Unexpected role of the steroid-deficiency protein ecdysoneless in pre-mRNA splicing. [PDF]
PLoS Genetics, 2014 The steroid hormone ecdysone coordinates insect growth and development, directing the major postembryonic transition of forms, metamorphosis. The steroid-deficient ecdysoneless1 (ecd1) strain of Drosophila melanogaster has long served to assess the ...
Ann-Katrin Claudius +4 more
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A unified mechanism for intron and exon definition and back-splicing. [PDF]
, 2019 The molecular mechanisms of exon definition and back-splicing are fundamental unanswered questions in pre-mRNA splicing. Here we report cryo-electron microscopy structures of the yeast spliceosomal E complex assembled on introns, providing a view of the ...
Cui, Yanxiang +12 more
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Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing [PDF]
, 2002 To examine the involvement of interchromatin granule clusters (IGCs) in transcription and pre-mRNA splicing in mammalian cell nuclei, the serine-arginine (SR) protein kinase cdc2-like kinase (Clk)/STY was used as a tool to manipulate IGC integrity in ...
Sacco-Bubulya, P. A., Spector, D. L.
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Molecular Genetics & Genomic Medicine, 2023 Background Gitelman syndrome (GS) is a type of salt‐losing tubular disease, most of which is caused by SLC12A3 gene variants, and missense variants account for the majority.
Xiaomeng Shi +10 more
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Splicing-coupled 3' end formation requires a terminal splice acceptor site, but not intron excision [PDF]
, 2012 Splicing of human pre-mRNA is reciprocally coupled to 3′ end formation by terminal exon definition, which occurs co-transcriptionally. It is required for the final maturation of most human pre-mRNAs and is therefore important to understand.
Davidson, L., West, S.
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α-Globin pre-mRNA splicing, revisited [PDF]
Blood, 2019 In this issue of Blood, Ji et al have identified a novel regulatory mechanism that ensures proper splicing of human α-globin pre-messenger RNA (pre-mRNA).
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The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages
Cell Reports, 2019 Summary: While transcriptional control of innate immune gene expression is well characterized, almost nothing is known about how pre-mRNA splicing decisions influence, or are influenced by, macrophage activation.
Kelsi O. West +5 more
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Towards an analysis of in vitro RNA binding capabilities of essential splicing factor U2AF [PDF]
, 2011 U2 auxiliary factor (U2AF) is an important component of the eukaryotic spliceosome and is essential for pre-mRNA splicing in Schizosaccharomyces pombe. Studies have shown that RNA binding is required for U2AF’s role in spliceosome assembly. We have found
Christy, Alexis
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Targeting a Pre-mRNA Structure with Bipartite Antisense Molecules Modulates Tau Alternative Splicing [PDF]
, 2012 Approximately 15% of human genetic diseases are estimated to involve dysregulation of alternative pre-mRNA splicing. Antisense molecules designed to alter these and other splicing events typically target continuous linear sequences of the message.
Liu, Yang +3 more
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A coactivator of pre-mRNA splicing [PDF]
Genes & Development, 1998 The nuclear matrix antigen recognized by the monoclonal antibody (mAb) B1C8 is a novel serine (S) and arginine (R)-rich protein associated with splicing complexes and is named here SRm160 (SR-related matrix protein of 160 kD). SRm160 contains multiple SR repeats, but unlike proteins of the SR family of splicing factors, lacks an RNA recognition motif ...
B J, Blencowe +3 more
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