Results 51 to 60 of about 211,616 (238)
General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer [PDF]
, 1993 The general splicing factor SF2/ASF binds in a sequence-specific manner to a purine-rich exonic splicing enhancer (ESE) in the last exon of bovine growth hormone (bGH) pre-mRNA.
Hampson, R. K. +4 more
core +1 more source
Regulation of gonadotropin receptor gene expression [PDF]
, 1994 The receptors for the gonadotropins differ from the other G protein-coupled receptors by having a large extracellular hormone-binding domain, encoded by nine or ten exons.
Grootegoed, J.A. (Anton) +2 more
core +1 more source
Principles and correction of 5’-splice site selection
RNA Biology, 2022 In Eukarya, immature mRNA transcripts (pre-mRNA) often contain coding sequences, or exons, interleaved by non-coding sequences, or introns. Introns are removed upon splicing, and further regulation of the retained exons leads to alternatively spliced ...
Florian Malard +2 more
doaj +1 more source
Identification of Nuclear and Cytoplasmic mRNA Targets for the Shuttling Protein SF2/ASF [PDF]
, 2008 The serine and arginine-rich protein family (SR proteins) are highly conserved regulators of pre-mRNA splicing. SF2/ASF, a prototype member of the SR protein family, is a multifunctional RNA binding protein with roles in pre-mRNA splicing, mRNA export ...
Caceres, Javier F +5 more
core +6 more sources
The Supraspliceosome — A Multi-Task Machine for Regulated Pre-mRNA Processing in the Cell Nucleus
Computational and Structural Biotechnology Journal, 2014 Pre-mRNA splicing of Pol II transcripts is executed in the mammalian cell nucleus within a huge (21 MDa) and highly dynamic RNP machine — the supraspliceosome.
Kinneret Shefer +2 more
doaj +1 more source
Identification of an Alternative Exon in a GABA Receptor Gene [PDF]
, 2018 The central dogma of biology states that DNA is transcribed into mRNA, which is then translated into proteins. In order for translation to occur, pre-mRNAs first must be processed.
Apgar, Shannon, Toro, Cecilia P.
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Pre‐mRNA splicing modulations in senescence [PDF]
Aging Cell, 2002 SummaryAging and associated diseases involve multilevel changes in the complex phenomenon of alternative splicing. Here, we review the potential genomic and environmental origins of such changes and discuss the research implications of these findings.
Eran, Meshorer, Hermona, Soreq
openaire +2 more sources
CRH-R splicing in estrogen-sensitive breast cancer [PDF]
, 2014 Alternative pre-mRNA splicing contributes in the acquired genomic alterations involved in the pathobiology of cancer development and progression.1 In normal biological systems, this mechanism allows protein complexity and diversity by increasing gene ...
Grammatopoulos, Dimitris
core +1 more source
CDK11 Complexes Promote Pre-mRNA Splicing [PDF]
Journal of Biological Chemistry, 2003 The PITSLRE protein kinases, hereafter referred to as CDK11 because of their association with the cyclin L regulatory partner, belong to large molecular weight protein complexes that contain RNA polymerase II. These CDK11(p110) complexes have been reported to influence transcription as well as interact with the general pre-mRNA-splicing factor RNPS1 ...
Dongli, Hu +4 more
openaire +2 more sources
Development of an in vitro pre-mRNA splicing assay using plant nuclear extract
Plant Methods, 2018 Background Pre-mRNA splicing is an essential post-transcriptional process in all eukaryotes. In vitro splicing systems using nuclear or cytoplasmic extracts from mammalian cells, yeast, and Drosophila have provided a wealth of mechanistic insights into ...
Mohammed Albaqami, Anireddy S. N. Reddy
doaj +1 more source