kitamura, Keisuke Nimura
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Pre-mRNA secondary structures influence exon recognition. [PDF]
PLoS Genetics, 2007 The secondary structure of a pre-mRNA influences a number of processing steps including alternative splicing. Since most splicing regulatory proteins bind to single-stranded RNA, the sequestration of RNA into double strands could prevent their binding ...
Michael Hiller +3 more
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RNA catalyses nuclear pre-mRNA splicing [PDF]
Nature, 2013 In nuclear pre-messenger RNA splicing, introns are excised by the spliceosome, a dynamic machine composed of both proteins and small nuclear RNAs (snRNAs). Over thirty years ago, after the discovery of self-splicing group II intron RNAs, the snRNAs were proposed to catalyse splicing.
Fica, Sebastian M. +8 more
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